KEGG ORTHOLOGY: K14938

ORTHOLOGY: K14938

Entry

K14938                      KO

Symbol

NVD, DAF36

Name

cholesterol 7-desaturase [EC:1.14.19.21]

Pathway

map00981

Insect hormone biosynthesis

map04212

Longevity regulating pathway - worm

Reaction

R11007

cholesterol,NADH:oxygen oxidoreductase (7,8 dehydrogenating)

R11008

cholesterol,NADPH:oxygen oxidoreductase (7,8 dehydrogenating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00981 Insect hormone biosynthesis
    K14938  NVD, DAF36; cholesterol 7-desaturase
09150 Organismal Systems
  09149 Aging
   04212 Longevity regulating pathway - worm
    K14938  NVD, DAF36; cholesterol 7-desaturase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.21  cholesterol 7-desaturase
     K14938  NVD, DAF36; cholesterol 7-desaturase

Genes

GGA:

PCOC:

MGP:

CJO:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

ETL:

FPG:

FCH:

CLV:

EGZ:

NNI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

BREG:

FGA:

GSTE:

OHA:

NNT:

SHAB:

PGUU:

AVIT:

CVF:

RTD:

CUCA:

TEO:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

114590059 114592319 114592320

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108698103(XB5992703.L) 779348(XB5992703.S)

XTR:

NPR:

RTEM:

BBUF:

BGAR:

122919655 122946149 122946150 122946762

MUO:

115472163

GSH:

117367721

DRE:	436885(zgc:92275)

SRX:	107739715 107754619

SANH:

SGH:

CCAR:

CAUA:

CGIB:

127941321 127985608(zgc:92275)

PTET:

122326366(zgc:92275)

LROH:

127153055(zgc:92275)

OMC:	131528618(zgc:92275)

PPRM:

120490655(zgc:92275)

RKG:	130090783(zgc:92275)

MAMB:

125252778(zgc:92275)

CIDE:

127503337 127525455

MASI:

127428623(zgc:92275) 127431275

TROS:

130570563(zgc:92275)

TDW:	130407467(zgc:92275)

MANU:

129424406(zgc:92275)

IPU:	108279335(zgc:92275)

IFU:	128622753(zgc:92275)

PHYP:

113535713

SMEO:

124397555(zgc:92275)

TFD:	113646467(zgc:92275)

TVC:	132860435(zgc:92275)

TRN:	134330418(zgc:92275)

AMEX:

103022783(zgc:92275)

CMAO:

118820347(zgc:92275)

EEE:

113573769

CHAR:

105902521(zgc:92275)

TRU:

101069484

TFS:	130517529(zgc:92275)

TNG:	GSTEN00005122G001

LCO:

104936331

NCC:

104958128

TBEN:

117478759(zgc:92275)

CGOB:

115016994

PGEO:

117456530(zgc:92275)

GACU:

117539975(zgc:92275)

EMAC:

134868721(zgc:92275)

ELY:	117269523(zgc:92275)

EFO:	125906002(zgc:92275)

PLEP:

121960166(zgc:92275)

SLUC:

116034845(zgc:92275)

ECRA:

117959585(zgc:92275)

ESP:

116704543

PFLV:

114571346

GAT:	120831891(zgc:92275)

PPUG:

119226249(zgc:92275)

AFB:	129102857(zgc:92275)

CLUM:

117740739(zgc:92275)

PSWI:

130205659(zgc:92275)

MSAM:

119914737(zgc:92275)

SCHU:

122865580(zgc:92275)

CUD:	121524811(zgc:92275)

ALAT:

119030527(zgc:92275)

MZE:

101475379

ONL:

100702604

OAU:	116319597(zgc:92275)

OLA:	101170113 105358384

OML:	112162855(zgc:92275)

CSAI:

133454753(zgc:92275)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122819185(zgc:92275)

PPRL:

129366705(zgc:92275)

CVG:

107102253

CTUL:

119772015(zgc:92275)

GMU:	124873052(zgc:92275)

NFU:

107375133

KMR:	108241378(zgc:92275)

ALIM:

106513553 106533739

NWH:	119424478(zgc:92275)

AOCE:

111571560

MCEP:

124996303(zgc:92275)

CSEM:

103389306

POV:

109640312

SSEN:

122758614(zgc:92275)

HHIP:

117771622(zgc:92275)

HSP:	118125834(zgc:92275)

PPLT:

128425254(zgc:92275)

SMAU:

118284944(zgc:92275)

LCF:	108894422(zgc:92275)

SDU:

111238492

SLAL:

111650147

XGL:	120806669(zgc:92275)

SSCV:

125979739(zgc:92275)

SBIA:

133491127(zgc:92275)

PEE:	133414054(zgc:92275)

PTAO:

133490188(zgc:92275)

BPEC:

110172811

BSPL:

114866897(zgc:92275)

SJO:	128380674(zgc:92275)

SASA:

106565467

STRU:

115159509

OTW:	112219356(zgc:92275)

OMY:	110523638(zgc:92275)

OGO:	124048900(zgc:92275)

ONE:

115123474

OKI:	109868855 109873612

OKE:	118387577(zgc:92275)

SALP:

111961562

SNH:	120025543(zgc:92275)

CCLU:

ELS:

SFM:

PKI:

AANG:

118206903(zgc:92275)

LOC:

102691906

PSPA:

121306732(zgc:92275)

ARUT:

117396731(zgc:92275) 117974032

PSEX:

120542954(zgc:92275)

LCM:

102356630

CMK:	103183010(zgc:92275)

RTP:	109938749(zgc:92275)

CPLA:

122564641(zgc:92275)

HOC:	132826018(zgc:92275)

LERI:

129712167(zgc:92275)

PMRN:

116957437

LRJ:

133361177

BFO:	118414807 118420780

BBEL:

109466201 109482902

CIN:	100176071 100177386

SCLV:

120327085 120337189 120337310 120337807 120343680

SPU:

592788

LPIC:

129277485 129277488

APLC:

110977513 110977515 110977953 110977954 110980559 110985648 110986001

ARUN:

117289138

AJC:

117100009

SKO:

100374996

DME:	Dmel_CG40050(nvd)

DER:

26527012

DYA:	Dyak_GE28326

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI25582

DAZ:

DNV:

DHE:

CCAT:

BDR:

AOQ:

TDA:

SCAC:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ006320

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100119735 100119998

CSOL:

TPRE:

LHT:

LBD:

MDL:	103572543 103573967

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

BMOR:

733067(Nvd)

BMAN:

114251510

MSEX:

115451343

DPL:	KGM_215135

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119838466 119838565

CCRC:

123704539 123704683 123704684

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:	114360096 114362450

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

109029997 109030017 109030061 109030063 109030501 109030523 109032522 109036892 109043093

DCI:	103506558 103506559

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM458690

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110842436 110846580 110846657 110848904 110854554 110854966 110857831 110861595

DPX:	DAPPUDRAFT_18823 DAPPUDRAFT_308492 DAPPUDRAFT_311567

DMK:	116926277 116932277

DPZ:	124315332 124335932

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111708930 111716479

LSM:

TCF:

PPOI:

ISC:

DSV:	119437085 119437095 119437107 119437150 119451449 119451477 119451504

RSAN:

119379265 119386907 119398458 119398507

RMP:	119161394 119161395 119162163 119162376

TUT:

DPTE:

DFR:

PTEP:

ABRU:

UDV:	129221062 129224184

SDM:

118201532

LPOL:

106459473

CEL:	CELE_C12D8.5(daf-36)

CBR:	CBG_09553(Cbr-daf-36)

CRQ:	GCK72_017584 GCK72_025847

NAI:	NECAME_15984

BMY:	BM_BM11695(Bma-daf-36)

LOA:	LOAG_18474

HRO:	HELRODRAFT_107375 HELRODRAFT_87564

LGI:	LOTGIDRAFT_130105

PVUL:

126814563

PCAN:

112575618

BGT:

106064009

GAE:	121382624 121384285

HRF:	124138371 124138372

HRJ:	124267628 124267629

CRG:	105340983 105340985

CANU:

128155544 128156847

CVN:	111123313 111123314 111126872 111127059

OED:	125681243 125681336

MYI:

PMAX:

MCAF:

MMER:

RPHI:

132754004 132754005 132754007

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106164789 106177872

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

AQU:

NCOL:

SRE:	PTSG_07043

ACAN:

ACA1_048400 ACA1_164170

PTM:	GSPATT00025959001 GSPATT00032008001 GSPATT00035183001 GSPATT00035190001 GSPATT00036085001

SMIN:

v1.2.004636.t1(symbB.v1.2.004636.t1)

AAF:	AURANDRAFT_31508

NGR:	NAEGRDRAFT_78012 NAEGRDRAFT_78121

FAU:	Fraau_1241

HALC:

EY643_18085

SOK:	D0B54_08475

BMJ:	BMULJ_05577

BMU:

Bmul_5949

BMK:

DM80_6398

VBO:	CKY39_30055

SRC:	M271_41250

SMAL:

SMALA_1177

SAUO:

BV401_09655

SGV:	B1H19_02775

TCU:

Tcur_2516

PSEA:

WY02_22000

PSEH:

XF36_05215

AYM:	YM304_00970

TER:

Tery_0576

» show all

Reference

PMID:16763204

Authors

Yoshiyama T, Namiki T, Mita K, Kataoka H, Niwa R

Title

Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth.

Journal

Development 133:2565-74 (2006)
DOI:10.1242/dev.02428

Sequence

[bmor:733067] [dme:Dmel_CG40050]

Reference

PMID:21632547

Authors

Yoshiyama-Yanagawa T, Enya S, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi S, Asashima M, Kataoka H, Niwa R

Title

The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.

Journal

J Biol Chem 286:25756-62 (2011)
DOI:10.1074/jbc.M111.244384

Sequence

[cel:CELE_C12D8.5]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (1788)   
   KEGG GENES (581)   
   KEGG MGENES (436)   
   RefGene (765)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (1800)   

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