KEGG   ORTHOLOGY: K13240
Entry
K13240                      KO                                     

Name
NOS1
Definition
nitric-oxide synthase, brain [EC:1.14.13.39]
Pathway
ko00220  Arginine biosynthesis
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04020  Calcium signaling pathway
ko04145  Phagosome
ko04371  Apelin signaling pathway
ko04713  Circadian entrainment
ko04730  Long-term depression
ko04926  Relaxin signaling pathway
ko04970  Salivary secretion
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis (ALS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13240  NOS1; nitric-oxide synthase, brain
   00330 Arginine and proline metabolism
    K13240  NOS1; nitric-oxide synthase, brain
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
   04020 Calcium signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K13240  NOS1; nitric-oxide synthase, brain
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
  09154 Digestive system
   04970 Salivary secretion
    K13240  NOS1; nitric-oxide synthase, brain
  09156 Nervous system
   04730 Long-term depression
    K13240  NOS1; nitric-oxide synthase, brain
  09159 Environmental adaptation
   04713 Circadian entrainment
    K13240  NOS1; nitric-oxide synthase, brain
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K13240  NOS1; nitric-oxide synthase, brain
   05014 Amyotrophic lateral sclerosis (ALS)
    K13240  NOS1; nitric-oxide synthase, brain
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13240  NOS1; nitric-oxide synthase, brain
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
HSA: 4842(NOS1)
PTR: 467139(NOS1)
PPS: 100996089(NOS1)
GGO: 101147071(NOS1)
PON: 100433069(NOS1)
NLE: 100597250(NOS1)
MCC: 693781(NOS1)
MCF: 102123521(NOS1)
RRO: 104675533(NOS1)
RBB: 108539288(NOS1)
CJC: 100895717(NOS1)
SBQ: 101034544(NOS1)
MMU: 18125(Nos1)
MCAL: 110294416(Nos1)
MPAH: 110312876(Nos1)
RNO: 24598(Nos1)
MUN: 110551884(Nos1)
CGE: 100758127(Nos1)
NGI: 103745523(Nos1)
HGL: 101711993(Nos1)
CCAN: 109686387(Nos1)
OCU: 100009243(NOS1)
TUP: 102480558(NOS1)
CFA: 477498(NOS1)
VVP: 112932933(NOS1)
AML: 100468087(NOS1)
UMR: 103661304(NOS1)
UAH: 113266817(NOS1)
ORO: 101375441(NOS1)
ELK: 111156411
FCA: 101100342(NOS1)
PTG: 102962715(NOS1)
PPAD: 109277571(NOS1)
AJU: 106971710(NOS1)
BTA: 536132(NOS1)
BOM: 102280537(NOS1)
BIU: 109571319(NOS1)
BBUB: 102400136(NOS1)
CHX: 102185490(NOS1)
OAS: 443533(NOS1)
SSC: 100520934(NOS1)
CFR: 102508946(NOS1)
CDK: 105104911(NOS1)
BACU: 103008209(NOS1)
LVE: 103090138(NOS1)
OOR: 101273057(NOS1)
DLE: 111186931(NOS1)
PCAD: 102991967(NOS1)
ECB: 100051079(NOS1)
EPZ: 103547950(NOS1)
EAI: 106839766(NOS1)
MYB: 102260489(NOS1)
MYD: 102763635(NOS1)
MNA: 107528483(NOS1)
HAI: 109382238(NOS1)
DRO: 112310614(NOS1)
PALE: 102884569(NOS1)
RAY: 107513162(NOS1)
MJV: 108397443(NOS1)
LAV: 100673992(NOS1)
TMU: 101342004
MDO: 100013712(NOS1)
SHR: 100921140(NOS1)
PCW: 110222812(NOS1)
OAA: 100093259(NOS1)
GGA: 427721(NOS1)
MGP: 100538441(NOS1)
CJO: 107321466(NOS1)
NMEL: 110406170(NOS1)
APLA: 101798766(NOS1)
ACYG: 106045554(NOS1)
TGU: 100231414(NOS1) 116807264
LSR: 110474155(NOS1)
SCAN: 103818226(NOS1)
GFR: 102042821(NOS1)
FAB: 101820761(NOS1)
PHI: 102106809(NOS1)
PMAJ: 107211573(NOS1)
CCAE: 111936662(NOS1)
CCW: 104695038(NOS1)
ETL: 114071586(NOS1)
FPG: 101916747(NOS1)
FCH: 102047821(NOS1)
CLV: 102093432(NOS1)
EGZ: 104129871(NOS1)
NNI: 104010553(NOS1)
ACUN: 113486129(NOS1)
PADL: 103913684(NOS1)
AAM: 106493898(NOS1)
ASN: 102380334(NOS1)
AMJ: 102561243(NOS1)
PSS: 102444149(NOS1)
CMY: 102941829(NOS1)
CPIC: 101937660(NOS1)
ACS: 100562233(nos1)
PVT: 110090104(NOS1)
PBI: 103052972(NOS1)
PMUR: 107295430(NOS1)
PMUA: 114587067(NOS1)
GJA: 107112296(NOS1)
XLA: 108707179(nos1.S) 373705(nos1.L)
XTR: 100497595(nos1)
NPR: 108785232(NOS1)
DRE: 60658(nos1)
SRX: 107726721 107755829(nos1)
SANH: 107668720 107704495(nos1)
SGH: 107599142(nos1) 107599638
IPU: 108255344(nos1)
PHYP: 113537215(nos1)
AMEX: 103046065(nos1)
EEE: 113577767(nos1)
TRU: 101066909(nos1)
LCO: 104923687(nos1)
NCC: 104967506(nos1)
MZE: 101485683(nos1)
ONL: 100534582(nos1)
OLA: 100049502(nos1)
XMA: 102233853(nos1)
XCO: 114154866(nos1)
PRET: 103469871(nos1)
CVG: 107087335(nos1)
NFU: 107386248(nos1)
KMR: 108246938(nos1)
ALIM: 106519449(nos1)
AOCE: 111572539(nos1)
CSEM: 103396877 103397851(nos1)
POV: 109637139(nos1)
LCF: 108903114(nos1)
SDU: 111227324(nos1)
SLAL: 111663111(nos1)
HCQ: 109525272(nos1)
BPEC: 110155016(nos1)
MALB: 109959109(nos1)
SASA: 100136388(nos1) 106585241
ELS: 105031277(nos1)
SFM: 108927312(nos1)
PKI: 111851114 111852748(nos1)
LCM: 102348281(NOS1)
CMK: 103184386(nos1)
RTP: 109914181(nos1) 109922224
CIN: 100183039
DME: Dmel_CG6713(Nos)
DER: 6542987
DSE: 6612066
DSI: Dsimw501_GD22223(Dsim_GD22223)
DAN: 6496893
DSR: 110183462
DPE: 6596585
DMN: 108163699
DWI: 6641760
DAZ: 108609612
DNV: 108658145
DHE: 111601524
DVI: 6629111
MDE: 101891936
LCQ: 111681704
AAG: 5572370
AME: 503861(NOS)
BIM: 100749227
BTER: 100650517
CCAL: 108625325
OBB: 114871710
SOC: 105200228
MPHA: 105829748
AEC: 105149468
ACEP: 105625167
PBAR: 105432905
VEM: 105557978
HST: 105183230
DQU: 106744004
CFO: 105250272
LHU: 105675559
PGC: 109856190
OBO: 105286125
PCF: 106793080
NVI: 100313941(Nos)
CSOL: 105360744
MDL: 103570884
TCA: 655549
DPA: 109546644
NVL: 108558954
BMOR: 100144542(NOS2) 692510(NOS1)
API: 100160390
DNX: 107172687
AGS: 114128082
RMD: 113551041
BTAB: 109031807
CLEC: 106661589
ZNE: 110828058
FCD: 110850636
TUT: 107370056
DPTE: 113792010
PTEP: 107440636
PCAN: 112563084
CRG: 105322950
MYI: 110460719
LAK: 106169208
NVE: 5511062
EPA: 110253339
PDAM: 113685754
HMG: 101240122
 » show all
Reference
PMID:7528745
  Authors
Hall AV, Antoniou H, Wang Y, Cheung AH, Arbus AM, Olson SL, Lu WC, Kau CL, Marsden PA
  Title
Structural organization of the human neuronal nitric oxide synthase gene (NOS1).
  Journal
J Biol Chem 269:33082-90 (1994)
  Sequence
[hsa:4842]

KEGG   ORTHOLOGY: K13241
Entry
K13241                      KO                                     

Name
NOS2
Definition
nitric-oxide synthase, inducible [EC:1.14.13.39]
Pathway
ko00220  Arginine biosynthesis
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04146  Peroxisome
ko04371  Apelin signaling pathway
ko04926  Relaxin signaling pathway
ko05010  Alzheimer disease
ko05133  Pertussis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00017  Esophageal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13241  NOS2; nitric-oxide synthase, inducible
   00330 Arginine and proline metabolism
    K13241  NOS2; nitric-oxide synthase, inducible
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04066 HIF-1 signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04020 Calcium signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K13241  NOS2; nitric-oxide synthase, inducible
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K13241  NOS2; nitric-oxide synthase, inducible
  09171 Infectious disease: bacterial
   05133 Pertussis
    K13241  NOS2; nitric-oxide synthase, inducible
   05152 Tuberculosis
    K13241  NOS2; nitric-oxide synthase, inducible
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05145 Toxoplasmosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05140 Leishmaniasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05142 Chagas disease (American trypanosomiasis)
    K13241  NOS2; nitric-oxide synthase, inducible
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13241  NOS2; nitric-oxide synthase, inducible
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
HSA: 4843(NOS2)
PTR: 455026(NOS2)
PPS: 100976546(NOS2)
GGO: 101134923(NOS2)
PON: 100436584(NOS2)
NLE: 100589003(NOS2)
MCC: 114673005 706921(NOS2)
MCF: 102121432(NOS2)
CSAB: 103242598 103242600(NOS2)
RRO: 104669357(NOS2)
RBB: 108539959(NOS2)
CJC: 100403192(NOS2)
SBQ: 101041016(NOS2)
MMU: 18126(Nos2)
MCAL: 110304621(Nos2)
MPAH: 110331408(Nos2)
RNO: 24599(Nos2) 497963
MUN: 110550157(Nos2)
CGE: 100760062(Nos2)
NGI: 103724501(Nos2)
HGL: 101699617(Nos2)
CCAN: 109693015(Nos2)
OCU: 100008833(NOS2)
TUP: 102471872(NOS2)
CFA: 403822(NOS2)
VVP: 112933146(NOS2)
AML: 100470060(NOS2)
UMR: 103667420(NOS2)
UAH: 113269018(NOS2)
ORO: 101380967(NOS2)
ELK: 111151537
FCA: 101087020(NOS2)
PTG: 102950049(NOS2)
PPAD: 109251875(NOS2)
AJU: 106984382(NOS2)
BTA: 282876(NOS2)
BOM: 102265893(NOS2)
BIU: 109574459(NOS2)
BBUB: 102401026(NOS2)
CHX: 100860742(NOS2)
OAS: 443078(NOS2)
SSC: 396859(NOS2)
CFR: 102518523(NOS2)
CDK: 105088198(NOS2)
BACU: 103003780(NOS2)
LVE: 103074308(NOS2)
OOR: 101280638(NOS2)
DLE: 111185989
PCAD: 102990905(NOS2)
ECB: 791246(NOS2)
EPZ: 103567002
EAI: 106844596(NOS2)
MYB: 102253125(NOS2)
MYD: 102768087(NOS2)
MNA: 107533063(NOS2)
HAI: 109385084(NOS2)
DRO: 112308600(NOS2)
PALE: 102878456(NOS2)
RAY: 107497410(NOS2)
MJV: 108397044(NOS2)
LAV: 100676634(NOS2)
TMU: 101356579
MDO: 100024271(NOS2)
SHR: 100927789(NOS2)
PCW: 110192171(NOS2)
OAA: 100075386(NOS2)
GGA: 395807(NOS2)
MGP: 692136(NOS2)
CJO: 107322733(NOS2)
NMEL: 110407551(NOS2)
APLA: 101804455(NOS2)
ACYG: 106043795(NOS2)
TGU: 100230954(NOS2)
LSR: 110471958(NOS2)
SCAN: 103820198(NOS2)
GFR: 102044468(NOS2)
FAB: 101817488(NOS2)
PHI: 102108817(NOS2)
PMAJ: 107212812(NOS2)
CCAE: 111937881(NOS2)
CCW: 104690967(NOS2)
ETL: 114057504(NOS2)
FPG: 101921726(NOS2)
FCH: 102048023(NOS2)
CLV: 102086291(NOS2)
EGZ: 104121908(NOS2)
NNI: 104016248(NOS2)
ACUN: 113487234(NOS2)
PADL: 103912519(NOS2)
AAM: 106498669(NOS2)
ASN: 102375419(NOS2)
AMJ: 106737013(NOS2)
PSS: 102446334(NOS2)
CMY: 102946684(NOS2)
CPIC: 101941684(NOS2)
ACS: 100561200(nos2)
PVT: 110088446(NOS2)
PBI: 103051066(NOS2)
PMUR: 107296204(NOS2)
TSR: 106555338(NOS2)
PMUA: 114585803(NOS2)
GJA: 107119447(NOS2)
XLA: 108708038(nos2.L) 108708888(nos2.S)
XTR: 100494698(nos2)
NPR: 108801680(NOS2)
DRE: 404036(nos2a) 563654(nos2b)
IPU: 108277518(NOS2b2) 108278375(nos2)
EEE: 113591429
SASA: 100136358(nos2)
SALP: 111949918 111960727(nos2)
ELS: 105013989(nos2) 109615805
SFM: 108932266(nos2)
PKI: 111856407(nos2)
LCM: 102354990(NOS2)
CMK: 103183299(nos2)
RTP: 109927199(nos2)
CSCU: 111619022
 » show all
Reference
PMID:7682706
  Authors
Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR
  Title
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.
  Journal
Proc Natl Acad Sci U S A 90:3491-5 (1993)
DOI:10.1073/pnas.90.8.3491
  Sequence
[hsa:4843]

KEGG   ORTHOLOGY: K13242
Entry
K13242                      KO                                     

Name
NOS3
Definition
nitric-oxide synthase, endothelial [EC:1.14.13.39]
Pathway
ko00220  Arginine biosynthesis
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04066  HIF-1 signaling pathway
ko04071  Sphingolipid signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04611  Platelet activation
ko04915  Estrogen signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04931  Insulin resistance
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05418  Fluid shear stress and atherosclerosis
Disease
H01529  Avascular necrosis of femoral head
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13242  NOS3; nitric-oxide synthase, endothelial
   00330 Arginine and proline metabolism
    K13242  NOS3; nitric-oxide synthase, endothelial
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04371 Apelin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04066 HIF-1 signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04020 Calcium signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04071 Sphingolipid signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04022 cGMP-PKG signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04151 PI3K-Akt signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K13242  NOS3; nitric-oxide synthase, endothelial
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04921 Oxytocin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04926 Relaxin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K13242  NOS3; nitric-oxide synthase, endothelial
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13242  NOS3; nitric-oxide synthase, endothelial
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13242  NOS3; nitric-oxide synthase, endothelial
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
HSA: 4846(NOS3)
PTR: 463893(NOS3)
PPS: 100974638(NOS3)
GGO: 101128007(NOS3)
PON: 100447953(NOS3)
NLE: 100592456(NOS3)
MCC: 714231(NOS3)
MCF: 102143504(NOS3)
CSAB: 103227233(NOS3)
RRO: 104675393(NOS3)
RBB: 108532525(NOS3)
CJC: 100405019(NOS3)
SBQ: 101034220(NOS3)
MMU: 18127(Nos3)
MCAL: 110293897(Nos3)
MPAH: 110315110(Nos3)
RNO: 24600(Nos3)
MUN: 110562552(Nos3)
CGE: 100769961(Nos3)
NGI: 103745303(Nos3)
HGL: 101711110(Nos3)
CCAN: 109694442(Nos3)
OCU: 100009498(NOS3)
TUP: 102495986(NOS3)
CFA: 403784(NOS3)
VVP: 112916218(NOS3)
AML: 100483990(NOS3)
UMR: 103660958(NOS3)
UAH: 113241474(NOS3)
ORO: 101382350(NOS3)
ELK: 111154402
FCA: 101096463(NOS3)
PTG: 102967516(NOS3)
PPAD: 109252365(NOS3)
AJU: 106969560(NOS3)
BTA: 287024(NOS3)
BOM: 102267556(NOS3)
BIU: 109557793(NOS3)
BBUB: 102408451(NOS3)
CHX: 102185338(NOS3)
OAS: 443077(NOS3)
SSC: 397557(NOS3)
CFR: 102524296(NOS3)
CDK: 105105831(NOS3)
BACU: 103017861(NOS3)
LVE: 103087259(NOS3)
OOR: 101280520(NOS3)
DLE: 111176849(NOS3)
PCAD: 102985806(NOS3)
ECB: 100063339(NOS3)
EPZ: 103540937(NOS3)
EAI: 106823361(NOS3)
MYB: 102256555(NOS3)
MYD: 102764374(NOS3)
MNA: 107524933(NOS3)
HAI: 109389680(NOS3)
DRO: 112308288(NOS3)
PALE: 102879945(NOS3)
RAY: 107520319(NOS3)
MJV: 108391841(NOS3)
LAV: 100668912(NOS3)
TMU: 101356953
MDO: 100018035(NOS3)
SHR: 100913437(NOS3)
PCW: 110201937(NOS3)
OAA: 100091599(NOS3)
GGA: 107057170
MGP: 100545552
CJO: 107308662(NOS3)
TGU: 115493592(NOS3)
LSR: 110475121(NOS3)
PHI: 102112141(NOS3)
ETL: 114068013(NOS3)
FPG: 101918492(NOS3)
FCH: 102057360(NOS3)
ASN: 102381196(NOS3)
AMJ: 102575253(NOS3)
CMY: 102942806
CPIC: 101952927(NOS3)
ACS: 100557597(nos3)
PVT: 110082598(NOS3)
PBI: 103065136
TSR: 106544793(NOS3)
PMUA: 114607850(NOS3)
GJA: 107118610(NOS3)
XLA: 108704634(nos3.L)
XTR: 100486016(nos3)
NPR: 108803428
 » show all
Reference
PMID:1378832
  Authors
Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD
  Title
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.
  Journal
J Biol Chem 267:14519-22 (1992)
  Sequence
[hsa:4846]

KEGG   ORTHOLOGY: K13427
Entry
K13427                      KO                                     

Name
NOA1
Definition
nitric-oxide synthase, plant [EC:1.14.13.39]
Pathway
ko00220  Arginine biosynthesis
ko00330  Arginine and proline metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04626  Plant-pathogen interaction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13427  NOA1; nitric-oxide synthase, plant
   00330 Arginine and proline metabolism
    K13427  NOA1; nitric-oxide synthase, plant
 09150 Organismal Systems
  09159 Environmental adaptation
   04626 Plant-pathogen interaction
    K13427  NOA1; nitric-oxide synthase, plant
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03009 Ribosome biogenesis
    K13427  NOA1; nitric-oxide synthase, plant
   03029 Mitochondrial biogenesis
    K13427  NOA1; nitric-oxide synthase, plant
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13427  NOA1; nitric-oxide synthase, plant
Ribosome biogenesis [BR:ko03009]
 Eukaryotic type
  Other ribosome biogenesis factors
   K13427  NOA1; nitric-oxide synthase, plant
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    K13427  NOA1; nitric-oxide synthase, plant
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
ATH: AT3G47450(NOA1)
ALY: 9311909
CRB: 17885274
CSAT: 104711205 104780543 104790952
EUS: EUTSA_v10010252mg
BRP: 103873244
BNA: 106435290 106451204
BOE: 106336370
RSZ: 108805938
THJ: 104819450
CPAP: 110823388
CIT: 102609531
TCC: 18605348
GRA: 105764892
GAB: 108476635
DZI: 111291243
EGR: 104449744
VRA: 106779222
VAR: 108338876
VUN: 114168311
CCAJ: 109799300
CAM: 101502582
LJA: Lj3g3v3640230.1(Lj3g3v3640230.1) Lj3g3v3640230.2(Lj3g3v3640230.2)
ADU: 107477402
AIP: 107629644
LANG: 109346733
RCN: 112194641
PPER: 18787454
PMUM: 103333445
PAVI: 110764709
MDM: 103439617
CSV: 101215455
CMO: 103504692
MCHA: 111026165
CMAX: 111468852
CMOS: 111435614
CPEP: 111808842
RCU: 8289609
JCU: 105648618
MESC: 110609785
POP: 18094012
PEU: 105121408
JRE: 109021608
VVI: 100265605
SLY: 778272
SPEN: 107014849
SOT: 102577659
CANN: 107863453
NTA: 107785662 107819728(NOS1)
NSY: 104222140
NTO: 104094540
NAU: 109209591
INI: 109151404
SIND: 105160612
OEU: 111390921
HAN: 110915439
LSV: 111901618
CCAV: 112521376
DCR: 108219256
BVG: 104906620
SOE: 110782360
NNU: 104602366
OSA: 4328006
DOSA: Os02t0104700-01(Os02g0104700)
OBR: 102721991
BDI: 100824396
ATS: 109734442(LOC109734442)
SBI: 8066480
ZMA: 100381773
SITA: 101766392
PDA: 103710739
EGU: 105059520
MUS: 103973495
DCT: 110108324
PEQ: 110019759
AOF: 109822646
ATR: 18428833
PPP: 112284854
APRO: F751_5878
TAN: TA14095
 » show all
Reference
  Authors
Li JH, Liu YQ, Lu P, Lin HF, Bai Y, Wang XC, Chen YL
  Title
A signaling pathway linking nitric oxide production to heterotrimeric G protein and hydrogen peroxide regulates extracellular calmodulin induction of stomatal closure in Arabidopsis.
  Journal
Plant Physiol 150:114-24 (2009)
DOI:10.1104/pp.109.137067

KEGG   ENZYME: 1.14.13.39
Entry
EC 1.14.13.39               Enzyme                                 

Name
nitric-oxide synthase (NADPH);
NOS (gene name);
nitric oxide synthetase (ambiguous);
endothelium-derived relaxation factor-forming enzyme;
endothelium-derived relaxing factor synthase;
NO synthase (ambiguous);
NADPH-diaphorase (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Reaction(IUBMB)
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O (overall reaction) [RN:R00557];
(1a) 2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O  [RN:R00558];
(1b) 2 Nomega-hydroxy-L-arginine + NADPH + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP+ + 2 H2O [RN:R00111]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007];
Nomega-hydroxy-L-arginine
Product
L-citrulline [CPD:C00327];
nitric oxide [CPD:C00533];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
Nomega-hydroxy-L-arginine
Comment
The enzyme consists of linked oxygenase and reductase domains. The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. The reductase domain of the enzyme from the bacterium Sorangium cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from NADPH to the active center. cf. EC 1.14.14.47, nitric-oxide synthase (flavodoxin).
History
EC 1.14.13.39 created 1992, modified 2012, modified 2017
Pathway
ec00220  Arginine biosynthesis
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13240  nitric-oxide synthase, brain
K13241  nitric-oxide synthase, inducible
K13242  nitric-oxide synthase, endothelial
K13427  nitric-oxide synthase, plant
Genes
HSA: 4842(NOS1) 4843(NOS2) 4846(NOS3)
PTR: 455026(NOS2) 463893(NOS3) 467139(NOS1)
PPS: 100974638(NOS3) 100976546(NOS2) 100996089(NOS1)
GGO: 101128007(NOS3) 101134923(NOS2) 101147071(NOS1)
PON: 100433069(NOS1) 100436584(NOS2) 100447953(NOS3)
NLE: 100589003(NOS2) 100592456(NOS3) 100597250(NOS1)
MCC: 114673005 693781(NOS1) 706921(NOS2) 714231(NOS3)
MCF: 102121432(NOS2) 102123521(NOS1) 102143504(NOS3)
CSAB: 103227233(NOS3) 103242598 103242600(NOS2)
RRO: 104669357(NOS2) 104675393(NOS3) 104675533(NOS1)
RBB: 108532525(NOS3) 108539288(NOS1) 108539959(NOS2)
CJC: 100403192(NOS2) 100405019(NOS3) 100895717(NOS1)
SBQ: 101034220(NOS3) 101034544(NOS1) 101041016(NOS2)
MMU: 18125(Nos1) 18126(Nos2) 18127(Nos3)
MCAL: 110293897(Nos3) 110294416(Nos1) 110304621(Nos2)
MPAH: 110312876(Nos1) 110315110(Nos3) 110331408(Nos2)
RNO: 24598(Nos1) 24599(Nos2) 24600(Nos3) 497963
MUN: 110550157(Nos2) 110551884(Nos1) 110562552(Nos3)
CGE: 100758127(Nos1) 100760062(Nos2) 100769961(Nos3)
NGI: 103724501(Nos2) 103745303(Nos3) 103745523(Nos1)
HGL: 101699617(Nos2) 101711110(Nos3) 101711993(Nos1)
CCAN: 109686387(Nos1) 109693015(Nos2) 109694442(Nos3)
OCU: 100008833(NOS2) 100009243(NOS1) 100009498(NOS3)
TUP: 102471872(NOS2) 102480558(NOS1) 102495986(NOS3)
CFA: 403784(NOS3) 403822(NOS2) 477498(NOS1)
VVP: 112916218(NOS3) 112932933(NOS1) 112933146(NOS2)
AML: 100468087(NOS1) 100470060(NOS2) 100483990(NOS3)
UMR: 103660958(NOS3) 103661304(NOS1) 103667420(NOS2)
UAH: 113241474(NOS3) 113266817(NOS1) 113269018(NOS2)
ORO: 101375441(NOS1) 101380967(NOS2) 101382350(NOS3)
FCA: 101087020(NOS2) 101096463(NOS3) 101100342(NOS1)
PTG: 102950049(NOS2) 102962715(NOS1) 102967516(NOS3)
PPAD: 109251875(NOS2) 109252365(NOS3) 109277571(NOS1)
AJU: 106969560(NOS3) 106971710(NOS1) 106984382(NOS2)
BTA: 282876(NOS2) 287024(NOS3) 536132(NOS1)
BOM: 102265893(NOS2) 102267556(NOS3) 102280537(NOS1)
BIU: 109557793(NOS3) 109571319(NOS1) 109574459(NOS2)
BBUB: 102400136(NOS1) 102401026(NOS2) 102408451(NOS3)
CHX: 100860742(NOS2) 102185338(NOS3) 102185490(NOS1)
OAS: 443077(NOS3) 443078(NOS2) 443533(NOS1)
SSC: 100520934(NOS1) 396859(NOS2) 397557(NOS3)
CFR: 102508946(NOS1) 102518523(NOS2) 102524296(NOS3)
CDK: 105088198(NOS2) 105104911(NOS1) 105105831(NOS3)
BACU: 103003780(NOS2) 103008209(NOS1) 103017861(NOS3)
LVE: 103074308(NOS2) 103087259(NOS3) 103090138(NOS1)
OOR: 101273057(NOS1) 101280520(NOS3) 101280638(NOS2)
DLE: 111176849(NOS3) 111185989 111186931(NOS1)
PCAD: 102985806(NOS3) 102990905(NOS2) 102991967(NOS1)
ECB: 100051079(NOS1) 100063339(NOS3) 791246(NOS2)
EPZ: 103540937(NOS3) 103547950(NOS1) 103567002
EAI: 106823361(NOS3) 106839766(NOS1) 106844596(NOS2)
MYB: 102253125(NOS2) 102256555(NOS3) 102260489(NOS1)
MYD: 102763635(NOS1) 102764374(NOS3) 102768087(NOS2)
MNA: 107524933(NOS3) 107528483(NOS1) 107533063(NOS2)
HAI: 109382238(NOS1) 109385084(NOS2) 109389680(NOS3)
DRO: 112308288(NOS3) 112308600(NOS2) 112310614(NOS1)
PALE: 102878456(NOS2) 102879945(NOS3) 102884569(NOS1)
RAY: 107497410(NOS2) 107513162(NOS1) 107520319(NOS3)
MJV: 108391841(NOS3) 108397044(NOS2) 108397443(NOS1)
LAV: 100668912(NOS3) 100673992(NOS1) 100676634(NOS2)
MDO: 100013712(NOS1) 100018035(NOS3) 100024271(NOS2)
SHR: 100913437(NOS3) 100921140(NOS1) 100927789(NOS2)
PCW: 110192171(NOS2) 110201937(NOS3) 110222812(NOS1)
OAA: 100075386(NOS2) 100091599(NOS3) 100093259(NOS1)
GGA: 107057170 395807(NOS2) 427721(NOS1)
MGP: 100538441(NOS1) 100545552 692136(NOS2)
CJO: 107308662(NOS3) 107321466(NOS1) 107322733(NOS2)
NMEL: 110406170(NOS1) 110407551(NOS2)
APLA: 101798766(NOS1) 101804455(NOS2)
ACYG: 106043795(NOS2) 106045554(NOS1)
TGU: 100230954(NOS2) 100231414(NOS1) 115493592(NOS3) 116807264
LSR: 110471958(NOS2) 110474155(NOS1) 110475121(NOS3)
SCAN: 103818226(NOS1) 103820198(NOS2)
GFR: 102042821(NOS1) 102044468(NOS2)
FAB: 101817488(NOS2) 101820761(NOS1)
PHI: 102106809(NOS1) 102108817(NOS2) 102112141(NOS3)
PMAJ: 107211573(NOS1) 107212812(NOS2)
CCAE: 111936662(NOS1) 111937881(NOS2)
CCW: 104690967(NOS2) 104695038(NOS1)
ETL: 114057504(NOS2) 114068013(NOS3) 114071586(NOS1)
FPG: 101916747(NOS1) 101918492(NOS3) 101921726(NOS2)
FCH: 102047821(NOS1) 102048023(NOS2) 102057360(NOS3)
CLV: 102086291(NOS2) 102093432(NOS1)
EGZ: 104121908(NOS2) 104129871(NOS1)
NNI: 104010553(NOS1) 104016248(NOS2)
ACUN: 113486129(NOS1) 113487234(NOS2)
PADL: 103912519(NOS2) 103913684(NOS1)
AAM: 106493898(NOS1) 106498669(NOS2)
ASN: 102375419(NOS2) 102380334(NOS1) 102381196(NOS3)
AMJ: 102561243(NOS1) 102575253(NOS3) 106737013(NOS2)
PSS: 102444149(NOS1) 102446334(NOS2)
CMY: 102941829(NOS1) 102942806 102946684(NOS2)
CPIC: 101937660(NOS1) 101941684(NOS2) 101952927(NOS3)
ACS: 100557597(nos3) 100561200(nos2) 100562233(nos1)
PVT: 110082598(NOS3) 110088446(NOS2) 110090104(NOS1)
PBI: 103051066(NOS2) 103052972(NOS1) 103065136
PMUR: 107295430(NOS1) 107296204(NOS2)
TSR: 106544793(NOS3) 106555338(NOS2)
PMUA: 114585803(NOS2) 114587067(NOS1) 114607850(NOS3)
GJA: 107112296(NOS1) 107118610(NOS3) 107119447(NOS2)
XLA: 108704634(nos3.L) 108707179(nos1.S) 108708038(nos2.L) 108708888(nos2.S) 373705(nos1.L)
XTR: 100486016(nos3) 100494698(nos2) 100497595(nos1)
NPR: 108785232(NOS1) 108801680(NOS2) 108803428
DRE: 404036(nos2a) 563654(nos2b) 60658(nos1)
IPU: 108255344(nos1) 108277518(NOS2b2) 108278375(nos2)
EEE: 113577767(nos1) 113591429
TRU: 101066909(nos1)
LCO: 104923687(nos1)
NCC: 104967506(nos1)
MZE: 101485683(nos1)
ONL: 100534582(nos1)
OLA: 100049502(nos1)
XMA: 102233853(nos1)
XCO: 114154866(nos1)
PRET: 103469871(nos1)
CVG: 107087335(nos1)
NFU: 107386248(nos1)
KMR: 108246938(nos1)
ALIM: 106519449(nos1)
AOCE: 111572539(nos1)
CSEM: 103396877 103397851(nos1)
POV: 109637139(nos1)
LCF: 108903114(nos1)
SDU: 111227324(nos1)
SLAL: 111663111(nos1)
HCQ: 109525272(nos1)
BPEC: 110155016(nos1)
MALB: 109959109(nos1)
SASA: 100136358(nos2) 100136388(nos1) 106585241
ELS: 105013989(nos2) 105031277(nos1) 109615805
SFM: 108927312(nos1) 108932266(nos2)
PKI: 111851114 111852748(nos1) 111856407(nos2)
LCM: 102348281(NOS1) 102354990(NOS2)
CMK: 103183299(nos2) 103184386(nos1)
RTP: 109914181(nos1) 109922224 109927199(nos2)
CIN: 100183039
DME: Dmel_CG6713(Nos)
DER: 6542987
DSE: 6612066
DSI: Dsimw501_GD22223(Dsim_GD22223)
DAN: 6496893
DSR: 110183462
DPE: 6596585
DMN: 108163699
DWI: 6641760
DAZ: 108609612
DNV: 108658145
DHE: 111601524
DVI: 6629111
MDE: 101891936
LCQ: 111681704
AAG: 5572370
AME: 503861(NOS)
BIM: 100749227
BTER: 100650517
CCAL: 108625325
OBB: 114871710
SOC: 105200228
MPHA: 105829748
AEC: 105149468
ACEP: 105625167
PBAR: 105432905
VEM: 105557978
HST: 105183230
DQU: 106744004
CFO: 105250272
LHU: 105675559
PGC: 109856190
OBO: 105286125
PCF: 106793080
NVI: 100313941(Nos)
CSOL: 105360744
MDL: 103570884
TCA: 655549
DPA: 109546644
NVL: 108558954
BMOR: 100144542(NOS2) 692510(NOS1)
API: 100160390
DNX: 107172687
AGS: 114128082
RMD: 113551041
BTAB: 109031807
CLEC: 106661589
ZNE: 110828058
FCD: 110850636
TUT: 107370056
DPTE: 113792010
PTEP: 107440636
PCAN: 112563084
CRG: 105322950
MYI: 110460719
NVE: 5511062
EPA: 110253339
PDAM: 113685754
HMG: 101240122
ATH: AT3G47450(NOA1)
ALY: 9311909
CRB: 17885274
BRP: 103873244
BOE: 106336370
RSZ: 108805938
THJ: 104819450
CPAP: 110823388
CIT: 102609531
TCC: 18605348
GRA: 105764892
GAB: 108476635
DZI: 111291243
EGR: 104449744
VRA: 106779222
VAR: 108338876
VUN: 114168311
CCAJ: 109799300
CAM: 101502582
LJA: Lj3g3v3640230.1(Lj3g3v3640230.1) Lj3g3v3640230.2(Lj3g3v3640230.2)
ADU: 107477402
AIP: 107629644
LANG: 109346733
RCN: 112194641
PPER: 18787454
PMUM: 103333445
PAVI: 110764709
MDM: 103439617
CSV: 101215455
CMO: 103504692
MCHA: 111026165
CMAX: 111468852
CMOS: 111435614
CPEP: 111808842
RCU: 8289609
JCU: 105648618
MESC: 110609785
POP: 18094012
PEU: 105121408
JRE: 109021608
VVI: 100265605
SLY: 778272
SPEN: 107014849
SOT: 102577659
CANN: 107863453
NTA: 107785662 107819728(NOS1)
NSY: 104222140
NTO: 104094540
NAU: 109209591
INI: 109151404
SIND: 105160612
OEU: 111390921
HAN: 110915439
LSV: 111901618
CCAV: 112521376
DCR: 108219256
BVG: 104906620
SOE: 110782360
NNU: 104602366
OSA: 4328006
DOSA: Os02t0104700-01(Os02g0104700)
OBR: 102721991
BDI: 100824396
ATS: 109734442(LOC109734442)
SBI: 8066480
ZMA: 100381773
SITA: 101766392
PDA: 103710739
EGU: 105059520
MUS: 103973495
DCT: 110108324
PEQ: 110019759
AOF: 109822646
ATR: 18428833
PPP: 112284854
APRO: F751_5878
TAN: TA14095
 » show all
Reference
1  [PMID:1689048]
  Authors
Bredt DS, Snyder SH.
  Title
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
  Journal
Proc Natl Acad Sci U S A 87:682-5 (1990)
DOI:10.1073/pnas.87.2.682
Reference
2  [PMID:1706713]
  Authors
Stuehr DJ, Kwon NS, Nathan CF, Griffith OW, Feldman PL, Wiseman J
  Title
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
  Journal
J Biol Chem 266:6259-63 (1991)
Reference
3  [PMID:11279231]
  Authors
Stuehr D, Pou S, Rosen GM
  Title
Oxygen reduction by nitric-oxide synthases.
  Journal
J Biol Chem 276:14533-6 (2001)
DOI:10.1074/jbc.R100011200
Reference
4  [PMID:19805284]
  Authors
Agapie T, Suseno S, Woodward JJ, Stoll S, Britt RD, Marletta MA
  Title
NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum.
  Journal
Proc Natl Acad Sci U S A 106:16221-6 (2009)
DOI:10.1073/pnas.0908443106
Reference
5  [PMID:21119059]
  Authors
Foresi N, Correa-Aragunde N, Parisi G, Calo G, Salerno G, Lamattina L
  Title
Characterization of a nitric oxide synthase from the plant kingdom: NO generation from the green alga Ostreococcus tauri is light irradiance and growth phase dependent.
  Journal
Plant Cell 22:3816-30 (2010)
DOI:10.1105/tpc.109.073510
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.39
IUBMB Enzyme Nomenclature: 1.14.13.39
ExPASy - ENZYME nomenclature database: 1.14.13.39
BRENDA, the Enzyme Database: 1.14.13.39
CAS: 125978-95-2

KEGG   REACTION: R00557
Entry
R00557                      Reaction                               

Name
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Definition
2 L-Arginine + 4 Oxygen + 3 NADPH + 3 H+ <=> 2 Nitric oxide + 2 L-Citrulline + 3 NADP+ + 4 H2O
Equation
2 C00062 + 4 C00007 + 3 C00005 + 3 C00080 <=> 2 C00533 + 2 C00327 + 3 C00006 + 4 C00001
Comment
multi-step reaction (see R00558+R00111)
NADH (see R10106)
Reaction class
RC00001  C00005_C00006
RC00177  C00062_C00327
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13427  nitric-oxide synthase, plant [EC:1.14.13.39]
Other DBs
RHEA: 19900

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