KEGG   ORTHOLOGY: K14372Help
Entry
K14372                      KO                                     

Name
aveE, CYP171A
Definition
cytochrome P450 hydroxylase [EC:1.14.-.-]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
   00199 Cytochrome P450
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-  
     K14372  aveE, CYP171A; cytochrome P450 hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K14372  aveE, CYP171A; cytochrome P450 hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP171 family
   K14372  aveE, CYP171A; cytochrome P450 hydroxylase
BRITE hierarchy
Other DBs
RN: R06465 R06467 R06468 R06470
COG: COG2124
Genes
SMA: SAVERM_941(aveE)
TaxonomyKoalaUniProt
Reference
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence

KEGG   REACTION: R06470Help
Entry
R06470                      Reaction                               

Definition
6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1b'' aglycone + NADP+ + H2O
Equation
Comment
cytochrome P450 hydroxylase,AveE
Reaction class
RC00001  C00005_C00006
RC01527  C11961_C11962
Enzyme
1.14.-.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14372  cytochrome P450 hydroxylase [EC:1.14.-.-]

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