KEGG   ORTHOLOGY: K15232Help
Entry
K15232                      KO                                     

Name
ccsA
Definition
citryl-CoA synthetase large subunit [EC:6.2.1.18]
Pathway
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K15232  ccsA; citryl-CoA synthetase large subunit
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.18  citrate---CoA ligase
     K15232  ccsA; citryl-CoA synthetase large subunit
BRITE hierarchy
Other DBs
RN: R01322
GO: 0047779
Genes
DKU: Desku_1349
CWO: Cwoe_4214
CTM: Cabther_A1178
AAE: aq_1306(sucC1)
HYA: HY04AAS1_1267
HHO: HydHO_1257
HYS: HydSN_1287
HTH: HTH_1737(ccsA)
HTE: Hydth_1719
TAL: Thal_0201
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Aoshima M, Ishii M, Igarashi Y
  Title
A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol Microbiol 52:763-70 (2004)
DOI:10.1111/j.1365-2958.2004.04010.x

KEGG   ORTHOLOGY: K15233Help
Entry
K15233                      KO                                     

Name
ccsB
Definition
citryl-CoA synthetase small subunit
Pathway
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K15233  ccsB; citryl-CoA synthetase small subunit
BRITE hierarchy
Other DBs
RN: R01322
Genes
AAE: aq_1888(sucD1)
HYA: HY04AAS1_1266
HHO: HydHO_1256
HYS: HydSN_1286
HTH: HTH_0201(ccsB)
HTE: Hydth_0200
TAL: Thal_0200
TaxonomyKoalaUniProt
Reference
  Authors
Aoshima M, Ishii M, Igarashi Y
  Title
A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol Microbiol 52:763-70 (2004)
DOI:10.1111/j.1365-2958.2004.04010.x

KEGG   ENZYME: 6.2.1.18Help
Entry
EC 6.2.1.18                 Enzyme                                 

Name
citrate---CoA ligase;
citryl-CoA synthetase;
citrate:CoA ligase;
citrate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
citrate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA [RN:R01322]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
citrate [CPD:C00158];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
(3S)-citryl-CoA [CPD:C00566]
Comment
The enzyme is a component of EC 2.3.3.8 ATP citrate synthase.
History
EC 6.2.1.18 created 1986
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15232  citryl-CoA synthetase large subunit
Genes
DKU: Desku_1349
CWO: Cwoe_4214
CTM: Cabther_A1178
AAE: aq_1306(sucC1)
HYA: HY04AAS1_1267
HHO: HydHO_1257
HYS: HydSN_1287
HTH: HTH_1737(ccsA)
HTE: Hydth_1719
TAL: Thal_0201
 » show all
Taxonomy
Reference
1  [PMID:6749502]
  Authors
Lill U, Schreil A, Eggerer H.
  Title
Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase.
  Journal
Eur J Biochem 125:645-50 (1982)
DOI:10.1111/j.1432-1033.1982.tb06731.x
Reference
2  [PMID:15101981]
  Authors
Aoshima M, Ishii M, Igarashi Y.
  Title
A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol Microbiol 52:751-61 (2004)
DOI:10.1111/j.1365-2958.2004.04009.x
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.18
IUBMB Enzyme Nomenclature: 6.2.1.18
ExPASy - ENZYME nomenclature database: 6.2.1.18
BRENDA, the Enzyme Database: 6.2.1.18
CAS: 856428-87-0

KEGG   REACTION: R01322Help
Entry
R01322                      Reaction                               

Name
Citrate:CoA ligase (ADP-forming)
Definition
ATP + Citrate + CoA <=> ADP + Orthophosphate + (3S)-Citryl-CoA
Equation
Comment
a part of multi-step reaction (see R00352, R01322+R00354)
Reaction class
RC00002  C00002_C00008
RC00004  C00010_C00566
RC00014  C00158_C00566
Enzyme
Pathway
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Orthology
K15232  citryl-CoA synthetase large subunit [EC:6.2.1.18]
K15233  citryl-CoA synthetase small subunit
Other DBs
RHEA: 21475

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