| Entry |
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| Name |
carboxynorspermidine synthase;
carboxynorspermidine dehydrogenase;
carboxyspermidine dehydrogenase;
CASDH;
CANSDH;
VC1624 (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
carboxynorspermidine:NADP+ oxidoreductase
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| Reaction(IUBMB) |
(1) carboxynorspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ [RN: R09080];
(2) carboxyspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + putrescine + NADPH + H+ [RN: R09079]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3].
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| History |
EC 1.5.1.43 created 2012
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| Pathway |
| ec00330 | Arginine and proline metabolism |
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| Orthology |
| K13746 | carboxynorspermidine synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Nakao H, Shinoda S, Yamamoto S |
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| Title |
Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus. |
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| Journal |
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| Reference |
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| Authors |
Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ |
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| Title |
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ |
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| Title |
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.1.43 |
| ExPASy - ENZYME nomenclature database: | 1.5.1.43 |
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