| Entry |
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| Name |
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| Definition |
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| Pathway |
| ko01057 | Biosynthesis of type II polyketide products |
| ko01110 | Biosynthesis of secondary metabolites |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01057 Biosynthesis of type II polyketide products
K15955 doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K15955 doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.181 13-deoxydaunorubicin hydroxylase
K15955 doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, bacteria type
CYP129 family
K15955 doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
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| Other DBs |
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| Genes |
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| Reference |
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| Authors |
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A |
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| Title |
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. |
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| Journal |
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| Reference |
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| Authors |
Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR |
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| Title |
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Dickens ML, Priestley ND, Strohl WR |
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| Title |
In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA. |
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| Journal |
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| Sequence |
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