| Entry |
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| Name |
[methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase;
methyltransferase 2 (ambiguous);
mtaA (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
methylated methanol-specific corrinoid protein:CoM methyltransferase
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| Reaction(IUBMB) |
a [methyl-Co(III) methanol-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methanol-specific corrinoid protein] [RN: R10000]
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| Reaction(KEGG) |
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| Substrate |
[methyl-Co(III) methanol-specific corrinoid protein];
CoM [CPD: C03576]
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| Product |
methyl-CoM [CPD: C03920];
[Co(I) methanol-specific corrinoid protein]
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| Comment |
The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro [5].
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| History |
EC 2.1.1.246 created 2012
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K14080 | [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
LeClerc GM, Grahame DA |
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| Title |
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Harms U, Thauer RK |
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| Title |
Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Sauer K, Thauer RK |
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| Title |
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction. |
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| Journal |
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| Reference |
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| Authors |
Sauer K, Harms U, Thauer RK |
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| Title |
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, properties and encoding genes of the corrinoid protein MT1. |
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| Journal |
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| Reference |
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| Authors |
Sauer K, Thauer RK |
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| Title |
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.246 |
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