KEGG   ORTHOLOGY: K15941Help
Entry
K15941                      KO                                     

Name
snoaB, dnrG, aknX
Definition
deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.22  deoxynogalonate monooxygenase
     K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
    1.13.12.-  
     K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
BRITE hierarchy
Other DBs
RN: R06679 R09327
Genes
MAU: Micau_3995
MIL: ML5_4426
AG: AAA65205(dnrG) AAF70105(aknX) CAA12015(snoaB)
TaxonomyKoalaUniProt
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
  Authors
Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G
  Title
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
  Journal
Biochemistry 49:934-44 (2010)
DOI:10.1021/bi901985b
Reference
  Authors
Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y
  Title
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.
  Journal
J Bacteriol 184:6115-22 (2002)
DOI:10.1128/JB.184.22.6115-6122.2002
  Sequence

KEGG   REACTION: R06679Help
Entry
R06679                      Reaction                               

Name
12-deoxyaklanonic-acid:oxygen oxidoreductase
Definition
12-Deoxyaklanonic acid + Oxygen <=> Aklanonate + H2O
Equation
Comment
monooxygenase, aknX, dnr/dauG
Reaction class
RC01658  C12420_C12421
Enzyme
1.13.12.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Orthology
K15941  deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]

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