KEGG   ORTHOLOGY: K15942Help
Entry
K15942                      KO                                     

Name
snoaC, dnrC, dauC, aknG
Definition
O-methyltransferase / aklanonic acid methyltransferase [EC:2.1.1.- 2.1.1.288]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15942  snoaC, dnrC, dauC, aknG; O-methyltransferase / aklanonic acid methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.288  aklanonic acid methyltransferase
     K15942  snoaC, dnrC, dauC, aknG; O-methyltransferase / aklanonic acid methyltransferase
    2.1.1.-  
     K15942  snoaC, dnrC, dauC, aknG; O-methyltransferase / aklanonic acid methyltransferase
BRITE hierarchy
Other DBs
RN: R06675 R06680
Genes
MAU: Micau_3998
MIL: ML5_4423
AG: AAA65210(dnrC) AAB16936(dauC) AAF70111(aknG) CAA12014(snoaC)
TaxonomyKoalaUniProt
Reference
PMID:7836284
  Authors
Dickens ML, Ye J, Strohl WR
  Title
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
  Journal
J Bacteriol 177:536-43 (1995)
DOI:10.1128/JB.177.3.536-543.1995
  Sequence
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence

KEGG   ENZYME: 2.1.1.288Help
Entry
EC 2.1.1.288                Enzyme                                 

Name
aklanonic acid methyltransferase;
DauC;
AAMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:aklanonate O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate [RN:R06680]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
aklanonate [CPD:C12421]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methyl aklanonate [CPD:C12422]
Comment
The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
History
EC 2.1.1.288 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K15942  O-methyltransferase / aklanonic acid methyltransferase
Genes
MAU: Micau_3998
MIL: ML5_4423
Taxonomy
Reference
1  [PMID:7836284]
  Authors
Dickens ML, Ye J, Strohl WR.
  Title
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
  Journal
J Bacteriol 177:536-43 (1995)
DOI:10.1128/JB.177.3.536-543.1995
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.288
IUBMB Enzyme Nomenclature: 2.1.1.288
ExPASy - ENZYME nomenclature database: 2.1.1.288
BRENDA, the Enzyme Database: 2.1.1.288

KEGG   REACTION: R06680Help
Entry
R06680                      Reaction                               

Name
S-adenosyl-L-methionine:aklanonate O-methyltransferase
Definition
Aklanonate + S-Adenosyl-L-methionine <=> Methyl aklanonate + S-Adenosyl-L-homocysteine
Equation
Reaction class
RC00003  C00019_C00021
RC00460  C12421_C12422
Enzyme
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Orthology
K15942  O-methyltransferase / aklanonic acid methyltransferase [EC:2.1.1.- 2.1.1.288]
Other DBs
RHEA: 37878

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