KEGG   ORTHOLOGY: K14249
Entry
K14249            Tight     KO                                     
Symbol
oxyK
Name
bifunctional cyclase/aromatase [EC:4.2.1.-]
Pathway
map00253  Tetracycline biosynthesis
map01056  Biosynthesis of type II polyketide backbone
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Reaction
R09187  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K14249  oxyK; bifunctional cyclase/aromatase
   00253 Tetracycline biosynthesis
    K14249  oxyK; bifunctional cyclase/aromatase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14249  oxyK; bifunctional cyclase/aromatase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Nonaketide PKS
     K14249  oxyK; bifunctional cyclase/aromatase
Genes
SRIM: CP984_02420
AG: AAZ78334(oxyK)
Reference
PMID:16597959
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
[ag:AAZ78334]
Reference
PMID:20522541
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:10551844
  Authors
Petkovic H, Thamchaipenet A, Zhou LH, Hranueli D, Raspor P, Waterman PG, Hunter IS
  Title
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.
  Journal
J Biol Chem 274:32829-34 (1999)
DOI:10.1016/S0021-9258(17)46583-5

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG GENES (2)   
Literature (3)   
   PubMed (3)   
All databases (18)   

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