Entry |
|
Name |
noranthrone synthase;
polyketide synthase A (ambiguous);
PksA (ambiguous);
norsolorinic acid anthrone synthase
|
Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
Sysname |
malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming)
|
Reaction(IUBMB) |
7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O [RN: R10239]
|
Reaction(KEGG) |
|
Substrate |
malonyl-CoA [CPD: C00083];
hexanoyl-[acyl-carrier protein] [CPD: C05749]
|
Product |
|
Comment |
A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [1].
|
History |
EC 2.3.1.221 created 2013
|
Pathway |
ec01130 | Biosynthesis of antibiotics |
|
Orthology |
|
Genes |
 |
Reference |
|
Authors |
Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA |
Title |
Deconstruction of iterative multidomain polyketide synthase function. |
Journal |
|
Reference |
|
Authors |
Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA |
Title |
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. |
Journal |
|
Reference |
|
Authors |
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC |
Title |
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. |
Journal |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.221 |
|