KEGG   ORTHOLOGY: K14375Help
Entry
K14375                      KO                                     

Name
aveBI
Definition
dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14375  aveBI; dTDP-L-oleandrosyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14375  aveBI; dTDP-L-oleandrosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14375  aveBI; dTDP-L-oleandrosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-  
     K14375  aveBI; dTDP-L-oleandrosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K14375  aveBI; dTDP-L-oleandrosyltransferase
BRITE hierarchy
Other DBs
RN: R06484 R06485 R06486 R06487 R06488 R06489 R06490 R06491 R06492 R06493 R06494 R06495 R06496 R06497 R06498 R06499
CAZy: GT1
Genes
SMA: SAVERM_945(aveBI)
TaxonomyKoalaUniProt
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
Reference
  Authors
Zhang C, Albermann C, Fu X, Thorson JS
  Title
The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.
  Journal
J Am Chem Soc 128:16420-1 (2006)
DOI:10.1021/ja065950k

KEGG   REACTION: R06489Help
Entry
R06489                      Reaction                               

Definition
Avermectin B1a monosaccharide + dTDP-L-oleandrose <=> Avermectin B1a + dTDP
Equation
Comment
glycosyl transferase,AveB1
Reaction class
RC00005  C00363_C11921
RC00049  C11981_C11983
Enzyme
2.4.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14375  dTDP-L-oleandrosyltransferase [EC:2.4.1.-]

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