Entry |
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Name |
sgcE, mdpE, ncsE, kedE, calE8, pksE
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Definition |
enediyne polyketide synthase
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Pathway |
ko01059 | Biosynthesis of enediyne antibiotics |
ko01130 | Biosynthesis of antibiotics |
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Module |
M00824 | 9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core |
M00825 | 10-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 10-membered enediyne core |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01059 Biosynthesis of enediyne antibiotics
K15314 sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K15314 sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
Iterative type I PKS
Bacterial type
K15314 sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase
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Other DBs |
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Genes |
» show all
   |
Reference |
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Authors |
Horsman GP, Chen Y, Thorson JS, Shen B |
Title |
Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes. |
Journal |
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Reference |
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Authors |
Horsman GP, Van Lanen SG, Shen B |
Title |
Iterative type I polyketide synthases for enediyne core biosynthesis. |
Journal |
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Reference |
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Authors |
Liu W, Christenson SD, Standage S, Shen B |
Title |
Biosynthesis of the enediyne antitumor antibiotic C-1027. |
Journal |
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Sequence |
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Reference |
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Authors |
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B |
Title |
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. |
Journal |
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Sequence |
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Reference |
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Authors |
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B |
Title |
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. |
Journal |
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Sequence |
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Reference |
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Authors |
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B |
Title |
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. |
Journal |
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Sequence |
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Reference |
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Authors |
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS |
Title |
The calicheamicin gene cluster and its iterative type I enediyne PKS. |
Journal |
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Sequence |
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