KEGG   ORTHOLOGY: K14373
Entry
K14373            Tight     KO                                     
Symbol
aveF
Name
C-5 ketoreductase
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06472  
R06473  
R06474  
R06475  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14373  aveF; C-5 ketoreductase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14373  aveF; C-5 ketoreductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14373  aveF; C-5 ketoreductase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Ketoreductase
   K14373  aveF; C-5 ketoreductase
Genes
SMA: SAVERM_936(aveF)
Reference
PMID:11851473
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
PMID:10449723
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
[sma:SAVERM_936]

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (5)   
   KEGG REACTION (4)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG GENES (1)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (20)   

Download RDF
DBGET integrated database retrieval system