KEGG   ORTHOLOGY: K14633Help
Entry
K14633                      KO                                     

Name
gra6, RED2
Definition
ketoreductase RED2 [EC:1.1.1.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14633  gra6, RED2; ketoreductase RED2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K14633  gra6, RED2; ketoreductase RED2
BRITE hierarchy
Other DBs
RN: R09309 R09310
Genes
SVE: SVEN_1543
SDV: BN159_2510
SVT: SVTN_09180 SVTN_18790
STRE: GZL_p00221
AMS: AMIS_50460
CAI: Caci_6492
AG: BAD51477(gra-orf6)
TaxonomyKoalaUniProt
Reference
  Authors
Ichinose K, Taguchi T, Bedford DJ, Ebizuka Y, Hopwood DA
  Title
Functional complementation of pyran ring formation in actinorhodin biosynthesis in Streptomyces coelicolor A3(2) by ketoreductase genes for granaticin biosynthesis.
  Journal
J Bacteriol 183:3247-50 (2001)
DOI:10.1128/JB.183.10.3247-3250.2001
Reference
  Authors
Taguchi T, Ebizuka Y, Hopwood DA, Ichinose K
  Title
A new mode of stereochemical control revealed by analysis of the biosynthesis of dihydrogranaticin in Streptomyces violaceoruber Tu22.
  Journal
J Am Chem Soc 123:11376-80 (2001)
DOI:10.1021/ja015981+
Reference
  Authors
Taguchi T, Kunieda K, Takeda-Shitaka M, Takaya D, Kawano N, Kimberley MR, Booker-Milburn KI, Stephenson GR, Umeyama H, Ebizuka Y, Ichinose K
  Title
Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics.
  Journal
Bioorg Med Chem 12:5917-27 (2004)
DOI:10.1016/j.bmc.2004.08.026

KEGG   REACTION: R09310Help
Entry
R09310                      Reaction                               

Definition
(R)-Chiral alcohol <=> (R)-Hemiketal
Equation
Reaction class
RC02484  C18355_C18357
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01130  Biosynthesis of antibiotics
Orthology
K14633  ketoreductase RED2 [EC:1.1.1.-]

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