KEGG   ORTHOLOGY: K14732
Entry
K14732            Tight     KO                                     
Symbol
K14732
Name
limonene hydroxylase [EC:1.14.14.51 1.14.14.52 1.1.1.243 1.1.1.144]
Pathway
map00903  Limonene degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00903 Limonene degradation
    K14732  K14732; limonene hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.144  perillyl-alcohol dehydrogenase
     K14732  K14732; limonene hydroxylase
    1.1.1.243  carveol dehydrogenase
     K14732  K14732; limonene hydroxylase
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K14732  K14732; limonene hydroxylase
    1.14.14.52  (S)-limonene 7-monooxygenase
     K14732  K14732; limonene hydroxylase
Other DBs
RN: R02468 R02470 R03114 R03945
GO: 0018675 0018676 0018459 0018457
Genes
AG: AAC25032
Reference
  Authors
Cheong TK, Oriel PJ
  Title
Cloning and expression of the limonene hydroxylase of Bacillus stearothermophilus BR388 and utilization in two-phase limonene conversions.
  Journal
Appl Biochem Biotechnol 84-86:903-15 (2000)
DOI:10.1385/ABAB:84-86:1-9:903

KEGG   ORTHOLOGY: K07381
Entry
K07381            Tight     KO                                     
Symbol
CYP71D18
Name
(S)-limonene 6-monooxygenase [EC:1.14.14.51]
Pathway
map00902  Monoterpenoid biosynthesis
map00903  Limonene degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K07381  CYP71D18; (S)-limonene 6-monooxygenase
   00903 Limonene degradation
    K07381  CYP71D18; (S)-limonene 6-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07381  CYP71D18; (S)-limonene 6-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K07381  CYP71D18; (S)-limonene 6-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP71 family
   K07381  CYP71D18; (S)-limonene 6-monooxygenase
Other DBs
RN: R02468
GO: 0018675
Genes
AG: AAD44150(CYP71D18)
Reference
  Authors
Lupien S, Karp F, Wildung M, Croteau R
  Title
Regiospecific cytochrome P450 limonene hydroxylases from mint (Mentha) species: cDNA isolation, characterization, and functional expression of (-)-4S-limonene-3-hydroxylase and (-)-4S-limonene-6-hydroxylase.
  Journal
Arch Biochem Biophys 368:181-92 (1999)
DOI:10.1006/abbi.1999.1298
  Sequence
Reference
  Authors
Wust M, Little DB, Schalk M, Croteau R
  Title
Hydroxylation of limonene enantiomers and analogs by recombinant (-)-limonene 3- and 6-hydroxylases from mint (Mentha) species: evidence for catalysis within sterically constrained active sites.
  Journal
Arch Biochem Biophys 387:125-36 (2001)
DOI:10.1006/abbi.2000.2248

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