KEGG   ORTHOLOGY: K13308
Entry
K13308                      KO                                     

Name
desI, eryCIV
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00797  dTDP-D-desosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13308  desI, eryCIV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K13308  desI, eryCIV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Other DBs
RN: R02773
COG: COG0399
GO: 0019179
Genes
STRE: GZL_03714
SXI: SXIM_35940
STRM: M444_29855
SNR: SNOUR_10120(eryCIV)
AER: AERYTH_15840
SEN: SACE_0716(eryCIV)
KAL: KALB_4714 KALB_6578(acuN2)
STP: Strop_2221
MCAB: HXZ27_06180(rosQ)
AEY: CDG81_13210
AG: AAC68684(desI)
 » show all
Reference
  Authors
Burgie ES, Holden HM
  Title
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.
  Journal
Biochemistry 46:8999-9006 (2007)
DOI:10.1021/bi700751d
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence

KEGG   ORTHOLOGY: K21328
Entry
K21328                      KO                                     

Name
calS13, atmS13
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21328  calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K21328  calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
    2.6.1.-  
     K21328  calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Other DBs
RN: R02773 R11475
COG: COG0399
Genes
SAQ: Sare_2034 Sare_2945
AG: AAM94797(calS13) ABC02793(atmS13)
Reference
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
Reference
  Authors
Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr
  Title
Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.
  Journal
Proteins 83:1547-54 (2015)
DOI:10.1002/prot.24844
Reference
PMID:12183629 (calS13)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
PMID:16873021 (atmS13)
  Authors
Gao Q, Zhang C, Blanchard S, Thorson JS
  Title
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.
  Journal
Chem Biol 13:733-43 (2006)
DOI:10.1016/j.chembiol.2006.05.009
  Sequence

KEGG   ORTHOLOGY: K20428
Entry
K20428                      KO                                     

Name
acbV
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
ko00525  Acarbose and validamycin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20428  acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K20428  acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Other DBs
RN: R02773
COG: COG0160 COG4992
GO: 0019179
Genes
CJA: CJA_3257
SUR: STAUR_1378(gacV)
SGU: SGLAU_00985(gacV)
ASE: ACPL_3667(acbV)
MOX: DAMO_2610
Reference
  Authors
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
  Title
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
  Journal
J Biotechnol 167:178-89 (2013)
DOI:10.1016/j.jbiotec.2012.08.011
  Sequence
[ase:ACPL_3667]

KEGG   ENZYME: 2.6.1.33
Entry
EC 2.6.1.33                 Enzyme                                 

Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase;
thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase;
thymidine diphospho-4-amino-6-deoxyglucose aminotransferase;
thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
VioA;
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate [RN:R02773]
Reaction(KEGG)
R02773;
(other) R02772
Substrate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose [CPD:C04268];
2-oxoglutarate [CPD:C00026]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein.
History
EC 2.6.1.33 created 1972
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00525  Acarbose and validamycin biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Genes
ECT: ECIAI39_0979(vioA)
EOC: CE10_2353(vioA)
EBR: ECB_01942(vioA)
EBL: ECD_01942(vioA)
EBE: B21_01931(ybl97)
EBD: ECBD_1619
SHQ: A0259_14015
ESH: C1N69_14925
PAY: PAU_04327(vioA)
HAV: AT03_13955
CJA: CJA_3257
SUR: STAUR_1378(gacV)
SGU: SGLAU_00985(gacV)
STRE: GZL_03714
STRM: M444_29855
SNR: SNOUR_10120(eryCIV)
SEN: SACE_0716(eryCIV)
KAL: KALB_4714 KALB_6578(acuN2)
MCAB: HXZ27_06180(rosQ)
ASE: ACPL_3667(acbV)
MOX: DAMO_2610
 » show all
Reference
1  [PMID:5332731]
  Authors
Matsuhashi M, Strominger JL.
  Title
Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B.
  Journal
J Biol Chem 241:4738-44 (1966)
Reference
2  [PMID:17905981]
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.33
IUBMB Enzyme Nomenclature: 2.6.1.33
ExPASy - ENZYME nomenclature database: 2.6.1.33
BRENDA, the Enzyme Database: 2.6.1.33
CAS: 9023-19-2

KEGG   REACTION: R02773
Entry
R02773                      Reaction                               

Name
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <=> dTDP-4-oxo-6-deoxy-D-glucose + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026
RC00781  C04268_C11907
Enzyme
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00797  dTDP-D-desosamine biosynthesis
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Other DBs
RHEA: 19088

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