KEGG   ORTHOLOGY: K15956Help
Entry
K15956                      KO                                     

Name
dnrU
Definition
daunorubicin C-13 ketoreductase
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15956  dnrU; daunorubicin C-13 ketoreductase
BRITE hierarchy
Other DBs
RN: R06694
Genes
AG: AAD04717(dnrU)
TaxonomyKoalaUniProt
Reference
PMID:9864344
  Authors
Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR
  Title
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.
  Journal
J Bacteriol 181:305-18 (1999)
  Sequence

KEGG   REACTION: R06694Help
Entry
R06694                      Reaction                               

Definition
Daunorubicin <=> (13S)-13-Dihydrodaunorubicin
Equation
Comment
Daunorubicin C-13 ketoreductase, dnrU
Reaction class
RC00228  C01907_C12433
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01130  Biosynthesis of antibiotics
Orthology
K15956  daunorubicin C-13 ketoreductase

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