KEGG   ORTHOLOGY: K15957Help
Entry
K15957                      KO                                     

Name
rdmC
Definition
aclacinomycin methylesterase [EC:3.1.1.95]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15957  rdmC; aclacinomycin methylesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.95  aclacinomycin methylesterase
     K15957  rdmC; aclacinomycin methylesterase
BRITE hierarchy
Other DBs
RN: R09337 R10545
Genes
AG: AAA83422(rdmC)
TaxonomyKoalaUniProt
Reference
PMID:7751313
  Authors
Niemi J, Mantsala P
  Title
Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.
  Journal
J Bacteriol 177:2942-5 (1995)
DOI:10.1128/JB.177.10.2942-2945.1995
  Sequence

KEGG   ENZYME: 3.1.1.95Help
Entry
EC 3.1.1.95                 Enzyme                                 

Name
aclacinomycin methylesterase;
RdmC;
aclacinomycin methyl esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
aclacinomycin T acylhydrolase
Reaction(IUBMB)
aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol [RN:R10545]
Reaction(KEGG)
R10545;
(other) R09337
Show
Substrate
aclacinomycin T [CPD:C18634];
H2O [CPD:C00001]
Product
15-demethylaclacinomycin T [CPD:C20689];
methanol [CPD:C00132]
Comment
The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.
History
EC 3.1.1.95 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01130  Biosynthesis of antibiotics
Orthology
K15957  aclacinomycin methylesterase
Reference
1  [PMID:11004563]
  Authors
Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P
  Title
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
  Journal
Biochim Biophys Acta 1480:191-200 (2000)
DOI:10.1016/S0167-4838(00)00089-3
  Sequence
Reference
2  [PMID:12878604]
  Authors
Jansson A, Niemi J, Mantsala P, Schneider G
  Title
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
  Journal
J Biol Chem 278:39006-13 (2003)
DOI:10.1074/jbc.M304008200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.95
IUBMB Enzyme Nomenclature: 3.1.1.95
ExPASy - ENZYME nomenclature database: 3.1.1.95
BRENDA, the Enzyme Database: 3.1.1.95

KEGG   REACTION: R09337Help
Entry
R09337                      Reaction                               

Name
epsilon-rhodomycin-T acylhydrolase
Definition
epsilon-Rhodomycin T + H2O <=> 15-Demethoxy-epsilon-rhodomycin + Methanol
Equation
Reaction class
RC00460  C18640_C18641
RC00461  C00132_C18640
Enzyme
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01130  Biosynthesis of antibiotics
Orthology
K15957  aclacinomycin methylesterase [EC:3.1.1.95]

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