KEGG   ORTHOLOGY: K15988
Entry
K15988            Tight     KO                                     
Symbol
tylG1
Name
tylactone synthase 1
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06448  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15988  tylG1; tylactone synthase 1
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15988  tylG1; tylactone synthase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15988  tylG1; tylactone synthase 1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Tylactone synthase
     K15988  tylG1; tylactone synthase 1
Genes
AG: AAB66504(tylG1)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:10322123
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence
[ag:AAB66504]

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (9)   
   KEGG REACTION (1)   
   KEGG RCLASS (8)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (23)   

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