KEGG   ORTHOLOGY: K14373Help
Entry
K14373                      KO                                     

Name
aveF
Definition
C-5 ketoreductase
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14373  aveF; C-5 ketoreductase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14373  aveF; C-5 ketoreductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14373  aveF; C-5 ketoreductase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Ketoreductase
   K14373  aveF; C-5 ketoreductase
BRITE hierarchy
Other DBs
RN: R06472 R06473 R06474 R06475
Genes
SMA: SAVERM_936(aveF)
TaxonomyKoalaUniProt
Reference
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509

KEGG   REACTION: R06475Help
Entry
R06475                      Reaction                               

Definition
5-Oxoavermectin ''1b'' aglycone + NADPH + H+ <=> Avermectin B1b aglycone + NADP+
Equation
Comment
C-5 ketoreductase,AveF
Reaction class
RC00001  C00005_C00006
RC01528  C11962_C11963
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14373  C-5 ketoreductase

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