KEGG   ORTHOLOGY: K13315Help
Entry
K13315                      KO                                     

Name
eryBII, tylCII, tylC1, calS12, atmS12
Definition
NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase [EC:1.1.1.-]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00798  dTDP-L-mycarose biosynthesis
M00799  dTDP-L-oleandrose biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13315  eryBII, tylCII, tylC1, calS12, atmS12; NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K13315  eryBII, tylCII, tylC1, calS12, atmS12; NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase
BRITE hierarchy
Other DBs
RN: R11051 R11474
COG: COG0656 COG0667
Genes
NTP: CRH09_07940
SALB: XNR_0575
SMA: SAVERM_952(aveBVIII)
SVL: Strvi_3808
SALS: SLNWT_7314
SRC: M271_06425
SAMB: SAM23877_5605(srm32)
SNR: SNOUR_10085
STRD: NI25_08110
SAUO: BV401_39265
SMAL: SMALA_7127
SALJ: SMD11_1675
NDA: Ndas_4717
SEN: SACE_0727(eryBII)
ACTI: UA75_16850
SAQ: Sare_2035
MIL: ML5_0703
AG: AAD41821(tylCII) AAG13914(MegBIIb) AAG13922(MegBIIa) AAM70349(calS12) ABC02798(atmS12)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139
  Sequence
Reference
  Authors
Takahashi H, Liu YN, Chen H, Liu HW
  Title
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.
  Journal
J Am Chem Soc 127:9340-1 (2005)
DOI:10.1021/ja051409x

KEGG   REACTION: R11474Help
Entry
R11474                      Reaction                               

Name
dTDP-4-oxo-2-deoxy-beta-L-xylose:NADP+ oxidoreductase
Definition
dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene + NADPH + H+ <=> dTDP-4-oxo-2-deoxy-beta-L-xylose + NADP+
Equation
Comment
deduced reaction
Reaction class
RC01516  C21352_C21353
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K13315  NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase [EC:1.1.1.-]

DBGET integrated database retrieval system