KEGG   ORTHOLOGY: K14244Help
Entry
K14244                      KO                                     

Name
oxyD
Definition
amidotransferase [EC:6.3.5.-]
Pathway
ko00253  Tetracycline biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00253 Tetracycline biosynthesis
    K14244  oxyD; amidotransferase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.-  
     K14244  oxyD; amidotransferase
BRITE hierarchy
Other DBs
RN: R09195 R11515
Genes
AG: AAZ78328(oxyD)
TaxonomyKoalaUniProt
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419

KEGG   REACTION: R11515Help
Entry
R11515                      Reaction                               

Name
malonyl-[acyl-carrier protein]:L-glutamine amido-ligase (AMP-forming)
Definition
ATP + Malonyl-[acyl-carrier protein] + L-Glutamine + H2O <=> AMP + Diphosphate + Malonamoyl-[acyl-carrier protein] + L-Glutamate
Equation
Comment
The substrate of OxyD can be either malonyl-CoA (see R09195) or malonyl-ACP.
Reaction class
RC00010  C00025_C00064  C01209_C21430
Enzyme
6.3.5.-
Pathway
rn00253  Tetracycline biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K14244  amidotransferase [EC:6.3.5.-]

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