KEGG   ORTHOLOGY: K14249Help
Entry
K14249                      KO                                     

Name
oxyK
Definition
bifunctional cyclase/aromatase [EC:4.2.1.-]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K14249  oxyK; bifunctional cyclase/aromatase
   00253 Tetracycline biosynthesis
    K14249  oxyK; bifunctional cyclase/aromatase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-  
     K14249  oxyK; bifunctional cyclase/aromatase
BRITE hierarchy
Other DBs
RN: R09187
Genes
AG: AAZ78334(oxyK)
TaxonomyKoalaUniProt
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
  Authors
Petkovic H, Thamchaipenet A, Zhou LH, Hranueli D, Raspor P, Waterman PG, Hunter IS
  Title
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.
  Journal
J Biol Chem 274:32829-34 (1999)

KEGG   REACTION: R09187Help
Entry
R09187                      Reaction                               

Definition
C-9 Reduced nonaketamide <=> Nonaketamide monocyclic intermediate + 2 H2O
Equation
Comment
bifunctional cyclase/aromatase, OxyK (otcD1)
Reaction class
RC02458  C12442_C18293
Enzyme
4.2.1.-
Pathway
rn00253  Tetracycline biosynthesis
rn01056  Biosynthesis of type II polyketide backbone
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Orthology
K14249  bifunctional cyclase/aromatase [EC:4.2.1.-]

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