KEGG   ORTHOLOGY: K13308Help
Entry
K13308                      KO                                     

Name
desI, eryCIV
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00797  dTDP-D-desosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13308  desI, eryCIV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K13308  desI, eryCIV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
BRITE hierarchy
Other DBs
RN: R02773
COG: COG0399
GO: 0019179
Genes
STRE: GZL_03714
SXI: SXIM_35940
STRM: M444_29855
SNR: SNOUR_10120(eryCIV)
AER: AERYTH_15840
SEN: SACE_0716(eryCIV)
KAL: KALB_4714 KALB_6578(acuN2)
STP: Strop_2221
AEY: CDG81_13210
AG: AAC68684(desI)
TaxonomyKoalaUniProt
Reference
  Authors
Burgie ES, Holden HM
  Title
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.
  Journal
Biochemistry 46:8999-9006 (2007)
DOI:10.1021/bi700751d
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence

KEGG   ORTHOLOGY: K20428Help
Entry
K20428                      KO                                     

Name
acbV
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20428  acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K20428  acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
BRITE hierarchy
Other DBs
RN: R02773
COG: COG0160 COG4992
GO: 0019179
Genes
CJA: CJA_3257
SUR: STAUR_1378(gacV)
SGU: SGLAU_00985(gacV)
ASE: ACPL_3667(acbV)
MOX: DAMO_2610
TaxonomyKoalaUniProt
Reference
  Authors
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
  Title
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
  Journal
J Biotechnol 167:178-89 (2013)
DOI:10.1016/j.jbiotec.2012.08.011
  Sequence
[ase:ACPL_3667]

KEGG   ENZYME: 2.6.1.33Help
Entry
EC 2.6.1.33                 Enzyme                                 

Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase;
thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase;
thymidine diphospho-4-amino-6-deoxyglucose aminotransferase;
thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
VioA;
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate [RN:R02773]
Reaction(KEGG)
R02773;
(other) R02772
Show
Substrate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose [CPD:C04268];
2-oxoglutarate [CPD:C00026]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein.
History
EC 2.6.1.33 created 1972
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Genes
ECT: ECIAI39_0979(vioA)
EOC: CE10_2353(vioA)
EBR: ECB_01942(vioA)
EBD: ECBD_1619
EBL: ECD_01942(vioA)
EBE: B21_01931(ybl97)
SHQ: A0259_14015
PAY: PAU_04327(vioA)
HAV: AT03_13955
SHE: Shewmr4_1321
CJA: CJA_3257
SUR: STAUR_1378(gacV)
SGU: SGLAU_00985(gacV)
STRE: GZL_03714
STRM: M444_29855
SNR: SNOUR_10120(eryCIV)
SEN: SACE_0716(eryCIV)
KAL: KALB_4714 KALB_6578(acuN2)
ASE: ACPL_3667(acbV)
MOX: DAMO_2610
 » show all
Taxonomy
Reference
1  [PMID:5332731]
  Authors
Matsuhashi M, Strominger JL.
  Title
Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B.
  Journal
J Biol Chem 241:4738-44 (1966)
Reference
2  [PMID:17905981]
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.33
IUBMB Enzyme Nomenclature: 2.6.1.33
ExPASy - ENZYME nomenclature database: 2.6.1.33
BRENDA, the Enzyme Database: 2.6.1.33
CAS: 9023-19-2

KEGG   REACTION: R02773Help
Entry
R02773                      Reaction                               

Name
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <=> dTDP-4-oxo-6-deoxy-D-glucose + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026
RC00781  C04268_C11907
Enzyme
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00797  dTDP-D-desosamine biosynthesis
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Other DBs
RHEA: 19088

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