KEGG   ORTHOLOGY: K14135Help
Entry
K14135                      KO                                     

Name
FGAPT1
Definition
fumigaclavine A dimethylallyltransferase [EC:2.5.1.100]
Pathway
ko00901  Indole alkaloid biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K14135  FGAPT1; fumigaclavine A dimethylallyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K14135  FGAPT1; fumigaclavine A dimethylallyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.100  fumigaclavine A dimethylallyltransferase
     K14135  FGAPT1; fumigaclavine A dimethylallyltransferase
Prenyltransferases [BR:ko01006]
 Compound prenylation
  Indole prenyltransferase
   K14135  FGAPT1; fumigaclavine A dimethylallyltransferase
BRITE hierarchy
Other DBs
RN: R10201
Genes
AFM: AFUA_2G17990
TaxonomyKoalaUniProt
Reference
  Authors
Unsold IA, Li SM
  Title
Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of fumigaclavine C synthase FGAPT1.
  Journal
Chembiochem 7:158-64 (2006)
DOI:10.1002/cbic.200500318
  Sequence

KEGG   ENZYME: 2.5.1.100Help
Entry
EC 2.5.1.100                Enzyme                                 

Name
fumigaclavine A dimethylallyltransferase;
FgaPT1
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:fumigaclavine A dimethylallyltransferase
Reaction(IUBMB)
fumigaclavine A + dimethylallyl diphosphate = fumigaclavine C + diphosphate [RN:R10201]
Reaction(KEGG)
Substrate
fumigaclavine A [CPD:C20436];
dimethylallyl diphosphate [CPD:C00235]
Product
fumigaclavine C [CPD:C20438];
diphosphate [CPD:C00013]
Comment
Fumigaclavine C is an ergot alkaloid produced by some fungi of the Trichocomaceae family. Activity does not require any metal ions.
History
EC 2.5.1.100 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K14135  fumigaclavine A dimethylallyltransferase
Genes
AFM: AFUA_2G17990
Taxonomy
Reference
1  [PMID:16397874]
  Authors
Unsold IA, Li SM
  Title
Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of fumigaclavine C synthase FGAPT1.
  Journal
Chembiochem 7:158-64 (2006)
DOI:10.1002/cbic.200500318
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.100
IUBMB Enzyme Nomenclature: 2.5.1.100
ExPASy - ENZYME nomenclature database: 2.5.1.100
BRENDA, the Enzyme Database: 2.5.1.100

KEGG   REACTION: R10201Help
Entry
R10201                      Reaction                               

Name
dimethylallyl-diphosphate:fumigaclavine A dimethylallyltransferase
Definition
Fumigaclavine A + Dimethylallyl diphosphate <=> Fumigaclavine C + Diphosphate
Equation
Reaction class
RC03081  C20436_C20438
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K14135  fumigaclavine A dimethylallyltransferase [EC:2.5.1.100]
Other DBs
RHEA: 34266

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