KEGG   ORTHOLOGY: K13537
Entry
K13537                      KO                                     

Name
CPB
Definition
cysteine peptidase B [EC:3.4.22.-]
Pathway
ko05140  Leishmaniasis
ko05143  African trypanosomiasis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K13537  CPB; cysteine peptidase B
   05143 African trypanosomiasis
    K13537  CPB; cysteine peptidase B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K13537  CPB; cysteine peptidase B
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.-  
     K13537  CPB; cysteine peptidase B
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C1: papain family
   K13537  CPB; cysteine peptidase B
Genes
TBR: Tb927.6.1000 Tb927.6.1010 Tb927.6.1020 Tb927.6.1030 Tb927.6.1040 Tb927.6.1050 Tb927.6.1060 Tb927.6.960 Tb927.6.970 Tb927.6.980 Tb927.6.990
LMA: LMJF_08_1010 LMJF_08_1020 LMJF_08_1030 LMJF_08_1040 LMJF_08_1050 LMJF_08_1060 LMJF_08_1070 LMJF_08_1080
LIF: LINJ_08_0950 LINJ_08_0960
LDO: LDBPK_080960
LMI: LmxM_08_1040_1
LBZ: LBRM_08_0810(CPB) LBRM_08_0820(CPB) LBRM_08_0830(CPB)
LPAN: LPMP_080870(CPB)
Reference
  Authors
Cameron P, McGachy A, Anderson M, Paul A, Coombs GH, Mottram JC, Alexander J, Plevin R
  Title
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway.
  Journal
J Immunol 173:3297-304 (2004)
DOI:10.4049/jimmunol.173.5.3297
Reference
  Authors
Pollock KG, McNeil KS, Mottram JC, Lyons RE, Brewer JM, Scott P, Coombs GH, Alexander J
  Title
The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses.
  Journal
J Immunol 170:1746-53 (2003)
DOI:10.4049/jimmunol.170.4.1746

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