KEGG   ORTHOLOGY: K14250Help
Entry
K14250                      KO                                     

Name
oxyN, snoaM, dpsY, aknW, mtmY
Definition
cyclase
Pathway
ko00253  Tetracycline biosynthesis
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
   00253 Tetracycline biosynthesis
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
BRITE hierarchy
Other DBs
RN: R09188 R09325 R09326 R09350
Genes
SFA: Sfla_5330
SBH: SBI_06843
SHY: SHJG_1191
SHO: SHJGH_1026
STRP: F750_1293
SCI: B446_13310
SGS: AVL59_46195
KAL: KALB_7821
LED: BBK82_02440
MAU: Micau_4023
MIL: ML5_4398
AG: AAC38443(dpsY) AAF01818(snoaM) AAF73459(aknW) AAZ78337(oxyN) CAK50782(mtmY)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:16597959 (oxyN)
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
  Authors
Zhang W, Watanabe K, Wang CC, Tang Y
  Title
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.
  Journal
J Biol Chem 282:25717-25 (2007)
DOI:10.1074/jbc.M703437200
Reference
PMID:11683270 (snoaM)
  Authors
Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K
  Title
The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.
  Journal
Mol Genet Genomics 266:276-88 (2001)
DOI:10.1007/s004380100554
  Sequence
Reference
PMID:9573189 (dpsY)
  Authors
Lomovskaya N, Doi-Katayama Y, Filippini S, Nastro C, Fonstein L, Gallo M, Colombo AL, Hutchinson CR
  Title
The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.
  Journal
J Bacteriol 180:2379-86 (1998)
  Sequence
Reference
PMID:10102355 (mtmY)
  Authors
Prado L, Lombo F, Brana AF, Mendez C, Rohr J, Salas JA
  Title
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.
  Journal
Mol Gen Genet 261:216-25 (1999)
DOI:10.1007/s004380050960
  Sequence

KEGG   REACTION: R09325Help
Entry
R09325                      Reaction                               

Definition
7,9,12-Decaketide intermediate 3 <=> Deoxynogalonate
Equation
Comment
cyclase, snoaM
Reaction class
RC02512  C18332_C18629
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Orthology
K14250  cyclase

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