KEGG ORTHOLOGY: K14021

ORTHOLOGY: K14021

Entry

K14021                      KO

Symbol

BAK, BAK1

Name

Bcl-2 homologous antagonist/killer

Pathway

map01524

Platinum drug resistance

map04141

Protein processing in endoplasmic reticulum

map04210

Apoptosis

map04215

Apoptosis - multiple species

map05022

Pathways of neurodegeneration - multiple diseases

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05160

Hepatitis C

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05203

Viral carcinogenesis

map05206

MicroRNAs in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05214

Glioma

map05216

Thyroid cancer

map05217

Basal cell carcinoma

map05218

Melanoma

map05220

Chronic myeloid leukemia

map05222

Small cell lung cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   04215 Apoptosis - multiple species
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05202 Transcriptional misregulation in cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05206 MicroRNAs in cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05203 Viral carcinogenesis
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
  09162 Cancer: specific types
   05210 Colorectal cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05212 Pancreatic cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05225 Hepatocellular carcinoma
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05226 Gastric cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05214 Glioma
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05216 Thyroid cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05220 Chronic myeloid leukemia
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05217 Basal cell carcinoma
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05218 Melanoma
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05213 Endometrial cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05224 Breast cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05222 Small cell lung cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05223 Non-small cell lung cancer
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05160 Hepatitis C
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05164 Influenza A
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05162 Measles
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05168 Herpes simplex virus 1 infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05163 Human cytomegalovirus infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05167 Kaposi sarcoma-associated herpesvirus infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05169 Epstein-Barr virus infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05165 Human papillomavirus infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
   05132 Salmonella infection
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
  09164 Neurodegenerative disease
   05022 Pathways of neurodegeneration - multiple diseases
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer

Other DBs

TC:	1.A.21.1.3

Genes

HSA:

578(BAK1)

PTR:	462616(BAK1)

PPS:	100983246(BAK1)

PON:	100432001(BAK1) 100460189

PPYG:

129011548 129037905(BAK1)

NLE:	100588483(BAK1)

HMH:	116459971(BAK1) 116813623

SSYN:

129473785(BAK1)

MCC:	114675515 706534(BAK1)

MCF:	102142357(BAK1)

MTHB:

126952802

MNI:	105474465(BAK1)

CSAB:

103221651(BAK1)

CATY:

105593255(BAK1)

PANU:

101000115(BAK1)

TGE:	112622824(BAK1)

MLEU:

105544178(BAK1)

RRO:	104658958(BAK1)

RBB:	108516259(BAK1)

TFN:	117087056(BAK1) 117096195

PTEH:

111542928(BAK1)

CANG:

105514219(BAK1)

CJC:	100387945(BAK1)

SBQ:	101041291(BAK1)

CIMI:

108300037(BAK1)

ANAN:

105723556(BAK1)

CSYR:

103262464(BAK1)

MMUR:

105861442(BAK1)

LCAT:

123632819(BAK1)

PCOQ:

105821684(BAK1)

OGA:	100941755(BAK1)

MMU:	12018(Bak1)

MCAL:

110283660(Bak1)

MPAH:

110338169(Bak1)

RNO:	116502(Bak1)

MCOC:

116075029(Bak1)

ANU:	117724492(Bak1)

MUN:	110543676(Bak1)

CGE:	100689368(Bak1)

MAUA:

101838274(Bak1)

PROB:

127224244(Bak1)

PLEU:

114706143(Bak1)

MORG:

121435620(Bak1)

MFOT:

126499837

AAMP:

119823918(Bak1)

NGI:	103739733(Bak1)

HGL:	101707336(Bak1)

CPOC:

100734553(Bak1)

CCAN:

109686692(Bak1)

DORD:

105999887(Bak1)

DSP:	122111128(Bak1)

PLOP:

125352692(Bak1)

NCAR:

124974602 124988289 124988679

MMMA:

107143808(Bak1)

OCU:

100342046

OPI:	101516199(BAK1)

TUP:	102476690(BAK1)

GVR:	103599851(BAK1)

CFA:	481744(BAK1)

CLUD:

112641425(BAK1)

VVP:	112913897(BAK1)

VLG:	121497413(BAK1)

NPO:	129513046(BAK1)

AML:	100472241(BAK1)

UMR:	103665481(BAK1)

UAH:	113243812(BAK1)

UAR:	123790912(BAK1)

ELK:

111152355

LLV:

125102734

MPUF:

101688916(BAK1)

MNP:	132017889(BAK1)

MLK:	131834235(BAK1)

NVS:	122910577(BAK1)

ORO:	101380231(BAK1)

EJU:	114222181(BAK1)

ZCA:	113927365(BAK1)

MLX:	118000738(BAK1)

NSU:	110575593(BAK1)

LWW:	102731986(BAK1)

FCA:	101093435(BAK1)

PYU:	121029294(BAK1)

PCOO:

112861960(BAK1)

PBG:	122489414(BAK1)

PVIV:

125166045(BAK1)

LRUF:

124528274

PTG:	102970767(BAK1)

PPAD:

109271451(BAK1)

PUC:

125938359

AJU:

106976101

HHV:	120238211(BAK1)

BTA:	514090(BAK1)

BOM:	102266544(BAK1)

BIU:	109577301(BAK1)

BBUB:

102403948(BAK1)

BBIS:

104994906(BAK1)

CHX:	102170562(BAK1)

OAS:	443062(BAK1)

BTAX:

128056082(BAK1)

ODA:	120869828(BAK1)

CCAD:

122430151(BAK1)

MBEZ:

129543626(BAK1)

SSC:	397543(BAK1)

CFR:	102513729(BAK1)

CBAI:

105064215(BAK1)

CDK:	105101376(BAK1)

VPC:	102528494(BAK1)

BACU:

102999845

BMUS:

118904117(BAK1)

LVE:

103069848

OOR:	101281395(BAK1)

DLE:	111178690(BAK1)

PCAD:

102991092(BAK1)

PSIU:

116762061(BAK1)

NASI:

112414038(BAK1)

ECB:	100061755(BAK1)

EPZ:	103544222(BAK1)

EAI:	106834586(BAK1)

MYB:	102240268(BAK1)

MYD:	102764949(BAK1)

MMYO:

118679638(BAK1)

MLF:	102437326(BAK1)

PKL:	118705679(BAK1)

EFUS:

103303014(BAK1)

MNA:	107541604(BAK1)

DRO:	112302219(BAK1)

SHON:

118991499(BAK1)

AJM:	119041220(BAK1)

PDIC:

114494928(BAK1)

PHAS:

123816219(BAK1)

MMF:	118621850(BAK1)

PPAM:

129066993(BAK1)

HAI:	109392454(BAK1)

RFQ:	117020728(BAK1)

PALE:

102883540(BAK1)

PGIG:

120597665(BAK1)

PVP:	105301000 111728746

RAY:	107511968(BAK1)

MJV:	108402940(BAK1)

TOD:	119252348(BAK1)

SARA:

101538133(BAK1)

SETR:

125996343(BAK1)

LAV:	100669799(BAK1)

TMU:

101341201

ETF:	101656097(BAK1)

DNM:	101426878(BAK1)

MDO:	100027503(BAK1)

GAS:	123243961(BAK1)

SHR:	100916731(BAK1)

AFZ:

127561143

PCW:	110217311(BAK1)

TVP:	118857067(BAK1)

OAA:	114813317(BAK1)

GGA:	419912(BAK1)

PCOC:

116236928(BAK1)

MGP:	100544475(BAK1)

CJO:	107324870(BAK1)

TPAI:

128088157(BAK1)

LMUT:

125684299(BAK1)

NMEL:

110388215(BAK1)

APLA:

101789424(BAK1)

ACYG:

106046164(BAK1)

CATA:

118259537(BAK1)

AFUL:

116498863(BAK1)

TGU:	100221739(BAK1)

LSR:	110477161(BAK1)

SCAN:

103823354(BAK1)

PMOA:

120495913(BAK1)

OTC:	121347987(BAK1)

PRUF:

121354001(BAK1)

GFR:	102040914(BAK1)

FAB:	101810079(BAK1)

OMA:	130263807(BAK1)

PHI:	102107798(BAK1)

PMAJ:

107215027(BAK1)

CCAE:

111939620(BAK1)

CCW:	104692533(BAK1)

CBRC:

103625364(BAK1)

ETL:	114064072(BAK1)

ZAB:	102072025(BAK1)

ZLE:	135458227(BAK1)

ACHL:

103805898(BAK1)

SVG:	106851021(BAK1)

HRT:	120762948(BAK1)

FPG:	101924229(BAK1)

FCH:	102047828(BAK1)

CLV:	102098929(BAK1)

EGZ:	104125775(BAK1)

NNI:	104013218(BAK1)

PCRI:

104030708(BAK1)

PLET:

104626569(BAK1)

PCAO:

104044578(BAK1)

ACUN:

113489021(BAK1)

TALA:

104362610(BAK1)

PADL:

103919822(BAK1)

AFOR:

103893635(BAK1)

ACHC:

115335157(BAK1)

HALD:

104312285(BAK1)

HLE:	104842383(BAK1)

AGEN:

126052394

GCL:

127026190

CCRI:

104160186(BAK1)

CSTI:

104549715(BAK1)

CMAC:

104477907(BAK1)

MUI:	104538866(BAK1)

BREG:

104637035(BAK1)

FGA:	104078543(BAK1)

GSTE:

104262102(BAK1)

LDI:	104350856(BAK1)

MNB:	103768785(BAK1)

OHA:	104335697(BAK1)

NNT:	104411471(BAK1)

SHAB:

115602411(BAK1)

DPUB:

104305386(BAK1)

PGUU:

104463478

ACAR:

104528592(BAK1)

CPEA:

104397169(BAK1)

AVIT:

104275210(BAK1)

CVF:	104289375(BAK1)

RTD:	128900346(BAK1)

CUCA:

104067115(BAK1)

TEO:	104381383(BAK1)

BRHI:

104491325

AAM:	106483956(BAK1)

AROW:

112961412(BAK1)

NPD:	112959245(BAK1)

TGT:	104570762(BAK1)

DNE:	112990245(BAK1)

SCAM:

104142090(BAK1)

ASN:	102374149(BAK1)

AMJ:	102570499(BAK1)

CPOO:

109317800(BAK1)

GGN:	109295372(BAK1)

PSS:	102449586(BAK1)

CMY:	102946475(BAK1)

CCAY:

125625113(BAK1)

DCC:	119846335(BAK1)

CPIC:

101935419(BAK1)

TST:	117875863(BAK1)

CABI:

116818003(BAK1)

MRV:	120404933(BAK1)

ACS:	100564650(bak1)

ASAO:

132773710(BAK1)

PVT:	110080152(BAK1)

SUND:

121929548(BAK1)

PBI:	103053500(BAK1)

PMUR:

107287068(BAK1)

CTIG:

120298931(BAK1)

TSR:	106541202(BAK1)

PGUT:

117663987(BAK1)

APRI:

131194729(BAK1)

PTEX:

113446982 113447762

NSS:	113418757 113419000

VKO:	123030365(BAK1)

PMUA:

114599223(BAK1)

PRAF:

128416009(BAK1)

ZVI:	118088837(BAK1)

HCG:	128324835(BAK1)

GJA:	107117593(BAK1)

STOW:

125433736(BAK1)

EMC:	129330550(BAK1)

XLA:	734644(bak1.S)

XTR:	108645783(bak1)

NPR:	108787278(BAK1)

RTEM:

120927258(BAK1)

BBUF:

120995161(BAK1)

BGAR:

122932100(BAK1)

MUO:	115481830(BAK1)

GSH:	117347221(BAK1)

SFM:	108931251(bak1)

PKI:	111844757(bak1)

AANG:

118207640

LOC:	102683790(bak1)

PSPA:

121299910 121304731

ARUT:

117435272

PSEX:

120536453

LCM:	102345216(BAK1) 102364872

CMK:	103179069 103181832

RTP:	109911651 109917897

CPLA:

122559374 122563274

HOC:	132824737 132828432

LERI:

129706538 129708611

PMRN:

116956381(BAK1)

LRJ:	133360311 133360399

BFO:

118407532

BBEL:

109463044 109486941

SPU:	115917937 588418

LPIC:

APLC:

ARUN:

SKO:

DPTE:

HRO:	HELRODRAFT_79940

LGI:	LOTGIDRAFT_235302 LOTGIDRAFT_57281

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105336915 117691172 117692211

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

127851844 127851845 127851849

MAEA:

128238145

OBI:

106868686

OSN:	115219866 115232299

LJP:

135482226

LAK:	106156464 106181879

SMM:	Smp_095190 Smp_131280

SHX:	MS3_00003243(BAK1_1)

OVI:	T265_03054

LLON:

135487947

NVE:

5522335

EPA:	110241252 110244709

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100208613 100212122

HSY:	130655652 130655654

RES:	135682638 135687629

AQU:

100636521

» show all

Reference

PMID:15776018

Authors

Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ

Title

Proapoptotic BAX and BAK control multiple initiator caspases.

Journal

EMBO Rep 6:379-85 (2005)
DOI:10.1038/sj.embor.7400375

Sequence

[mmu:12018]

Reference

PMID:7715730

Authors

Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC

Title

Induction of apoptosis by the Bcl-2 homologue Bak.

Journal

Nature 374:733-6 (1995)
DOI:10.1038/374733a0

Sequence

[hsa:578]

All links

Ontology (4)   
   KEGG BRITE (3)   
   TC (1)   
Pathway (66)   
   KEGG PATHWAY (66)   
Gene (423)   
   KEGG GENES (362)   
   KEGG MGENES (19)   
   RefGene (34)   
   OC (8)   
Literature (2)   
   PubMed (2)   
All databases (495)   

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