KEGG   ORTHOLOGY: K14443
Entry
K14443                      KO                                     

Name
TOB
Definition
protein Tob/BTG
Pathway
ko03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    K14443  TOB; protein Tob/BTG
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K14443  TOB; protein Tob/BTG
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     K14443  TOB; protein Tob/BTG
  mRNA degradation factors
   3'-5' decay
    Other 3'-5' decay factors
     K14443  TOB; protein Tob/BTG
Genes
HSA: 10140(TOB1) 10766(TOB2) 10950(BTG3) 54766(BTG4) 694(BTG1) 7832(BTG2)
PTR: 451538(BTG4) 452121(BTG1) 458865(TOB2) 468406(TOB1) 740912(BTG2) 749692(BTG3)
PPS: 100968395(BTG1) 100972034(TOB1) 100985759(TOB2) 100990761(BTG2) 100991067(BTG3) 100994410(BTG4)
GGO: 101125593(TOB2) 101131176(BTG4) 101138900(BTG1) 101147328(TOB1) 101148696(BTG3)
PON: 100171740(TOB2) 100435196(BTG1) 100446758(BTG2) 100452041(TOB1) 100458944(BTG4) 100461465(BTG3)
NLE: 100580263(BTG3) 100591230(TOB1) 100597059(BTG1) 100597985(TOB2) 100601505(BTG2) 100603682(BTG4)
MCC: 703168(BTG2) 706873(TOB1) 707216(TOB2) 709946(BTG4) 710112(BTG1) 710579(BTG3)
MCF: 101865972(TOB2) 102115880(BTG1) 102118373(BTG4) 102120173(TOB1) 102138096(BTG3) 102141340(BTG2)
CSAB: 103218135(BTG3) 103223385(TOB2) 103230282(BTG2) 103238855(BTG1) 103242916(TOB1) 103248440(BTG4)
RRO: 104672376(TOB2) 104673919(BTG3) 104674486(BTG2) 104677333(BTG4) 104678609(BTG1) 104680292(TOB1)
RBB: 108515009(BTG2) 108516501(TOB1) 108527224 108527225 108528475(TOB2) 108536483(BTG4) 108536728(BTG3)
CJC: 100393479(TOB2) 100394994(BTG4) 100400853(BTG3) 100405025(BTG1) 100408523(TOB1) 100409458(BTG2) 100412192
SBQ: 101030965(TOB2) 101032251(BTG2) 101035112(BTG4) 101036747(TOB1) 101052594(BTG3) 101053099(BTG1)
MMU: 12226(Btg1) 12227(Btg2) 12228(Btg3) 194735(Btg1c) 22057(Tob1) 436199(Btg1b) 56057(Btg4) 57259(Tob2)
MCAL: 110297244(Btg2) 110301661(Btg4) 110303183(Btg1) 110306038(Tob1) 110310700(Tob2) 110311605(Btg3)
MPAH: 110322156(Btg2) 110326461(Btg1) 110328265(Btg4) 110329679(Btg3) 110331935(Tob1) 110334911(Tob2)
RNO: 170842(Tob1) 29618(Btg1) 29619(Btg2) 315159(Tob2) 315650(Btg4) 367975 54230(Btg3)
CGE: 100753614(Btg3) 100755272(Btg1) 100758626(Tob2) 100765745 100766229(Btg2) 100766688(Tob1) 100770985(Btg4)
NGI: 103726365(Btg1) 103731861(Btg2) 103733911(Btg4) 103738401(Tob1) 103743175(Btg3) 103743480(Tob2)
CCAN: 109674021(Btg3) 109681496(Tob1) 109689353(Tob2) 109695516(Btg4) 109699668(Btg2) 109701267(Btg1)
OCU: 100339845(TOB1) 100344815(BTG1) 100349594(BTG3) 100350876(BTG4) 100353216(TOB2) 100354553(BTG2)
TUP: 102475640(BTG4) 102476116 102477367(BTG2) 102481155(TOB1) 102487276 102500018(BTG3) 102500468(BTG1) 102501525(TOB2)
CFA: 100683517(TOB1) 100684605(BTG1) 111089952(BTG4) 481233(TOB2) 487695(BTG3) 488559(BTG2)
VVP: 112914547(BTG2) 112915070(BTG1) 112917662(BTG3) 112917875(TOB1) 112925885(BTG4) 112933989(TOB2)
AML: 100467646(BTG3) 100482458(TOB2) 100482779(BTG2) 100483106(BTG4) 100484707(BTG1) 100484798(TOB1)
UMR: 103657732(BTG2) 103660148(BTG1) 103660299(TOB1) 103662402(BTG4) 103673054(BTG3) 103674157(TOB2)
UAH: 113241727(TOB2) 113242519(BTG2) 113243853(BTG3) 113256171(BTG1) 113259791(BTG4) 113265636(TOB1)
ORO: 101365408(BTG3) 101375750(BTG1) 101375801(BTG2) 101379979(TOB1) 101381302 101385880(TOB2) 101386148(BTG4)
FCA: 101082205(BTG2) 101089792(BTG3) 101091649(BTG4) 101098267(TOB1) 101101647(BTG1) 105260772(TOB2)
PTG: 102952259(BTG1) 102953502(TOB2) 102956682(BTG2) 102962394(BTG4) 102966153(BTG3) 102967137(TOB1)
PPAD: 109247273(TOB1) 109256663(BTG2) 109265318(BTG1) 109265627(TOB2) 109277844(BTG3) 109278726(BTG4)
AJU: 106971331(BTG2) 106973097(BTG3) 106973393(BTG1) 106979938(TOB2) 106984418(BTG4) 106986754(TOB1)
BTA: 281032(BTG1) 507934(TOB2) 519995(BTG4) 539364(BTG2) 541054(BTG3) 768016(TOB1)
BOM: 102264973(BTG4) 102269714(BTG2) 102271631(BTG3) 102274438(TOB2) 102277659(TOB1) 106701628
BIU: 109558972(BTG1) 109559859(TOB2) 109560043(BTG3) 109570024(BTG4) 109570512(BTG2) 109573591 109574239
BBUB: 102391590(BTG4) 102396927(TOB2) 102397803(BTG2) 102398370(BTG3) 102398846(BTG1) 102412865(TOB1)
CHX: 100861579(BTG1) 102175142(BTG4) 102176267(BTG3) 102178391(TOB1) 102187789(BTG2) 102189933(TOB2)
OAS: 100217400(BTG1) 100620046(TOB2) 100620047(BTG2) 100620049(BTG3) 101103823(TOB1) 101107134(BTG4)
SSC: 100048932(BTG2) 100048957(BTG3) 100101473(BTG1) 100144440(TOB1) 100514308(BTG4) 110260627(TOB2)
CFR: 102503705 102504534(BTG4) 102511283(BTG2) 102514585(TOB2) 102515218(TOB1) 102516093(BTG3) 102521231(BTG1)
CDK: 105086818(BTG3) 105091902(TOB2) 105092095(BTG2) 105092208(BTG1) 105094213(BTG4) 105097736(TOB1)
BACU: 102999833(BTG3) 103000964(TOB2) 103002894(BTG4) 103004439(BTG2) 103007363(TOB1) 103009536(BTG1)
LVE: 103070867(BTG4) 103076131(BTG3) 103077357(TOB2) 103081890(TOB1) 103086874(BTG2) 103090103
OOR: 101269375(BTG1) 101277794 101277921(BTG4) 101287589(TOB1) 101287689(BTG2) 101288278(BTG3) 101289589(TOB2)
DLE: 111163579(BTG1) 111166397(TOB1) 111168052(BTG4) 111175540(BTG3) 111183874 111184802(BTG2) 111186334(TOB2)
PCAD: 102973303(BTG2) 102974562(BTG1) 102976037(BTG4) 102979843(TOB1) 102980118 102980348(BTG3) 102980870(TOB2) 112065122
ECB: 100053122(BTG2) 100054048(BTG3) 100055713(TOB2) 100056451(TOB1) 100070324(BTG4) 100629230(BTG1)
EPZ: 103549551(TOB1) 103555606(BTG4) 103556109(TOB2) 103562553(BTG1) 103563861(BTG2) 103565903(BTG3)
EAI: 106823957(BTG3) 106824099(BTG2) 106826480(TOB1) 106831164(BTG1) 106840337(BTG4) 106845928(TOB2)
MYB: 102238930(BTG4) 102245347(BTG1) 102246373(BTG2) 102248369(BTG3) 102259223(TOB2) 102263921(TOB1)
MYD: 102751671(BTG4) 102755542(BTG1) 102758616(TOB2) 102767619(BTG2) 102768869(BTG3) 102771873(TOB1)
MNA: 107529833(TOB1) 107529982(BTG4) 107534984(TOB2) 107538914(BTG1) 107539281(BTG2) 107544708(BTG3)
HAI: 109371979(BTG1) 109380653(TOB1) 109386434(BTG2) 109388690(BTG4) 109391721(BTG3) 109392267(TOB2)
DRO: 112306763(BTG3) 112314352(BTG1) 112314416(BTG4) 112316414(TOB1) 112317844(BTG2) 112321859(TOB2)
PALE: 102879693(BTG2) 102887122(BTG1) 102889076(BTG4) 102891712(TOB2) 102894615(TOB1) 102896420(BTG3)
RAY: 107504502(TOB1) 107505587(TOB2) 107508130(BTG2) 107512690(BTG3) 107518653(BTG1) 107521181(BTG4)
MJV: 108390739(BTG4) 108395561(BTG1) 108399632(TOB2) 108402782(TOB1) 108403558(BTG3) 108409935(BTG2)
LAV: 100655160(BTG2) 100658674(BTG3) 100658925(BTG1) 100659945(TOB2) 100662966(BTG4) 100665416(TOB1)
MDO: 100011644(BTG1) 100012985(TOB1) 100013053(TOB2) 100016025(BTG2) 100030262 100032346(BTG4)
SHR: 100919144(BTG4) 100921611(BTG2) 100922495(TOB2) 100923528(BTG1) 100927519(TOB1) 116421506
PCW: 110192975 110198463(TOB1) 110205840(TOB2) 110210698(BTG4) 110219586(BTG2) 110221771(BTG1)
OAA: 100075807(TOB2) 100082540(BTG1) 100086417(BTG4) 100090433(BTG3) 100090471(TOB1) 114813255(BTG2)
GGA: 395225(TOB1) 396295(BTG1) 415950(BTG1L) 417992(TOB2) 419781(BTG4) 419932(BTG2)
MGP: 100544164(TOB2) 100545092(BTG1) 100546374(BTG4) 100550002(TOB1) 100550022(BTG2) 104913142
CJO: 107311516(BTG1) 107313153(TOB2) 107319665 107322363(TOB1) 107324233(BTG4) 107324908(BTG2)
NMEL: 110387734(BTG4) 110388281(BTG2) 110392155(TOB2) 110403479(BTG1) 110404879 110407383(TOB1)
APLA: 101793601(BTG2) 101795306(TOB2) 101796375(BTG4) 101802852(TOB1) 101804984(BTG1) 113841361
ACYG: 106034691(TOB1) 106036971(BTG1) 106039759(BTG4) 106045278(TOB2) 106045843(BTG2)
LSR: 110469360(BTG1) 110469940 110474980(BTG2) 110475952(BTG4) 110483100(TOB2) 110484452(TOB1)
SCAN: 103813296(TOB2) 103813651(BTG1) 103816947 103819814(TOB1) 103822990(BTG4) 103824512
GFR: 102036301(BTG1) 102037849(BTG2) 102039299(TOB2) 102042144(TOB1) 102043238 102045365(BTG4)
FAB: 101808591(TOB2) 101815050(BTG1) 101816215(BTG4) 101816844 101822216(TOB1)
PHI: 102099530(BTG2) 102102431 102104179(BTG4) 102104476(TOB2) 102109972(TOB1) 102113240(BTG1)
PMAJ: 107204604(BTG1) 107205007(TOB2) 107210151 107212629(TOB1) 107214358(BTG4) 107214782(BTG2)
CCAE: 111933546(BTG1) 111934516(TOB2) 111935333 111937363(TOB1) 111939402(BTG4) 111939695(BTG2)
CCW: 104692090(BTG4) 104692522 104694281(TOB1) 104696349(TOB2) 104698442(BTG1)
ETL: 114055942(TOB1) 114058035(TOB2) 114058797 114064637(BTG1) 114067501(BTG2) 114067836(BTG4)
FPG: 101913881(BTG2) 101914831(BTG1) 101916024(TOB2) 101918587(TOB1) 101924677(BTG4)
FCH: 102046395(BTG1) 102049769(TOB2) 102053208(TOB1) 102053297(BTG4) 102060168(BTG2)
CLV: 102083651(TOB2) 102088978(TOB1) 102090493(BTG2) 102090707(BTG4) 102096627(BTG1)
EGZ: 104125421(TOB1) 104125738(BTG2) 104125914(BTG4) 104132369(BTG1) 104134248(TOB2)
NNI: 104008765(BTG4) 104011694(BTG1) 104013144(BTG2) 104020691(TOB1) 104021644(TOB2)
ACUN: 113486807(TOB1) 113488524(BTG4) 113488780 113491320(TOB2) 113491504(BTG1)
PADL: 103914680(BTG1) 103915180(TOB2) 103916681(TOB1) 103919862(BTG2) 103921551(BTG4)
AAM: 106483940(BTG2) 106485150(TOB1) 106488180(BTG1) 106488437(TOB2) 106495961(BTG4)
ASN: 102369498 102369834(BTG1) 102371140(TOB2) 102373713(TOB1) 102383214(BTG2) 102387695(BTG4) 102388694
AMJ: 102558693 102560710(BTG4) 102565886(BTG2) 102568514(BTG1) 102572296(TOB1) 102576158(TOB2) 106738241
PSS: 102446080 102448436(BTG2) 102451193(TOB1) 102452265(BTG4) 102454057(TOB2) 102456067(BTG1)
CMY: 102929772(TOB1) 102935550 102936947(BTG1) 102938993(BTG2) 102945308(TOB2)
CPIC: 101935111(BTG1) 101937059 101938878(BTG2) 101941502(TOB2) 101942360(BTG4) 101953271(TOB1) 101953478
ACS: 100554385(btg4) 100559132(btg2) 100561441(btg1) 100561814(tob1) 100566448 103278861(tob2)
PVT: 110070243(BTG1) 110076034(TOB2) 110079562(BTG4) 110080725(BTG2) 110085968 110086531 110091058(TOB1)
PBI: 103050428(BTG1) 103060040(TOB1) 103061733(TOB2) 103062620(BTG2) 103067186(BTG4) 103067266
PMUR: 107284511(BTG4) 107284762(BTG1) 107285419(TOB2) 107287219(TOB1) 107293188 107293266 107293966(BTG2)
PMUA: 114585652(BTG4) 114590162(TOB1) 114591611 114599275(BTG2) 114603477 114605197(TOB2) 114605414(BTG1)
XLA: 100137619 108701157(tob1.L) 108705048 108705053 108707908 379067(btg1.L) 380519(btg1.S) 394334(btg4.L) 397913(btg4.S) 398757(tob1.S) 399353(tob2.L) 446814(MGC75753.L) 447135(tob2.S) 496081(btg2.S) 496384(btg-x) 733441 734153(btg3.S) 734504(btg5.L) 735063(MGC75753.S)
XTR: 100038251(btg3) 394487(MGC75753) 394522(btg1) 394613(btg5.3) 496422(btg2) 548967(tob2) 549151(btg4) 549365(tob1) 613060(btg5.2) 733731(btg5.1)
DRE: 100007655 100538016(si:dkey-79d12.5) 114432(btg1) 30079(btg2) 378946(btg4) 386629(tob1a) 406245(tob1b) 492479(btg3) 492503(si:dkey-42i9.4)
DME: Dmel_CG9214(Tob)
DER: 6550552
DSE: 6620215
DSI: Dsimw501_GD12260(Dsim_GD12260)
DSR: 110184595
DPE: 6599348
DMN: 108157425
DWI: 6648944
DAZ: 108619813
DNV: 115564541
DHE: 111592713
MDE: 101894598
LCQ: 111687302
AAG: 5565301
BMOR: 101744020
BMAN: 114243182
PMAC: 106718516
PRAP: 110994602
HAW: 110371516
TNL: 113504582
DPTE: 113798141
CEL: CELE_C03C11.2(fog-3)
CBR: CBG12385(Cbr-fog-3)
BMY: Bm1_46245
TSP: Tsp_07899
SHX: MS3_03917
EGL: EGR_06576
AQU: 100638393
DDI: DDB_G0285069(btg)
DFA: DFA_05298(btg)
NGR: NAEGRDRAFT_81040(AM59)
 » show all
Reference
  Authors
Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F
  Title
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
  Journal
J Biol Chem 284:13244-55 (2009)
DOI:10.1074/jbc.M809250200
  Sequence
[hsa:10140]
Reference
  Authors
Doidge R, Mittal S, Aslam A, Winkler GS
  Title
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
  Journal
PLoS One 7:e51331 (2012)
DOI:10.1371/journal.pone.0051331
  Sequence
[hsa:7832 10140]

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