KEGG   ORTHOLOGY: K15849
Entry
K15849                      KO                                     

Name
PAT, AAT
Definition
bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
Pathway
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
ko00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01230  Biosynthesis of amino acids
Module
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00360 Phenylalanine metabolism
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.1  aspartate transaminase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
    2.6.1.78  aspartate---prephenate aminotransferase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
    2.6.1.79  glutamate---prephenate aminotransferase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Other DBs
RN: R00694 R00734 R01731 R07276
GO: 0004069 0033853 0033854
Genes
ATH: AT2G22250(AAT)
ALY: 9316505
CRB: 17887943
CSAT: 104713666 104751865 109124540
EUS: EUTSA_v10000093mg
BRP: 103837904 103864337
BNA: 106368705 106375928 106411660 106446400
BOE: 106311364 106337354
RSZ: 108808584 108811314 108848628
THJ: 104824869
CPAP: 110819109
CIT: 102629885
TCC: 18611614
CAM: 101498423
LJA: Lj4g3v2819890.1(Lj4g3v2819890.1) Lj6g3v0527170.1(Lj6g3v0527170.1)
FVE: 101298618
RCN: 112186138
PPER: 18772763
PMUM: 103332445
PAVI: 110745611
ZJU: 107425444
CSV: 101212914
CMO: 103494808
MCHA: 111008458
CMAX: 111480013
CMOS: 111447760
CPEP: 111809015
RCU: 8265602
JCU: 105650883
MESC: 110628459
SLY: 100736464(PAT)
SPEN: 107018133
SOT: 102601259
CANN: 107851006
NSY: 104225971
NTO: 104111606
NAU: 109237300
SIND: 105171137
CCAV: 112515145
DCR: 108204769
OSA: 4324941
DOSA: Os01t0871300-01(Os01g0871300)
OBR: 102703547
ATS: 109754578(LOC109754578)
ZMA: 100274472(pco075539) 100276531
SITA: 101768098
MUS: 103986371
DCT: 110116229
PEQ: 110020052
ATR: 18422116
PPP: 112280653
APRO: F751_2191
MIS: MICPUN_59090(ASP2)
MPP: MICPUCDRAFT_71025(ASP2)
SPAR: SPRG_20135
 » show all
Reference
  Authors
Graindorge M, Giustini C, Jacomin AC, Kraut A, Curien G, Matringe M
  Title
Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: the last homeless enzyme of aromatic amino acids biosynthesis.
  Journal
FEBS Lett 584:4357-60 (2010)
DOI:10.1016/j.febslet.2010.09.037
  Sequence
[ath:AT2G22250]

KEGG   ENZYME: 2.6.1.79
Entry
EC 2.6.1.79                 Enzyme                                 

Name
glutamate---prephenate aminotransferase;
prephenate transaminase (ambiguous);
PAT (ambiguous);
L-glutamate:prephenate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-arogenate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate [RN:R07276]
Reaction(KEGG)
R07276
Substrate
L-arogenate [CPD:C00826];
2-oxoglutarate [CPD:C00026]
Product
prephenate [CPD:C00254];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate---prephenate aminotransferase). The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate [1].
History
EC 2.6.1.79 created 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
Orthology
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Genes
ATH: AT2G22250(AAT)
ALY: 9316505
CRB: 17887943
CSAT: 104713666 104751865 109124540
EUS: EUTSA_v10000093mg
BRP: 103837904 103864337
BNA: 106368705 106375928 106411660 106446400
BOE: 106311364 106337354
RSZ: 108808584 108811314 108848628
THJ: 104824869
CPAP: 110819109
CIT: 102629885
TCC: 18611614
CAM: 101498423
LJA: Lj4g3v2819890.1(Lj4g3v2819890.1) Lj6g3v0527170.1(Lj6g3v0527170.1)
FVE: 101298618
RCN: 112186138
PPER: 18772763
PMUM: 103332445
PAVI: 110745611
ZJU: 107425444
CSV: 101212914
CMO: 103494808
MCHA: 111008458
CMAX: 111480013
CMOS: 111447760
CPEP: 111809015
RCU: 8265602
JCU: 105650883
MESC: 110628459
SLY: 100736464(PAT)
SPEN: 107018133
SOT: 102601259
CANN: 107851006
NSY: 104225971
NTO: 104111606
NAU: 109237300
SIND: 105171137
CCAV: 112515145
DCR: 108204769
OSA: 4324941
DOSA: Os01t0871300-01(Os01g0871300)
OBR: 102703547
ATS: 109754578(LOC109754578)
ZMA: 100274472(pco075539) 100276531
SITA: 101768098
MUS: 103986371
DCT: 110116229
PEQ: 110020052
ATR: 18422116
PPP: 112280653
APRO: F751_2191
MIS: MICPUN_59090(ASP2)
MPP: MICPUCDRAFT_71025(ASP2)
SPAR: SPRG_20135
 » show all
Reference
1  [PMID:3985619]
  Authors
Bonner CA, Jensen RA.
  Title
Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris.
  Journal
Arch Biochem Biophys 238:237-46 (1985)
DOI:10.1016/0003-9861(85)90161-4
Reference
2  [PMID:2939644]
  Authors
Siehl DL, Connelly JA, Conn EE.
  Title
Tyrosine biosynthesis in Sorghum bicolor: characteristics of prephenate aminotransferase.
  Journal
Z Naturforsch [C] 41:79-86 (1986)
DOI:10.1515/znc-1986-1-213
Reference
3  [PMID:3298985]
  Authors
Bonner C, Jensen R.
  Title
Prephenate aminotransferase.
  Journal
Methods Enzymol 142:479-87 (1987)
DOI:10.1016/s0076-6879(87)42059-4
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.79
IUBMB Enzyme Nomenclature: 2.6.1.79
ExPASy - ENZYME nomenclature database: 2.6.1.79
BRENDA, the Enzyme Database: 2.6.1.79

KEGG   REACTION: R07276
Entry
R07276                      Reaction                               

Name
L-arogenate:2-oxoglutarate aminotransferase
Definition
L-Arogenate + 2-Oxoglutarate <=> Prephenate + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026  C00254_C00826
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01230  Biosynthesis of amino acids
Module
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
Orthology
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
Other DBs
RHEA: 22883

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