KEGG   ORTHOLOGY: K14371Help
Entry
K14371                      KO                                     

Name
aveA
Definition
type I polyketide synthase AVES
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14371  aveA; type I polyketide synthase AVES
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14371  aveA; type I polyketide synthase AVES
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14371  aveA; type I polyketide synthase AVES
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Avermectin PKS
     K14371  aveA; type I polyketide synthase AVES
BRITE hierarchy
Other DBs
RN: R06480 R06481 R06482 R06483
Genes
SMA: SAVERM_938(aveA1) SAVERM_939(aveA2) SAVERM_942(aveA3) SAVERM_943(aveA4)
TaxonomyKoalaUniProt
Reference
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
  Authors
Ikeda H, Nonomiya T, Omura S
  Title
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.
  Journal
J Ind Microbiol Biotechnol 27:170-6 (2001)
DOI:10.1038/sj.jim.7000092

KEGG   REACTION: R06481Help
Entry
R06481                      Reaction                               

Definition
2-Methylbutanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
Equation
C01033 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11977 + 12 C00011 + 13 C00010 + 6 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C01033  C00010_C02557
RC02913  C01033_C11977
RC02915  C02557_C11977
RC02920  C02557_C11977
RC02921  C02557_C11977
RC02922  C02557_C11977
RC02924  C00083_C11977
RC02925  C00083_C11977
RC02926  C00083_C11977
RC02927  C00083_C11977
RC02928  C00083_C11977
RC02929  C00083_C11977
RC02930  C00083_C11977
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14371  type I polyketide synthase AVES

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