KEGG   ORTHOLOGY: K15944Help
Entry
K15944                      KO                                     

Name
snoaF, dnrE, dauE, aknU
Definition
nogalaviketone/aklaviketone reductase [EC:1.1.1.- 1.1.1.362]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15944  snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.362  aklaviketone reductase
     K15944  snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase
    1.1.1.-  
     K15944  snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase
BRITE hierarchy
Other DBs
RN: R06677 R06682 R09329
Genes
MAU: Micau_4000
MIL: ML5_4421
AG: AAA65202(dnrE) AAB08021(dauE) AAF01806(snoaF) AAF73457(aknU)
TaxonomyKoalaUniProt
Reference
  Authors
Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K
  Title
The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.
  Journal
Mol Genet Genomics 266:276-88 (2001)
DOI:10.1007/s004380100554
  Sequence
Reference
PMID:8655529
  Authors
Dickens ML, Ye J, Strohl WR
  Title
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
  Journal
J Bacteriol 178:3384-8 (1996)
DOI:10.1128/JB.178.11.3384-3388.1996
  Sequence
Reference
  Authors
Raty K, Kunnari T, Hakala J, Mantsala P, Ylihonko K
  Title
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.
  Journal
Mol Gen Genet 264:164-72 (2000)
DOI:10.1007/s004380000306
  Sequence

KEGG   REACTION: R09329Help
Entry
R09329                      Reaction                               

Name
nogalavinone:NADP+ 7-oxidoreductase
Definition
Nogalaviketone + NADPH + H+ <=> Nogalavinone + NADP+
Equation
Comment
C7-ketoreductase, snoaF
Reaction class
RC00001  C00005_C00006
RC00234  C18630_C18631
Enzyme
1.1.1.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Orthology
K15944  nogalaviketone/aklaviketone reductase [EC:1.1.1.- 1.1.1.362]

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