KEGG   ORTHOLOGY: K14468Help
Entry
K14468                      KO                                     

Name
mcr
Definition
malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298]
Pathway
ko00640  Propanoate metabolism
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00376  3-Hydroxypropionate bi-cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K14468  mcr; malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K14468  mcr; malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.298  3-hydroxypropionate dehydrogenase (NADP+)
     K14468  mcr; malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.75  malonyl-CoA reductase (malonate semialdehyde-forming)
     K14468  mcr; malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
BRITE hierarchy
Other DBs
RN: R00740 R09289
GO: 0035527
Genes
RRS: RoseRS_3201
RCA: Rcas_2929
CAU: Caur_2614
CHL: Chy400_2826
CAG: Cagg_1256
CTM: Cabther_B0159
TaxonomyKoalaUniProt
Reference
  Authors
Zarzycki J, Brecht V, Muller M, Fuchs G
  Title
Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.
  Journal
Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106
Reference
  Authors
Hugler M, Menendez C, Schagger H, Fuchs G
  Title
Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:2404-10 (2002)
DOI:10.1128/JB.184.9.2404-2410.2002
  Sequence
[cau:Caur_2614]

KEGG   ORTHOLOGY: K15017Help
Entry
K15017                      KO                                     

Name
K15017
Definition
malonyl-CoA/succinyl-CoA reductase (NADPH) [EC:1.2.1.75 1.2.1.76]
Pathway
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00374  Dicarboxylate-hydroxybutyrate cycle
M00375  Hydroxypropionate-hydroxybutylate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K15017  K15017; malonyl-CoA/succinyl-CoA reductase (NADPH)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.75  malonyl-CoA reductase (malonate semialdehyde-forming)
     K15017  K15017; malonyl-CoA/succinyl-CoA reductase (NADPH)
    1.2.1.76  succinate-semialdehyde dehydrogenase (acylating)
     K15017  K15017; malonyl-CoA/succinyl-CoA reductase (NADPH)
BRITE hierarchy
Other DBs
RN: R00740 R09280
COG: COG0136
Genes
STO: STK_21710(mcr_scr)
SSO: SSO2178(asd-2)
SOL: Ssol_2908
SSOA: SULA_2921(asd)
SSOL: SULB_2921(asd)
SSOF: SULC_2918(asd)
SAI: Saci_2147 Saci_2370
SACN: SacN8_10450 SacN8_11535
SACR: SacRon12I_10705 SacRon12I_11780
SACS: SUSAZ_09800 SUSAZ_11160
SID: M164_2777
SII: LD85_3126
SIH: SiH_2755
SIR: SiRe_2691
SIC: SiL_2637
MSE: Msed_0709
MCN: Mcup_1427
MHK: DFR87_03300(asd)
MPRU: DFR88_03035(asd)
AHO: Ahos_2348
ABRI: DFR85_01565(asd)
ASUL: DFR86_02340(asd)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
  Sequence
[mse:Msed_0709]
Reference
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J Bacteriol 193:1201-11 (2011)
DOI:10.1128/JB.01156-10

KEGG   ENZYME: 1.2.1.76Help
Entry
EC 1.2.1.76                 Enzyme                                 

Name
succinate-semialdehyde dehydrogenase (acylating);
succinyl-coA reductase;
coenzyme-A-dependent succinate-semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+ [RN:R09280]
Reaction(KEGG)
Substrate
succinate semialdehyde [CPD:C00232];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
succinyl-CoA [CPD:C00091];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].
History
EC 1.2.1.76 created 2009
Pathway
ec00650  Butanoate metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15017  malonyl-CoA/succinyl-CoA reductase (NADPH)
K15038  succinyl-CoA reductase
K18119  succinate-semialdehyde dehydrogenase
Genes
BGJ: AWC36_10870
METI: DK427_23010
CKL: CKL_3015(sucD)
CKR: CKR_2663
CSQ: CSCA_3620
CEU: A7L45_11960
CRS: FQB35_12335
LACY: A4V08_31365
CDF: CD630_23420(sucD)
PDC: CDIF630_02581(sucD)
CDC: CD196_2185(sucD)
CDL: CDR20291_2231(sucD)
PDF: CD630DERM_23420(sucD)
PGI: PG_0687(sucD)
PGN: PGN_0723
PGT: PGTDC60_1813(sucD)
PCRE: NCTC12858_01805(sucD)
TFO: BFO_1488
STO: STK_00640 STK_21710(mcr_scr)
SSO: SSO1629(gapN-1) SSO1842(gapN-2) SSO2178(asd-2)
SOL: Ssol_2908
SSOA: SULA_2921(asd)
SSOL: SULB_2921(asd)
SSOF: SULC_2918(asd)
MCN: Mcup_1427
ASUL: DFR86_02340(asd)
PIS: Pisl_0249
PCL: Pcal_1387
PYR: P186_0719
POG: Pogu_1297
TNE: Tneu_0421
CMA: Cmaq_0073
TTN: TTX_1101
 » show all
Taxonomy
Reference
1  [PMID:8444151]
  Authors
Sohling B, Gottschalk G
  Title
Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri.
  Journal
Eur J Biochem 212:121-7 (1993)
DOI:10.1111/j.1432-1033.1993.tb17641.x
  Sequence
Reference
2  [PMID:17041055]
  Authors
Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G
  Title
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.
  Journal
J Bacteriol 188:8551-9 (2006)
DOI:10.1128/JB.00987-06
Reference
3  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
  Sequence
[mse:Msed_0709]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.76
IUBMB Enzyme Nomenclature: 1.2.1.76
ExPASy - ENZYME nomenclature database: 1.2.1.76
BRENDA, the Enzyme Database: 1.2.1.76

KEGG   REACTION: R00740Help
Entry
R00740                      Reaction                               

Name
3-oxopropanoate:NADP+ oxidoreductase (CoA-malonylating)
Definition
3-Oxopropanoate + CoA + NADP+ <=> Malonyl-CoA + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083
RC00184  C00083_C00222
Enzyme
Pathway
rn00640  Propanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00375  Hydroxypropionate-hydroxybutylate cycle
M00376  3-Hydroxypropionate bi-cycle
Orthology
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298]
K15017  malonyl-CoA/succinyl-CoA reductase (NADPH) [EC:1.2.1.75 1.2.1.76]
Other DBs
RHEA: 26449

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