| Entry |
|
|---|
| Name |
aklanonic acid methyl ester cyclase;
dauD (gene name);
aknH (gene name);
dnrD (gene name);
methyl aklanonate cyclase;
methyl aklanonate-aklaviketone isomerase (cyclizing);
aklaviketone lyase (decyclizing)
|
|---|
| Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
 |
|---|
| Sysname |
aklaviketone lyase (ring-opening)
|
|---|
| Reaction(IUBMB) |
aklaviketone = methyl aklanonate [RN: R06681]
|
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| Reaction(KEGG) |
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| Substrate |
|
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| Product |
methyl aklanonate [CPD: C12422]
|
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| Comment |
The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
|
|---|
| History |
EC 5.5.1.23 created 2013, modified 2014
|
|---|
| Pathway |
| ec01057 | Biosynthesis of type II polyketide products |
| ec01130 | Biosynthesis of antibiotics |
|
|---|
| Orthology |
| K15943 | nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase |
|
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| Genes |
 |
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| Reference |
|
|---|
| Authors |
Dickens ML, Ye J, Strohl WR. |
|---|
| Title |
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5. |
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| Journal |
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| Sequence |
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| Reference |
|
|---|
| Authors |
Kendrew SG, Katayama K, Deutsch E, Madduri K, Hutchinson CR |
|---|
| Title |
DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme. |
|---|
| Journal |
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| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G. |
|---|
| Title |
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.5.1.23 |
| ExPASy - ENZYME nomenclature database: | 5.5.1.23 |
|
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