KEGG   ORTHOLOGY: K13322
Entry
K13322                      KO                                     

Name
megDV
Definition
dTDP-4-keto-6-deoxyhexose 4-ketoreductase
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00800  dTDP-L-megosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13322  megDV; dTDP-4-keto-6-deoxyhexose 4-ketoreductase
Other DBs
RN: R11047
Genes
AMS: AMIS_50620
AG: AAG13913(megDV)
Reference
  Authors
Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H
  Title
TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.
  Journal
Appl Environ Microbiol 76:3869-77 (2010)
DOI:10.1128/AEM.03083-09
Reference
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
DOI:10.1046/j.1365-2958.2000.02059.x
  Sequence

KEGG   REACTION: R11047
Entry
R11047                      Reaction                               

Definition
dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose <=> dTDP-L-megosamine
Equation
Reaction class
RC00182  C11919_C21074
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00800  dTDP-L-megosamine biosynthesis
Orthology
K13322  dTDP-4-keto-6-deoxyhexose 4-ketoreductase

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