KEGG   ORTHOLOGY: K14375
Entry
K14375            Tight     KO                                     

Name
aveBI
Definition
dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14375  aveBI; dTDP-L-oleandrosyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14375  aveBI; dTDP-L-oleandrosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14375  aveBI; dTDP-L-oleandrosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-  
     K14375  aveBI; dTDP-L-oleandrosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K14375  aveBI; dTDP-L-oleandrosyltransferase
Other DBs
RN: R06484 R06485 R06486 R06487 R06488 R06489 R06490 R06491 R06492 R06493 R06494 R06495 R06496 R06497 R06498 R06499
CAZy: GT1
Genes
SMA: SAVERM_945(aveBI)
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
Reference
  Authors
Zhang C, Albermann C, Fu X, Thorson JS
  Title
The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.
  Journal
J Am Chem Soc 128:16420-1 (2006)
DOI:10.1021/ja065950k

KEGG   REACTION: R06489
Entry
R06489                      Reaction                               

Definition
Avermectin B1a monosaccharide + dTDP-L-oleandrose <=> Avermectin B1a + dTDP
Equation
Comment
glycosyl transferase,AveB1
Reaction class
RC00005  C00363_C11921
RC00049  C11981_C11983
Enzyme
2.4.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14375  dTDP-L-oleandrosyltransferase [EC:2.4.1.-]

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