KEGG   ORTHOLOGY: K13548
Entry
K13548                      KO                                     
Symbol
neoA, kanK
Name
2-deoxy-scyllo-inosamine dehydrogenase [EC:1.1.1.329]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08892  2-deoxy-scyllo-inosamine:NAD+ oxidoreductase
R10130  2-deoxy-scyllo-inosamine:NADP+ 1-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K13548  neoA, kanK; 2-deoxy-scyllo-inosamine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.329  2-deoxy-scyllo-inosamine dehydrogenase
     K13548  neoA, kanK; 2-deoxy-scyllo-inosamine dehydrogenase
Genes
JAV: OXU80_01100
NIE: KV110_24020
SRN: A4G23_05130(neoA)
SFB: CP974_27375
SOV: QZH56_04530
SLUO: PS467_09025
DVC: Dvina_05415
AG: BAD95818(neoA) CAF60530(kanK)
Reference
PMID:16506694 (neoA)
  Authors
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K
  Title
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
  Journal
J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104
  Sequence
[ag:BAD95818]
Reference
PMID:15313224 (kanK)
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
[ag:CAF60530]
Reference
PMID:19362652
  Authors
Kudo F, Eguchi T
  Title
Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.
  Journal
Methods Enzymol 459:493-519 (2009)
DOI:10.1016/S0076-6879(09)04620-5

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (10)   
   KEGG GENES (9)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (23)   

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