KEGG   ORTHOLOGY: K15966Help
Entry
K15966                      KO                                     

Name
mtmOIV
Definition
monooxygenase [EC:1.14.13.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15966  mtmOIV; monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     K15966  mtmOIV; monooxygenase
BRITE hierarchy
Other DBs
RN: R09353
Genes
AG: CAK50794(mtmOIV)
TaxonomyKoalaUniProt
Reference
  Authors
Gibson M, Nur-e-alam M, Lipata F, Oliveira MA, Rohr J
  Title
Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus.
  Journal
J Am Chem Soc 127:17594-5 (2005)
DOI:10.1021/ja055750t
Reference
  Authors
Rodriguez D, Quiros LM, Brana AF, Salas JA
  Title
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.
  Journal
J Bacteriol 185:3962-5 (2003)
DOI:10.1128/JB.185.13.3962-3965.2003
  Sequence

KEGG   REACTION: R09353Help
Entry
R09353                      Reaction                               

Name
premithramycin-B,NADPH:oxygen oxidoreductase
Definition
Premithramycin B + NADPH + H+ + Oxygen <=> Mithramycin DK + NADP+ + CO2
Equation
Comment
Baeyer-Villiger monooxygenase
Reaction class
RC00001  C00005_C00006
RC02490  C12388_C18711
Enzyme
1.14.13.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Orthology
K15966  monooxygenase [EC:1.14.13.-]

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