KEGG   ORTHOLOGY: K14251
Entry
K14251                      KO                                     

Name
oxyF
Definition
C-methyltransferase [EC:2.1.1.-]
Pathway
ko00253  Tetracycline biosynthesis
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14251  oxyF; C-methyltransferase
   00253 Tetracycline biosynthesis
    K14251  oxyF; C-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-  
     K14251  oxyF; C-methyltransferase
Other DBs
RN: R09189
Genes
LEZ: GLE_3646
LHA: LHA_2056
LCD: clem_05020(tcmN)
LSH: CAB17_01660
LGT: E4T54_11355
LWA: SAMEA4504053_1225(tcmN)
BPM: BURPS1710b_A1647
BPSE: BDL_6021
BPSM: BBQ_3555
BPSU: BBN_6044
BPSD: BBX_5190
BPK: BBK_5324
BPSA: BBU_3441
BPSO: X996_5000
BUT: X994_4548
BTD: BTI_4656
BOK: DM82_3836
BOC: BG90_4207
BUL: BW21_4181
SCO: SCO7452(SC5C11.09c)
SFA: Sfla_6024
SBH: SBI_02773
SVE: SVEN_6791
STRP: F750_0544
SALU: DC74_1539
SALL: SAZ_08220
SLD: T261_1185
STRM: M444_28745
SPRI: SPRI_1902
SRW: TUE45_01299(tcmN_1) TUE45_02733(tcmN_2)
SLE: sle_64170(sle_64170)
STRD: NI25_35540
SMAL: SMALA_6137
SFK: KY5_6672c
SGE: DWG14_04084(mmcR)
SRJ: SRO_4045
KSK: KSE_72520
AORI: SD37_34170
ACTN: L083_2485
CAI: Caci_4546
SGN: SGRA_1249
AG: AAZ78330(oxyF)
 » show all
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
  Authors
Zhang W, Watanabe K, Wang CC, Tang Y
  Title
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.
  Journal
J Biol Chem 282:25717-25 (2007)
DOI:10.1074/jbc.M703437200

KEGG   REACTION: R09189
Entry
R09189                      Reaction                               

Name
S-adenosyl-L-methionine:pretetramid C-methyltransferase
Definition
S-Adenosyl-L-methionine + Pretetramid <=> S-Adenosyl-L-homocysteine + 6-Methylpretetramide
Equation
Reaction class
RC00003  C00019_C00021
RC01662  C06629_C18295
Enzyme
2.1.1.-
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Orthology
K14251  C-methyltransferase [EC:2.1.1.-]

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