KEGG   ORTHOLOGY: K15756Help
Entry
K15756                      KO                                     

Name
carC
Definition
2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase [EC:3.7.1.13]
Pathway
ko00621  Dioxin degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00544  Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00621 Dioxin degradation
    K15756  carC; 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.13  2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
     K15756  carC; 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase
BRITE hierarchy
Other DBs
RN: R05365
GO: 0018768
Genes
PSD: DSC_14565
PRE: PCA10_p0310(carC)
TTU: TERTU_1260
CYQ: Q91_0965
CZA: CYCME_1631 CYCME_1639
CYY: CPC19_07905
GBI: PG2T_01235
RBU: PG1C_11590
SSAN: NX02_18960
ERK: CD351_08230
BTS: Btus_2320
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gai Z, Wang X, Liu X, Tai C, Tang H, He X, Wu G, Deng Z, Xu P
  Title
The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5.
  Journal
PLoS One 5:e10018 (2010)
DOI:10.1371/journal.pone.0010018

KEGG   ENZYME: 3.7.1.13Help
Entry
EC 3.7.1.13                 Enzyme                                 

Name
2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase;
CarC
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase
Reaction(IUBMB)
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = anthranilate + (2E)-2-hydroxypenta-2,4-dienoate
Reaction(KEGG)
(other) R05365
Show
Substrate
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate;
H2O [CPD:C00001]
Product
anthranilate [CPD:C00108];
(2E)-2-hydroxypenta-2,4-dienoate
Comment
This enzyme catalyses the third step in the aerobic degradation pathway of carbazole. The effect of the presence of an amino group or hydroxyl group at the 2-position of the substrate is small. The enzyme has no cofactor requirement [2].
History
EC 3.7.1.13 created 2010
Pathway
ec00621  Dioxin degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15756  2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase
Genes
PSD: DSC_14565
PRE: PCA10_p0310(carC)
TTU: TERTU_1260
CYQ: Q91_0965
CZA: CYCME_1631 CYCME_1639
CYY: CPC19_07905
GBI: PG2T_01235
RBU: PG1C_11590
SSAN: NX02_18960
ERK: CD351_08230
BTS: Btus_2320
 » show all
Taxonomy
Reference
1  [PMID:12619671]
  Authors
Nojiri H, Taira H, Iwata K, Morii K, Nam JW, Yoshida T, Habe H, Nakamura S, Shimizu K, Yamane H, Omori T
  Title
Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10.
  Journal
Biosci Biotechnol Biochem 67:36-45 (2003)
DOI:10.1271/bbb.67.36
  Sequence
Reference
2  [PMID:12651123]
  Authors
Riddle RR, Gibbs PR, Willson RC, Benedik MJ
  Title
Purification and properties of 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole.
  Journal
Protein Expr Purif 28:182-9 (2003)
DOI:10.1016/S1046-5928(02)00676-9
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.13
IUBMB Enzyme Nomenclature: 3.7.1.13
ExPASy - ENZYME nomenclature database: 3.7.1.13
BRENDA, the Enzyme Database: 3.7.1.13

KEGG   REACTION: R05365Help
Entry
R05365                      Reaction                               

Name
2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate benzoylhydrolase
Definition
2-Hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O <=> 2-Hydroxy-2,4-pentadienoate + Anthranilate
Equation
Reaction class
RC00753  C00596_C08062
RC00757  C00108_C08062
Enzyme
Pathway
rn00621  Dioxin degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00544  Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate
Orthology
K15756  2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase [EC:3.7.1.13]
Other DBs
RHEA: 27873

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