KEGG   ORTHOLOGY: K15968Help
Entry
K15968                      KO                                     

Name
tcmI
Definition
tetracenomycin F2 cyclase [EC:4.2.1.154]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15968  tcmI; tetracenomycin F2 cyclase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.154  tetracenomycin F2 cyclase
     K15968  tcmI; tetracenomycin F2 cyclase
BRITE hierarchy
Other DBs
RN: R06699
Genes
SGU: SGLAU_26345(tcmI)
STRC: AA958_32660
TaxonomyKoalaUniProt
Reference
  Authors
Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I
  Title
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.
  Journal
J Biol Chem 279:37956-63 (2004)
DOI:10.1074/jbc.M406144200
Reference
PMID:8218177
  Authors
Shen B, Hutchinson CR
  Title
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:11149-54 (1993)
DOI:10.1021/bi00092a026
  Sequence
Reference
PMID:8244926
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
  Journal
J Bacteriol 175:7571-80 (1993)
DOI:10.1128/JB.175.23.7571-7580.1993

KEGG   ENZYME: 4.2.1.154Help
Entry
EC 4.2.1.154                Enzyme                                 

Name
tetracenomycin F2 cyclase;
tcmI (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
tetracenomycin F2 hydro-lyase (tetracenomycin-F1-forming)
Reaction(IUBMB)
tetracenomycin F2 = tetracenomycin F1 + H2O [RN:R06699]
Reaction(KEGG)
Substrate
tetracenomycin F2 [CPD:C12366]
Product
tetracenomycin F1 [CPD:C12367];
H2O [CPD:C00001]
Comment
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
History
EC 4.2.1.154 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K15968  tetracenomycin F2 cyclase
Genes
SGU: SGLAU_26345(tcmI)
STRC: AA958_32660
Taxonomy
Reference
1  [PMID:8218177]
  Authors
Shen B, Hutchinson CR.
  Title
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis  of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:11149-54 (1993)
DOI:10.1021/bi00092a026
  Sequence
Reference
2  [PMID:15231835]
  Authors
Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I
  Title
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.
  Journal
J Biol Chem 279:37956-63 (2004)
DOI:10.1074/jbc.M406144200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.154
IUBMB Enzyme Nomenclature: 4.2.1.154
ExPASy - ENZYME nomenclature database: 4.2.1.154
BRENDA, the Enzyme Database: 4.2.1.154

KEGG   REACTION: R06699Help
Entry
R06699                      Reaction                               

Name
tetracenomycin-F2 hydro-lyase (tetracenomycin-F1-forming)
Definition
Tetracenomycin F2 <=> Tetracenomycin F1 + H2O
Equation
Reaction class
RC01656  C12366_C12367
Enzyme
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Orthology
K15968  tetracenomycin F2 cyclase [EC:4.2.1.154]
Other DBs
RHEA: 38854

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