KEGG   ORTHOLOGY: K14371
Entry
K14371                      KO                                     

Name
aveA
Definition
type I polyketide synthase AVES
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14371  aveA; type I polyketide synthase AVES
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14371  aveA; type I polyketide synthase AVES
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14371  aveA; type I polyketide synthase AVES
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Avermectin PKS
     K14371  aveA; type I polyketide synthase AVES
Other DBs
RN: R06480 R06481 R06482 R06483
Genes
SMA: SAVERM_938(aveA1) SAVERM_939(aveA2) SAVERM_942(aveA3) SAVERM_943(aveA4)
Reference
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
  Authors
Ikeda H, Nonomiya T, Omura S
  Title
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.
  Journal
J Ind Microbiol Biotechnol 27:170-6 (2001)
DOI:10.1038/sj.jim.7000092

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (19)   
   KEGG REACTION (4)   
   KEGG RCLASS (15)   
Gene (5)   
   KEGG GENES (4)   
   OC (1)   
Protein sequence (4)   
   UniProt (4)   
Literature (2)   
   PubMed (2)   
All databases (41)   

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KEGG   REACTION: R06481
Entry
R06481                      Reaction                               

Definition
2-Methylbutanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
Equation
C01033 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11977 + 12 C00011 + 13 C00010 + 6 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C01033  C00010_C02557
RC02913  C01033_C11977
RC02915  C02557_C11977
RC02920  C02557_C11977
RC02921  C02557_C11977
RC02922  C02557_C11977
RC02924  C00083_C11977
RC02925  C00083_C11977
RC02926  C00083_C11977
RC02927  C00083_C11977
RC02928  C00083_C11977
RC02929  C00083_C11977
RC02930  C00083_C11977
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14371  type I polyketide synthase AVES

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (14)   
   KEGG RCLASS (14)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
All databases (37)   

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