KEGG   ORTHOLOGY: K14374Help
Entry
K14374                      KO                                     

Name
aveD
Definition
avermectin B 5-O-methyltransferase [EC:2.1.1.-]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14374  aveD; avermectin B 5-O-methyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14374  aveD; avermectin B 5-O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14374  aveD; avermectin B 5-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-  
     K14374  aveD; avermectin B 5-O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K14374  aveD; avermectin B 5-O-methyltransferase
BRITE hierarchy
Other DBs
RN: R06476 R06477 R06478 R06479
Genes
SMA: SAVERM_937(aveD)
TaxonomyKoalaUniProt
Reference
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
PMID:9469930
  Authors
Ikeda H, Wang LR, Ohta T, Inokoshi J, Omura S
  Title
Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis.
  Journal
Gene 206:175-80 (1998)
DOI:10.1016/S0378-1119(97)00581-7

KEGG   REACTION: R06477Help
Entry
R06477                      Reaction                               

Definition
Avermectin B1a aglycone + S-Adenosyl-L-methionine <=> Avermectin A1a aglycone + S-Adenosyl-L-homocysteine
Equation
Comment
C5-O-methyltransferase,AveD
Reaction class
RC00003  C00019_C00021
RC00466  C11979_C11980
Enzyme
2.1.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14374  avermectin B 5-O-methyltransferase [EC:2.1.1.-]

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