KEGG ORTHOLOGY: K15314

ORTHOLOGY: K15314

Entry

K15314 KO

Name

sgcE, mdpE, ncsE, kedE, calE8, pksE

Definition

enediyne polyketide synthase

Pathway

ko01059

Biosynthesis of enediyne antibiotics

ko01100

Metabolic pathways

ko01130

Biosynthesis of antibiotics

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

M00825

10-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 10-membered enediyne core

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K15314  sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15314  sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
  Iterative type I PKS
   Bacterial type
    K15314  sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase

Other DBs

RN:

R11435

COG:	COG0331 COG3321 COG1028

Genes

MAH:	MEALZ_1605

MBUR:

EQU24_12390

TIG:

THII_0012

POX:	MB84_31255

HOH:

Hoch_0693

LFB:	C1X05_03380

NBR:	O3I_023120

NTP:	CRH09_15810

NOZ:	DMB37_04400 DMB37_37225

REY:

O5Y_01845

REB:	XU06_02050

RQI:	C1M55_02140

SGR:	SGR_609(pksE)

SGB:

WQO_33990

STRM:

M444_38005

SCLF:

BB341_30230

SGS:	AVL59_07295 AVL59_19230

SPLU:

LK06_002505

RIA:	C7V51_07090 C7V51_07095

NGV:	CDO52_11635

ACTW:

SRO:

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30260

AMYC:

CU254_17290

AMYB:

BKN51_01415

AAB:	A4R43_37300

AMI:

Amir_4083

APRE:

CNX65_20450

SESP:

BN6_39290(pks6-2)

KPHY:

AOZ06_31050

LED:	BBK82_30820 BBK82_30825

ACTI:

UA75_19075

ACAD:

UA74_18585

AHG:	AHOG_16585(ppsA)

ALO:

CRK57498

STP:	Strop_0598 Strop_2697

SAQ:	Sare_0551 Sare_2179

MAU:	Micau_2514

MIL:

ML5_5849

MICB:

MicB006_4939

MICH:

FJK98_15650

VMA:	VAB18032_18450

ACTN:

L083_3210(pks1C)

PLAB:

PLAT:

CAI:

CHON:

MAR:

MPK:

MIQ:	B5D77_13875

MVZ:	myaer102_46860

CYJ:	Cyan7822_0309

NOP:	Nos7524_5243

NCN:	BZZ01_17185

HAU:

Haur_0866

AG:	AAM78012(ncsE) AAM94794(calE8) AAQ17110(mdpE) AFV52145(kedE)

» show all

Reference

PMID:20534556

Authors

Horsman GP, Chen Y, Thorson JS, Shen B

Title

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.

Journal

Proc Natl Acad Sci U S A 107:11331-5 (2010)
DOI:10.1073/pnas.1003442107

Reference

PMID:19362637

Authors

Horsman GP, Van Lanen SG, Shen B

Title

Iterative type I polyketide synthases for enediyne core biosynthesis.

Journal

Methods Enzymol 459:97-112 (2009)
DOI:10.1016/S0076-6879(09)04605-9

Reference

PMID:12183628 (sgcE)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_33990]

Reference

PMID:17918933 (mdpE)

Authors

Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B

Title

Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.

Journal

J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o

Sequence

[ag:AAQ17110]

Reference

PMID:15797213 (ncsE)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78012]

Reference

PMID:23360970 (kedE)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52145]

Reference

PMID:12183629 (calE8)

Authors

Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS

Title

The calicheamicin gene cluster and its iterative type I enediyne PKS.

Journal

Science 297:1173-6 (2002)
DOI:10.1126/science.1072105

Sequence

[ag:AAM94794]

All links

Ontology (5)   
   KEGG BRITE (2)   
   COG (3)   
Pathway (8)   
   KEGG PATHWAY (6)   
   KEGG MODULE (2)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (125)   
   KEGG GENES (70)   
   KEGG MGENES (24)   
   RefGene (28)   
   OC (3)   
Protein sequence (57)   
   UniProt (57)   
Literature (7)   
   PubMed (7)   
All databases (203)   

Download RDF

REACTION: R11435

Entry

R11435 Reaction

Definition

8 Malonyl-CoA + 7 NADPH + 7 H+ + Acyl-carrier protein <=> 3-Hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-[acp] + 8 CoA + 8 CO2 + 6 H2O + 7 NADP+

Equation

8 C00083 + 7 C00005 + 7 C00080 + C00229 <=> C21357 + 8 C00010 + 8 C00011 + 6 C00001 + 7 C00006

Pathway

rn01059

Biosynthesis of enediyne antibiotics

rn01100

Metabolic pathways

rn01130

Biosynthesis of antibiotics

Orthology

K15314

enediyne polyketide synthase

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Gene (71)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (70)   
All databases (87)   

Download RDF

DBGET integrated database retrieval system