KEGG   ORTHOLOGY: K14631
Entry
K14631                      KO                                     

Name
actVB
Definition
flavin reductase ActVB [EC:1.5.1.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14631  actVB; flavin reductase ActVB
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.-  
     K14631  actVB; flavin reductase ActVB
Other DBs
RN: R05705
Genes
BUE: BRPE67_CCDS03520
BUO: BRPE64_CCDS02020
CID: P73_0185
PABY: Ga0080574_TMP226
NOV: TQ38_005245
CVA: CVAR_0219
NNO: NONO_c51280
NOZ: DMB37_03455
NAD: NCTC11293_02475(hsaB_3)
ROP: ROP_46610
SCO: SCO5092(actVB)
SHY: SHJG_7334
SLV: SLIV_12925(actVB)
SRW: TUE45_01562(snaC)
SLE: sle_03080(sle_03080)
STRD: NI25_26845
SALF: SMD44_00656(actVB)
SALJ: SMD11_0681(actVB) SMD11_1393(actVB)
SLX: SLAV_40520(snaC2)
SFK: KY5_7707c
NDK: I601_2566(snaC)
TBI: Tbis_2517
SAQ: Sare_0591
ASE: ACPL_2178(ntaB) ACPL_6076
CAI: Caci_6495
RXY: Rxyl_1781
 » show all
Reference
  Authors
Valton J, Filisetti L, Fontecave M, Niviere V
  Title
A two-component flavin-dependent monooxygenase involved in actinorhodin biosynthesis in Streptomyces coelicolor.
  Journal
J Biol Chem 279:44362-9 (2004)
DOI:10.1074/jbc.M407722200
Reference
  Authors
Valton J, Fontecave M, Douki T, Kendrew SG, Niviere V
  Title
An aromatic hydroxylation reaction catalyzed by a two-component FMN-dependent Monooxygenase. The ActVA-ActVB system from Streptomyces coelicolor.
  Journal
J Biol Chem 281:27-35 (2006)
DOI:10.1074/jbc.M506146200
Reference
  Authors
Ellis HR
  Title
The FMN-dependent two-component monooxygenase systems.
  Journal
Arch Biochem Biophys 497:1-12 (2010)
DOI:10.1016/j.abb.2010.02.007
Reference
  Authors
Filisetti L, Fontecave M, Niviere V
  Title
Mechanism and substrate specificity of the flavin reductase ActVB from Streptomyces coelicolor.
  Journal
J Biol Chem 278:296-303 (2003)
DOI:10.1074/jbc.M209689200

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