KEGG   ORTHOLOGY: K15969Help
Entry
K15969                      KO                                     

Name
tcmH
Definition
tetracenomycin F1 monooxygenase [EC:1.13.12.21]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15969  tcmH; tetracenomycin F1 monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.21  tetracenomycin-F1 monooxygenase
     K15969  tcmH; tetracenomycin F1 monooxygenase
BRITE hierarchy
Other DBs
RN: R06700
Genes
SGU: SGLAU_26340(tcmH)
TaxonomyKoalaUniProt
Reference
PMID:8244926
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
  Journal
J Bacteriol 175:7571-80 (1993)
DOI:10.1128/JB.175.23.7571-7580.1993
  Sequence
Reference
PMID:8329392
  Authors
Shen B, Hutchinson CR
  Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:6656-63 (1993)
DOI:10.1021/bi00077a019

KEGG   ENZYME: 1.13.12.21Help
Entry
EC 1.13.12.21               Enzyme                                 

Name
tetracenomycin-F1 monooxygenase;
tcmH (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
tetracenomycin-F1:oxygen C5-monooxygenase
Reaction(IUBMB)
tetracenomycin F1 + O2 = tetracenomycin D3 + H2O [RN:R06700]
Reaction(KEGG)
Substrate
tetracenomycin F1 [CPD:C12367];
O2 [CPD:C00007]
Product
tetracenomycin D3 [CPD:C12368];
H2O [CPD:C00001]
Comment
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
History
EC 1.13.12.21 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K15969  tetracenomycin F1 monooxygenase
Genes
SGU: SGLAU_26340(tcmH)
Taxonomy
Reference
1  [PMID:8329392]
  Authors
Shen B, Hutchinson CR.
  Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:6656-63 (1993)
DOI:10.1021/bi00077a019
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.21
IUBMB Enzyme Nomenclature: 1.13.12.21
ExPASy - ENZYME nomenclature database: 1.13.12.21
BRENDA, the Enzyme Database: 1.13.12.21

KEGG   REACTION: R06700Help
Entry
R06700                      Reaction                               

Name
tetracenomycin-F1:oxygen C5-monooxygenase
Definition
Tetracenomycin F1 + Oxygen <=> Tetracenomycin D3 + H2O
Equation
Reaction class
RC01658  C12367_C12368
Enzyme
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Orthology
K15969  tetracenomycin F1 monooxygenase [EC:1.13.12.21]

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