KEGG   ORTHOLOGY: K15960Help
Entry
K15960                      KO                                     

Name
mtmGIV
Definition
glycosyltransferase [EC:2.4.1.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15960  mtmGIV; glycosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-  
     K15960  mtmGIV; glycosyltransferase
BRITE hierarchy
Other DBs
RN: R06716 R06718
CAZy: GT1
Genes
AG: CAK50788(mtmGIV)
TaxonomyKoalaUniProt
Reference
  Authors
Blanco G, Fernandez E, Fernandez MJ, Brana AF, Weissbach U, Kunzel E, Rohr J, Mendez C, Salas JA
  Title
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.
  Journal
Mol Gen Genet 262:991-1000 (2000)
DOI:10.1007/PL00008667
  Sequence

KEGG   ORTHOLOGY: K15962Help
Entry
K15962                      KO                                     

Name
mtmC
Definition
D-mycarose 3-C-methyltransferase
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15962  mtmC; D-mycarose 3-C-methyltransferase
BRITE hierarchy
Other DBs
RN: R06718
Genes
AG: CAK50784(mtmC)
TaxonomyKoalaUniProt
Reference
  Authors
Gonzalez A, Remsing LL, Lombo F, Fernandez MJ, Prado L, Brana AF, Kunzel E, Rohr J, Mendez C, Salas JA
  Title
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.
  Journal
Mol Gen Genet 264:827-35 (2001)
DOI:10.1007/s004380000372
  Sequence

KEGG   REACTION: R06718Help
Entry
R06718                      Reaction                               

Definition
Premithramycin A2' + dTDP-D-mycarose <=> Premithramycin A3' + dTDP
Equation
Comment
glycosyltransferase, mtmGIV and D-mycarose 3-C-methyltransferase
Reaction class
RC00005  C00363_C12444
RC00049  C12385_C12386
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Orthology
K15960  glycosyltransferase [EC:2.4.1.-]
K15962  D-mycarose 3-C-methyltransferase

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