KEGG   ORTHOLOGY: K14134Help
Entry
K14134                      KO                                     

Name
FTMPT2
Definition
12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase [EC:2.5.1.110]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K14134  FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K14134  FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.110  12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
     K14134  FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
Prenyltransferases [BR:ko01006]
 Compound prenylation
  Indole prenyltransferase
   K14134  FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
BRITE hierarchy
Other DBs
RN: R10457
Genes
AFM: AFUA_8G00250
NFI: NFIA_093760
TaxonomyKoalaUniProt
Reference
  Authors
Grundmann A, Kuznetsova T, Afiyatullov SSh, Li SM
  Title
FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B.
  Journal
Chembiochem 9:2059-63 (2008)
DOI:10.1002/cbic.200800240
  Sequence

KEGG   ENZYME: 2.5.1.110Help
Entry
EC 2.5.1.110                Enzyme                                 

Name
12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase;
ftmH (gene name);
FtmPT2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
Reaction(IUBMB)
dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B [RN:R10457]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
12alpha,13alpha-dihydroxyfumitremorgin C [CPD:C20605]
Product
diphosphate [CPD:C00013];
fumitremorgin B [CPD:C20630]
Comment
The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
History
EC 2.5.1.110 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K14134  12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
Genes
AFM: AFUA_8G00250
NFI: NFIA_093760
Taxonomy
Reference
1  [PMID:18683158]
  Authors
Grundmann A, Kuznetsova T, Afiyatullov SSh, Li SM
  Title
FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B.
  Journal
Chembiochem 9:2059-63 (2008)
DOI:10.1002/cbic.200800240
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.110
IUBMB Enzyme Nomenclature: 2.5.1.110
ExPASy - ENZYME nomenclature database: 2.5.1.110
BRENDA, the Enzyme Database: 2.5.1.110

KEGG   REACTION: R10457Help
Entry
R10457                      Reaction                               

Name
dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
Definition
Dimethylallyl diphosphate + 12alpha,13alpha-Dihydroxyfumitremorgin C <=> Diphosphate + Fumitremorgin B
Equation
Reaction class
RC00829  C20605_C20630
Enzyme
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Orthology
K14134  12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase [EC:2.5.1.110]
Other DBs
RHEA: 35974

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