KEGG ORTHOLOGY: K14317

ORTHOLOGY: K14317

Entry

K14317                      KO

Symbol

NUP214, CAN

Name

nuclear pore complex protein Nup214

Pathway

map03013

Nucleocytoplasmic transport

map05014

Amyotrophic lateral sclerosis

Disease

H00003

Acute myeloid leukemia

H02536

Infection-induced acute encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09122 Translation
   03013 Nucleocytoplasmic transport
    K14317  NUP214, CAN; nuclear pore complex protein Nup214
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K14317  NUP214, CAN; nuclear pore complex protein Nup214
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K14317  NUP214, CAN; nuclear pore complex protein Nup214
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    Nuclear pore complex
     K14317  NUP214, CAN; nuclear pore complex protein Nup214

Other DBs

GO:	0005487 0017056

TC:

1.I.1.1

Genes

HSA:	8021(NUP214)

PTR:	464807(NUP214)

PPS:	100967814(NUP214)

GGO:	101139346(NUP214)

PON:	100442200(NUP214)

NLE:	100603488(NUP214)

HMH:	116475778(NUP214)

MCC:	722421(NUP214)

MCF:	101865169(NUP214)

MTHB:

126936876

MNI:	105464101(NUP214)

CSAB:

103239737(NUP214)

CATY:

105576168(NUP214)

PANU:

101004751(NUP214)

TGE:	112607907(NUP214)

MLEU:

105532837(NUP214)

RRO:	104660556(NUP214)

RBB:	108513925(NUP214)

TFN:	117073380(NUP214)

PTEH:

111545832(NUP214)

CANG:

105504009(NUP214)

CJC:	100400586(NUP214)

SBQ:	101048784(NUP214)

CIMI:

108282987(NUP214)

CSYR:

103259781(NUP214)

MMUR:

105862785(NUP214)

LCAT:

123646587(NUP214)

PCOQ:

105806645(NUP214)

OGA:	100966801(NUP214)

MMU:	227720(Nup214)

MCAL:

110311834(Nup214)

MPAH:

110318458(Nup214)

RNO:	296634(Nup214)

MCOC:

116089983(Nup214)

ANU:	117703376(Nup214)

MUN:	110559464(Nup214)

CGE:	100752558(Nup214)

MAUA:

101827647(Nup214)

PROB:

127222753(Nup214)

PLEU:

114703790(Nup214)

MORG:

121462713(Nup214)

MFOT:

126509445

AAMP:

119818667(Nup214)

NGI:	103727678(Nup214)

HGL:	101722062(Nup214)

CPOC:

100729364(Nup214)

CCAN:

109687633

DORD:

105989330(Nup214)

DSP:	122108996(Nup214)

PLOP:

125350481(Nup214)

NCAR:

124964284

MMMA:

107151991(Nup214)

OCU:

100355984

OPI:	101523386(NUP214)

TUP:	102494195(NUP214)

GVR:	103599111(NUP214)

CFA:	608534(NUP214)

CLUD:

112677343(NUP214)

VVP:	112927990(NUP214)

VLG:	121473062(NUP214)

NPO:	129503992(NUP214)

AML:

100466970

UMR:	103670410(NUP214)

UAH:	113266528(NUP214)

UAR:	123775756(NUP214)

ELK:

111145520

LLV:

125082895

MPUF:

101688383(NUP214)

MNP:	132024320(NUP214)

MLK:	131812545(NUP214)

NVS:	122917154(NUP214)

ORO:	101368862(NUP214)

EJU:	114198880(NUP214)

ZCA:	113934269(NUP214)

MLX:	118017576(NUP214)

NSU:	110581451(NUP214)

FCA:	101099000(NUP214)

PYU:	121035120(NUP214)

PCOO:

112849811(NUP214)

PBG:	122474659(NUP214)

PVIV:

125149830(NUP214)

LRUF:

124525658

PTG:	102961479(NUP214)

PPAD:

109250009(NUP214)

PUC:

125922661

AJU:

106985337

HHV:	120230096(NUP214)

BTA:	784219(NUP214)

BOM:	102288310(NUP214)

BIU:	109566557(NUP214)

BBUB:

102404152(NUP214)

BBIS:

105000785(NUP214)

CHX:	102185190(NUP214)

OAS:	101114502(NUP214)

BTAX:

128055398(NUP214)

ODA:	120852107(NUP214)

CCAD:

122442283(NUP214)

MBEZ:

129539033(NUP214)

SSC:	100155564(NUP214)

CFR:	102520268(NUP214)

CBAI:

105069702(NUP214)

CDK:	105085163(NUP214)

VPC:	102527807(NUP214)

BACU:

103005621(NUP214)

BMUS:

118896628(NUP214)

LVE:	103070544(NUP214)

OOR:	101279973(NUP214)

DLE:	111177109(NUP214)

PCAD:

102989932(NUP214)

PSIU:

116755283(NUP214)

NASI:

112411206(NUP214)

ECB:	100069634(NUP214) 111767496

EPZ:	103561036(NUP214)

EAI:	106845387(NUP214)

MYB:	102251677(NUP214)

MYD:	102762682(NUP214)

MMYO:

118666945(NUP214)

MLF:	102434367(NUP214)

PKL:	118708861(NUP214)

EFUS:

103296012(NUP214)

MNA:	107524644(NUP214)

DRO:	112306236(NUP214)

SHON:

118980065(NUP214)

AJM:	119059007(NUP214)

PDIC:

114499806(NUP214)

PHAS:

123823300(NUP214)

MMF:	118629494(NUP214)

PPAM:

129079200(NUP214)

HAI:	109380707(NUP214)

RFQ:	117031992(NUP214)

PALE:

102896624(NUP214)

PGIG:

120602715(NUP214)

PVP:	105298687(NUP214)

RAY:	107504554(NUP214)

MJV:	108408193(NUP214)

TOD:	119231218(NUP214)

SARA:

101537748(NUP214)

SETR:

126008538(NUP214)

LAV:	100670029(NUP214)

TMU:

101342921

ETF:	101659361(NUP214)

DNM:	101426328(NUP214)

MDO:	100013666(NUP214)

GAS:	123237221(NUP214)

SHR:	100913204(NUP214)

AFZ:

127550909

PCW:	110198901(NUP214)

OAA:	100075403(NUP214)

GGA:	427760(NUP214)

PCOC:

116234256(NUP214)

MGP:	100551176(NUP214)

CJO:	107321812(NUP214)

TPAI:

128073886(NUP214)

LMUT:

125702473(NUP214)

NMEL:

110406738(NUP214)

APLA:

101794724(NUP214)

ACYG:

106044074(NUP214)

CATA:

118252168(NUP214)

AFUL:

116496895(NUP214)

TGU:	100232127(NUP214)

LSR:	110477596(NUP214)

SCAN:

103818993(NUP214)

PMOA:

120507448(NUP214)

OTC:	121336968(NUP214)

PRUF:

121357517(NUP214)

GFR:	102031442(NUP214)

FAB:	101817884(NUP214)

OMA:	130260209(NUP214)

PHI:	102100368(NUP214)

PMAJ:

107212140(NUP214)

CCAE:

111937008(NUP214)

CCW:	104688477(NUP214)

CBRC:

103623263(NUP214)

ETL:	114073808(NUP214)

ZAB:	102065615(NUP214)

ACHL:

103804805(NUP214)

SVG:	106851352(NUP214)

MMEA:

130581775(NUP214)

HRT:	120761728(NUP214)

FPG:	101919400(NUP214)

FCH:	102058677(NUP214)

CLV:	102091705(NUP214)

EGZ:	104129837(NUP214)

NNI:	104023272(NUP214)

PCRI:

104030820(NUP214)

PLET:

104622911(NUP214)

EHS:	104515354(NUP214)

PCAO:

104048097(NUP214)

ACUN:

113486598(NUP214)

TALA:

104367624(NUP214)

PADL:

103915365(NUP214)

AFOR:

103905380(NUP214)

ACHC:

115335265(NUP214)

HALD:

104317851(NUP214)

HLE:	104833898(NUP214)

AGEN:

126052054

GCL:

127023612

CCRI:

104159380(NUP214)

CSTI:

104562021(NUP214)

MUI:	104539338(NUP214)

BREG:

104641275(NUP214)

FGA:	104083216(NUP214)

GSTE:

104257270(NUP214)

LDI:	104346285(NUP214)

MNB:	103768161(NUP214)

OHA:	104329723(NUP214)

NNT:	104402982(NUP214)

SHAB:

115617006(NUP214)

DPUB:

104296457(NUP214)

PGUU:

104461573(NUP214)

ACAR:

104524682(NUP214)

CPEA:

104389924(NUP214)

AVIT:

104278041(NUP214)

CVF:	104292873(NUP214)

RTD:	128917669(NUP214)

CUCA:

104066922(NUP214)

TEO:	104373021(NUP214)

BRHI:

104494716(NUP214)

AAM:	106490322(NUP214)

AROW:

112964281(NUP214)

NPD:	112955880(NUP214)

TGT:	104566166(NUP214)

DNE:	112984163(NUP214)

SCAM:

104138306(NUP214)

ASN:

102375132

AMJ:	102568058(NUP214)

CPOO:

109313950(NUP214)

GGN:	109292972(NUP214)

PSS:	102462032(NUP214)

CMY:	102943281(NUP214)

CCAY:

125623381(NUP214)

DCC:	119844098(NUP214)

CPIC:

101933880(NUP214)

TST:	117889510(NUP214)

CABI:

116835141(NUP214)

MRV:	120386767(NUP214)

ACS:	103282085(nup214)

ASAO:

132763568(NUP214)

PVT:	110079652(NUP214)

SUND:

121936579(NUP214)

PBI:	103064502(NUP214)

PMUR:

107295981

CTIG:

120308720(NUP214)

TSR:	106550909(NUP214)

PGUT:

117671276(NUP214)

APRI:

131186257(NUP214)

PTEX:

113443999(NUP214)

NSS:	113424124(NUP214)

VKO:	123028273(NUP214)

PMUA:

114588803(NUP214)

PRAF:

128406209(NUP214)

ZVI:	118083797(NUP214)

HCG:	128338925(NUP214)

GJA:	107121346(NUP214)

STOW:

125441542(NUP214)

EMC:	129342287(NUP214)

XLA:	379353(nup214.L)

XTR:	100145463(nup214)

NPR:	108792062(NUP214)

RTEM:

120940296(NUP214)

BBUF:

121009170(NUP214)

BGAR:

122919938(NUP214) 122946160

MUO:	115473129(NUP214)

GSH:	117367843(NUP214)

DRE:	100529857(nup214)

SRX:	107741499 107745626

SANH:

107674911 107705012

SGH:	107562326 107597939

CCAR:

109079925

CAUA:

113068070 113086616

CGIB:

127957233 127992578

PTET:

122345403(nup214)

LROH:

127165433(nup214)

OMC:	131540052(nup214)

PPRM:

120471945(nup214)

RKG:	130078272(nup214)

MAMB:

125267866(nup214)

CIDE:

127513142

MASI:

127422635 127435432

TROS:

130564992(nup214)

TDW:	130419934(nup214)

MANU:

129440767(nup214)

IPU:

108260123

IFU:	128603853(nup214)

PHYP:

113531423(nup214)

SMEO:

124379394(nup214)

TFD:	113650894(nup214)

TVC:	132841355(nup214)

AMEX:

103044192(nup214)

CMAO:

118814839(nup214)

EEE:	113587317(nup214)

CHAR:

105906400(nup214)

TRU:	101071502(nup214)

TFS:	130516817(nup214)

TNG:	GSTEN00011738G001

LCO:	104936212(nup214)

TBEN:

117476486(nup214)

CGOB:

115016562(nup214)

PGEO:

117455948(nup214)

GACU:

117537980(nup214)

EMAC:

134868692(nup214)

ELY:	117269911(nup214)

EFO:	125905716(nup214)

PLEP:

121959538(nup214)

SLUC:

116062839(nup214)

ECRA:

117959372(nup214)

ESP:	116704423(nup214)

PFLV:

114570703(nup214)

GAT:	120831926(nup214)

PPUG:

119226780(nup214)

AFB:	129102344(nup214)

CLUM:

117740220(nup214)

PSWI:

130205813(nup214)

MSAM:

119914260(nup214)

SCHU:

122865111(nup214)

CUD:	121525244(nup214)

ALAT:

119029668(nup214)

MZE:	101487745(nup214)

ONL:	100695952(nup214)

OAU:	116331715(nup214)

OLA:	101170858(nup214)

OML:	112162803(nup214)

CSAI:

133456511 133463173

XMA:	102217374(nup214)

XCO:	114149447(nup214)

XHE:	116724212(nup214)

PRET:

103473846(nup214)

PFOR:

103142767(nup214)

PLAI:

106961639(nup214)

PMEI:

106925446(nup214)

GAF:	122819653(nup214)

PPRL:

129366308(nup214)

CVG:	107096106(nup214)

CTUL:

119789822(nup214)

GMU:	124872335(nup214)

NFU:	107374666(nup214)

KMR:	108231035(nup214)

ALIM:

106518210(nup214)

NWH:	119424978(nup214)

AOCE:

111577472(nup214)

MCEP:

124996766(nup214)

CSEM:

103390209(nup214)

POV:	109626228(nup214)

SSEN:

122758293

HHIP:

117771780(nup214)

HSP:	118097995(nup214)

SMAU:

118284564

LCF:

108874004

SDU:	111238503(nup214)

SLAL:

111664781(nup214)

XGL:	120806321(nup214)

HCQ:	109528146(nup214)

SSCV:

125979605

SBIA:

133491129(nup214)

PEE:	133413981(nup214)

PTAO:

133489985(nup214)

BPEC:

110160464(nup214)

MALB:

109960617(nup214)

BSPL:

114867354(nup214)

SJO:	128380465(nup214)

SASA:

106563260 106565702

STRU:

115159533 115204100

OTW:	112219335(nup214) 112233457

OMY:	110509345 110523615(nup214)

OGO:	124006739 124047679

ONE:	115101190 115117560

OKI:	109867993 109873607

OKE:	118384861 118387553

SALP:

111961585 111964530

SNH:	120020999 120025721(nup214)

CCLU:

121542211 121582479

ELS:	105015113(nup214)

SFM:	108927184(nup214)

PKI:	111847452(nup214)

AANG:

118213050(nup214)

LOC:	102683889(nup214)

PSPA:

121309673(nup214)

ARUT:

117396887 117422209

PSEX:

120536051(nup214)

LCM:	102356271(NUP214)

CMK:	103183103(nup214)

PMRN:

116953275(NUP214)

LRJ:	133354688(NUP214)

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG3820(Nup214)

DER:

6547375

DSI:	Dsimw501_GD25096(Dsim_GD25096)

DYA:	Dyak_GE11622

DSR:

110177392

DPO:

4805560

DPE:

6603162

DMN:	108158604 117194134

DWI:

6639672

DGR:

6561008

DMO:	Dmoj_GI18357

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

MDE:

SCAC:

LCQ:

LSQ:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ009141

CPII:

120427825

CNS:

116343921

BCOO:

119072911

AME:	412464 726354

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:	124953973 124956572

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209269A

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM479060

FOC:

TPAL:

ZNE:

CSEC:

FCD:

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

PTEP:

CEL:	CELE_C03D6.4(npp-14)

CBR:	CBG_03763(Cbr-npp-14)

CRQ:	GCK72_000564

NAI:	NECAME_15714

LOA:	LOAG_00114

TSP:

PCAN:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

OBI:

OSN:

LAK:

SMM:	Smp_124220

SHX:	MS3_00010048(NTMT1_1)

OVI:	T265_11837

EGL:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

AQU:

ATH:	AT1G55540(LNO1)

ALY:

9330571

CRB:

17898202

CSAT:

104744174 104758833 104778424

EUS:	EUTSA_v10011181mg

BRP:

103832578

BNA:	106360365 106360366

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10014017mg

PVY:	116105735 116128759

MINC:

123225010

TCC:

18589558

GRA:

105790920

GHI:	107952716 107954716

GAB:

HSYR:

DZI:

EGR:

GMX:	100794048 100806517

GSJ:	114394444 114416850

PVU:	PHAVU_007G078700g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj5g3v0612080.1(Lj5g3v0612080.1)

ADU:

107487091

AIP:

107646487

AHF:	112720306 112789726

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:	111990952 112015362

QLO:	115976917 115976922

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107802780 107819522

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

BVG:

SOE:

CQI:	110720890 110723919

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:	109736058 109746473 109753048

TDC:	119353161 119353230 119360535 119362354

TAES:

123043644 123051428 123051435 123051518 123187382

TUA:

125535621

LPER:

127331456

LRD:	124673245 124673783

SBI:	8074468 8085294

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

NCOL:

ATR:

SMO:	SELMODRAFT_443776

PPP:

112290479

CSL:	COCSUDRAFT_63339

CVR:	CHLNCDRAFT_52628

OLU:	OSTLU_15396

OTA:	OT_ostta05g02050

BPG:	Bathy03g02570

MIS:	MICPUN_100470

MPP:	MICPUCDRAFT_46822(JGI:MicpuC2_46822)

CCP:	CHC_T00005551001

MBR:	MONBRDRAFT_30860

DFA:

DFA_11186

ACAN:

ACA1_082150

» show all

Reference

PMID:16675447

Authors

Bernad R, Engelsma D, Sanderson H, Pickersgill H, Fornerod M

Title

Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export.

Journal

J Biol Chem 281:19378-86 (2006)
DOI:10.1074/jbc.M512585200

Sequence

[hsa:8021]

Reference

PMID:1549122

Authors

von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G

Title

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

Journal

Mol Cell Biol 12:1687-97 (1992)
DOI:10.1128/mcb.12.4.1687

Sequence

[hsa:8021]

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Ontology (5)   
   KEGG BRITE (2)   
   GO (2)   
   TC (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (2351)   
   KEGG GENES (750)   
   KEGG MGENES (637)   
   RefGene (937)   
   OC (27)   
Literature (2)   
   PubMed (2)   
All databases (2364)   

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