KEGG   ORTHOLOGY: K15955
Entry
K15955            Tight     KO                                     
Symbol
doxA, CYP129A
Name
13-deoxydaunorubicin hydroxylase [EC:1.14.13.181]
Pathway
map01057  Biosynthesis of type II polyketide products
map01110  Biosynthesis of secondary metabolites
Reaction
R06688  13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating)
R06689  13-dihydrodaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating)
R06690  daunorubicin,NADPH:oxygen oxidoreductase (hydroxylating)
R06691  13-deoxycarminomycin,NADPH:oxygen oxidoreductase (13-hydroxylating)
R06692  13-dihydrocarminomycin,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.181  13-deoxydaunorubicin hydroxylase
     K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP129 family
   K15955  doxA, CYP129A; 13-deoxydaunorubicin hydroxylase
Other DBs
COG: COG2124
Genes
SPEU: CGZ69_24370
AG: AAB08049(doxA) AAD04715(doxA)
Reference
PMID:17268612
  Authors
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A
  Title
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
  Journal
Nat Prod Rep 24:162-90 (2007)
DOI:10.1039/b507395m
Reference
PMID:9864344
  Authors
Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR
  Title
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.
  Journal
J Bacteriol 181:305-18 (1999)
DOI:10.1128/JB.181.1.305-318.1999
  Sequence
[ag:AAD04715]
Reference
PMID:9098063
  Authors
Dickens ML, Priestley ND, Strohl WR
  Title
In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.
  Journal
J Bacteriol 179:2641-50 (1997)
DOI:10.1128/JB.179.8.2641-2650.1997
  Sequence
[ag:AAB08049]

  All links  
Ontology (1)   
   COG (1)   
All databases (1)   

Download RDF
DBGET integrated database retrieval system