KEGG   ORTHOLOGY: K14132Help
Entry
K14132                      KO                                     

Name
FTMPT1
Definition
tryprostatin B synthase [EC:2.5.1.106]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K14132  FTMPT1; tryprostatin B synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K14132  FTMPT1; tryprostatin B synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.106  tryprostatin B synthase
     K14132  FTMPT1; tryprostatin B synthase
Prenyltransferases [BR:ko01006]
 Compound prenylation
  Indole prenyltransferase
   K14132  FTMPT1; tryprostatin B synthase
BRITE hierarchy
Other DBs
RN: R10340
Genes
AFM: AFUA_8G00210
NFI: NFIA_093720
TaxonomyKoalaUniProt
Reference
  Authors
Grundmann A, Li SM
  Title
Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus.
  Journal
Microbiology 151:2199-207 (2005)
DOI:10.1099/mic.0.27962-0
  Sequence

KEGG   ENZYME: 2.5.1.106Help
Entry
EC 2.5.1.106                Enzyme                                 

Name
tryprostatin B synthase;
ftmPT1 (gene name);
brevianamide F prenyltransferase (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase
Reaction(IUBMB)
dimethylallyl diphosphate + brevianamide F = diphosphate + tryprostatin B [RN:R10340]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
brevianamide F [CPD:C20563]
Product
diphosphate [CPD:C00013];
tryprostatin B [CPD:C20512]
Comment
The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen.
History
EC 2.5.1.106 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K14132  tryprostatin B synthase
Genes
AFM: AFUA_8G00210
NFI: NFIA_093720
Taxonomy
Reference
1  [PMID:16000710]
  Authors
Grundmann A, Li SM
  Title
Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus.
  Journal
Microbiology 151:2199-207 (2005)
DOI:10.1099/mic.0.27962-0
  Sequence
Reference
2  [PMID:23090579]
  Authors
Wollinsky B, Ludwig L, Xie X, Li SM
  Title
Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1.
  Journal
Org Biomol Chem 10:9262-70 (2012)
DOI:10.1039/c2ob26149a
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.106
IUBMB Enzyme Nomenclature: 2.5.1.106
ExPASy - ENZYME nomenclature database: 2.5.1.106
BRENDA, the Enzyme Database: 2.5.1.106

KEGG   REACTION: R10340Help
Entry
R10340                      Reaction                               

Name
dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase
Definition
Dimethylallyl diphosphate + Brevianamide F <=> Diphosphate + Tryprostatin B
Equation
Reaction class
RC03129  C20512_C20563
Enzyme
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Orthology
K14132  tryprostatin B synthase [EC:2.5.1.106]
Other DBs
RHEA: 35942

DBGET integrated database retrieval system