KEGG   ORTHOLOGY: K15968
Entry
K15968                      KO                                     

Name
tcmI
Definition
tetracenomycin F2 cyclase [EC:4.2.1.154]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15968  tcmI; tetracenomycin F2 cyclase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.154  tetracenomycin F2 cyclase
     K15968  tcmI; tetracenomycin F2 cyclase
Other DBs
RN: R06699
Genes
SGU: SGLAU_26345(tcmI)
STRC: AA958_32660
Reference
  Authors
Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I
  Title
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.
  Journal
J Biol Chem 279:37956-63 (2004)
DOI:10.1074/jbc.M406144200
Reference
PMID:8218177
  Authors
Shen B, Hutchinson CR
  Title
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:11149-54 (1993)
DOI:10.1021/bi00092a026
  Sequence
Reference
PMID:8244926
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
  Journal
J Bacteriol 175:7571-80 (1993)
DOI:10.1128/JB.175.23.7571-7580.1993

DBGET integrated database retrieval system