| Entry |
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| Name |
13-hydroxylupanine O-tigloyltransferase;
tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase;
13-hydroxylupanine acyltransferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
(E)-2-methylcrotonoyl-CoA:13-hydroxylupanine O-2-methylcrotonoyltransferase
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| Reaction(IUBMB) |
(E)-2-methylcrotonoyl-CoA + 13-hydroxylupanine = CoA + 13-[(E)-2-methylcrotonoyl]oxylupanine [RN: R04205]
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| Reaction(KEGG) |
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| Substrate |
(E)-2-methylcrotonoyl-CoA [CPD: C03345];
13-hydroxylupanine [CPD: C02621]
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| Product |
CoA [CPD: C00010];
13-[(E)-2-methylcrotonoyl]oxylupanine
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| Comment |
Benzoyl-CoA and, more slowly, pentanoyl-CoA, 3-methylbutanoyl-CoA and butanoyl-CoA can act as acyl donors. Involved in the synthesis of lupanine alkaloids.
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| History |
EC 2.3.1.93 created 1986, modified 2011
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| Pathway |
| ec00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
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| Orthology |
| K13610 | 13-hydroxylupinine O-tigloyltransferase |
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| Reference |
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| Authors |
Wink M, Hartmann T |
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| Title |
Enzymatic synthesis of quinolizidine alkaloid esters: a tigloyl-CoA: 13-hydroxylupanine O-tigloyltransferase from Lupinus albus L. |
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| Journal |
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| Reference |
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| Authors |
Okada T, Hirai MY, Suzuki H, Yamazaki M, Saito K |
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| Title |
Molecular characterization of a novel quinolizidine alkaloid O-tigloyltransferase: cDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plants. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Suzuki H, Murakoshi I, Saito K. |
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| Title |
A novel O-tigloyltransferase for alkaloid biosynthesis in plants. Purification, characterization, and distribution in Lupinus plants. |
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| Journal |
J Biol Chem 269:15853-60 (1994) |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.3.1.93 |
| ExPASy - ENZYME nomenclature database: | 2.3.1.93 |
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