KEGG   ORTHOLOGY: K13746
Entry
K13746                      KO                                     
Symbol
cansdh
Name
carboxynorspermidine synthase [EC:1.5.1.43]
Pathway
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
Reaction
R09079  carboxyspermidine:NADP+ oxidoreductase
R09080  carboxynorspermidine:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K13746  cansdh; carboxynorspermidine synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.43  carboxynorspermidine synthase
     K13746  cansdh; carboxynorspermidine synthase
Other DBs
COG: COG1748
Genes
VCH: VC_1624
VCF: IR04_13345
VCS: MS6_1406
VCE: Vch1786_I1124
VCQ: EN18_11315
VCJ: VCD_002750
VCI: O3Y_07890
VCO: VC0395_A1231
VCR: VC395_1742
VCM: VCM66_1564
VCL: VCLMA_A1414
VCX: VAA049_1179
VCZ: VAB027_2272
VVU: VV1_3049
VVY: VV1237
VVM: VVMO6_01981
VVL: VV93_v1c11570
VPA: VP1941
VPB: VPBB_1783
VPK: M636_12125
VPF: M634_11915
VPH: VPUCM_1277
VHA: VIBHAR_02740
VCA: M892_17165
VAG: N646_1023
VEX: VEA_003102
VDB: AL552_18365
VHR: AL538_03275
VNA: PN96_04020
VOW: A9237_14585
VRO: BSZ04_17205
VSP: VS_1946
VEJ: VEJY3_10185
VFU: vfu_A01725
VNI: VIBNI_A2071
VAN: VAA_01989
LAG: N175_09070
VAU: VANGNB10_cI1167
VCY: IX92_08260
VCT: JV59_30255
VTU: IX91_08420
VEU: IXK98_17040
VSI: MTO69_05985
VFL: AL536_12655
VMI: AL543_17380
VBR: A6E01_05850
VSC: VSVS12_01829
VGA: BSQ33_00500
VSH: BSZ05_00395
VQI: CCZ37_05955
VTA: A0392
VAF: D1115_09535
VNL: D3H41_10620
VCC: FAZ90_05960
VAS: GT360_07755
VAQ: FIV01_08110
VSR: Vspart_01602
VKA: BTD91_00725
VZI: G5S32_08265
VNV: IF132_09435
VGI: MID13_09680
VSL: LTQ54_14800
VPL: SA104470976_01356
VJP: NP165_05960
VPG: LZI70_01375
VOS: KNV97_10195
VTI: CEQ48_10950
VCRA: IS519_00195
VNP: KW548_09380
VLE: ISX51_07305
VSY: K08M4_18330
VRU: RND59_14150
VMT: QYQ96_06075
VIB: VspSTUT11_10600
VIS: VspSTUT16_11410
VIO: AB2S62_08390
VIH: AB0763_07545
VCK: PG915_06665
VID: DBX26_09045
VIP: H9L11_00915
VSA: VSAL_I2137
AWD: AWOD_I_1745
PPR: PBPRA2229(RB1550)
PGB: H744_2c1553
PGH: FH974_09550
PHOT: L4174_006740
PATE: NNL38_06090
GHO: AL542_15065
GKD: K6Q96_11285
PMAI: CF386_00310
ELUX: BTN50_0370
PLAS: NF212_24115
PIN: Ping_2289
PSY: PCNPT3_08250
MVS: MVIS_2445
MYA: MORIYA_0602
MMAA: FR932_05520
MOQ: HWV03_09915
 » show all
Reference
PMID:19196710
  Authors
Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ
  Title
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.
  Journal
J Biol Chem 284:9899-907 (2009)
DOI:10.1074/jbc.M900110200
  Sequence
[vch:VC_1624]

  All links  
Ontology (1)   
   COG (1)   
Gene (17)   
   MGENES (16)   
   OC (1)   
All databases (18)   

Download RDF
KEGG   ENZYME: 1.5.1.43
Entry
EC 1.5.1.43                 Enzyme                                 
Name
carboxynorspermidine synthase;
carboxynorspermidine dehydrogenase;
carboxyspermidine dehydrogenase;
CASDH;
CANSDH;
VC1624 (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
carboxynorspermidine:NADP+ oxidoreductase
Reaction(IUBMB)
(1) carboxynorspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ [RN:R09080];
(2) carboxyspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + putrescine + NADPH + H+ [RN:R09079]
Reaction(KEGG)
R09079 R09080
Substrate
carboxynorspermidine [CPD:C18174];
H2O [CPD:C00001];
NADP+ [CPD:C00006];
carboxyspermidine [CPD:C18172]
Product
L-aspartate 4-semialdehyde [CPD:C00441];
propane-1,3-diamine [CPD:C00986];
NADPH [CPD:C00005];
H+ [CPD:C00080];
putrescine [CPD:C00134]
Comment
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3].
History
EC 1.5.1.43 created 2012
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K13746  carboxynorspermidine synthase
Genes
VCH: VC_1624
VCF: IR04_13345
VCS: MS6_1406
VCE: Vch1786_I1124
VCQ: EN18_11315
VCJ: VCD_002750
VCI: O3Y_07890
VCO: VC0395_A1231
VCR: VC395_1742
VCM: VCM66_1564
VCL: VCLMA_A1414
VCX: VAA049_1179
VCZ: VAB027_2272
VVU: VV1_3049
VVY: VV1237
VVM: VVMO6_01981
VVL: VV93_v1c11570
VPA: VP1941
VPB: VPBB_1783
VPK: M636_12125
VPF: M634_11915
VPH: VPUCM_1277
VHA: VIBHAR_02740
VCA: M892_17165
VAG: N646_1023
VEX: VEA_003102
VDB: AL552_18365
VHR: AL538_03275
VNA: PN96_04020
VOW: A9237_14585
VRO: BSZ04_17205
VSP: VS_1946
VEJ: VEJY3_10185
VFU: vfu_A01725
VNI: VIBNI_A2071
VAN: VAA_01989
LAG: N175_09070
VAU: VANGNB10_cI1167
VCY: IX92_08260
VCT: JV59_30255
VTU: IX91_08420
VEU: IXK98_17040
VSI: MTO69_05985
VFL: AL536_12655
VMI: AL543_17380
VBR: A6E01_05850
VSC: VSVS12_01829
VGA: BSQ33_00500
VSH: BSZ05_00395
VQI: CCZ37_05955
VTA: A0392
VAF: D1115_09535
VNL: D3H41_10620
VCC: FAZ90_05960
VAS: GT360_07755
VAQ: FIV01_08110
VSR: Vspart_01602
VKA: BTD91_00725
VZI: G5S32_08265
VNV: IF132_09435
VGI: MID13_09680
VSL: LTQ54_14800
VPL: SA104470976_01356
VJP: NP165_05960
VPG: LZI70_01375
VOS: KNV97_10195
VTI: CEQ48_10950
VCRA: IS519_00195
VNP: KW548_09380
VLE: ISX51_07305
VSY: K08M4_18330
VRU: RND59_14150
VMT: QYQ96_06075
VIB: VspSTUT11_10600
VIS: VspSTUT16_11410
VIO: AB2S62_08390
VIH: AB0763_07545
VCK: PG915_06665
VID: DBX26_09045
VIP: H9L11_00915
VSA: VSAL_I2137
AWD: AWOD_I_1745
PPR: PBPRA2229(RB1550)
PGB: H744_2c1553
PGH: FH974_09550
PHOT: L4174_006740
PATE: NNL38_06090
GHO: AL542_15065
GKD: K6Q96_11285
PMAI: CF386_00310
ELUX: BTN50_0370
PLAS: NF212_24115
PIN: Ping_2289
PSY: PCNPT3_08250
MVS: MVIS_2445
MYA: MORIYA_0602
MMAA: FR932_05520
MOQ: HWV03_09915
 » show all
Reference
1  [PMID:1955861]
  Authors
Nakao H, Shinoda S, Yamamoto S
  Title
Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus.
  Journal
J Gen Microbiol 137:1737-42 (1991)
DOI:10.1099/00221287-137-7-1737
Reference
2  [PMID:19196710]
  Authors
Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ
  Title
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.
  Journal
J Biol Chem 284:9899-907 (2009)
DOI:10.1074/jbc.M900110200
  Sequence
[vch:VC_1624]
Reference
3  [PMID:22025614]
  Authors
Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ
  Title
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
  Journal
J Biol Chem 286:43301-12 (2011)
DOI:10.1074/jbc.M111.307835
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.43
IUBMB Enzyme Nomenclature: 1.5.1.43
ExPASy - ENZYME nomenclature database: 1.5.1.43
BRENDA, the Enzyme Database: 1.5.1.43

  All links  
Gene (16)   
   MGENES (16)   
Protein sequence (1542)   
   UniProt (366)   
   SWISS-PROT (2)   
   RefSeq(pep) (1174)   
DNA sequence (10691)   
   RefSeq(nuc) (9156)   
   GenBank (780)   
   EMBL (755)   
Protein domain (4)   
   InterPro (4)   
All databases (12253)   

Download RDF
KEGG   REACTION: R09080
Entry
R09080                      Reaction                               
Name
carboxynorspermidine:NADP+ oxidoreductase
Definition
1,3-Diaminopropane + L-Aspartate 4-semialdehyde + NADPH + H+ <=> Carboxynorspermidine + H2O + NADP+
Equation
C00986 + C00441 + C00005 + C00080 <=> C18174 + C00001 + C00006
Reaction class
RC00001  C00005_C00006
RC00053  C00986_C18174
RC00225  C00441_C18174
Enzyme
1.5.1.43
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.43
     R09080  1,3-Diaminopropane + L-Aspartate 4-semialdehyde + NADPH + H+ <=> Carboxynorspermidine + H2O + NADP+
Orthology
K13746  carboxynorspermidine synthase [EC:1.5.1.43]
Other DBs
RHEA: 34118

  All links  
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